15th International Workshop on Ataxia-Telangiectasia and ATM to be held in India

第十五届共济失调毛细血管扩张和 ATM 国际研讨会将在印度举行

基本信息

批准号：
8257390
负责人：
Tej K Pandita
金额：
$ 1万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-30 至 2013-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8257390
关键词：
Achievement Address Area Asians Ataxia Telangiectasia Australia Awareness Basic Science Breast Cell physiology Cerebellar Ataxia Chromatin Structure Clinical Clinical Treatment Clinical Trials Collaborations Complex Country DNA DNA Damage DNA Repair Development Diagnosis Disease Drug Delivery Systems Educational workshop Ensure Event Fostering Funding Applicant Future Genomic Instability Goals HIV Habitats Human Immune Immune system Immunity Immunologic Deficiency Syndromes Immunology Incidence Influenza Inherited Injury International Ionizing radiation Knowledge Left Letters Location Malignant Neoplasms Medical Molecular Mutation Nerve Degeneration Nervous system structure Pathology Pathway interactions Patients Pharmaceutical Preparations Phenotype Population Postdoctoral Fellow Proteins Radiation Tolerance Radiation therapy Reporting Research Research Personnel Research Training Role Scientist Signal Transduction Signaling Protein Site Stem cells Structure Students Suggestion Time Viral Virus Diseases Visit Work abstracting ataxia telangiectasia mutated protein base cancer risk cancer therapy career cost cost effectiveness interest malignant neurologic neoplasms meetings nervous system disorder neuropathology new therapeutic target peer planetary Atmosphere posters relating to nervous system response role model success symposium treatment trial web site

项目摘要

DESCRIPTION (provided by applicant): Funds are requested for partial support towards the 15th International Workshop on Ataxia- Telangiectasia and ATM, (ATW2012) which wil be held at the India Habitat Center, Delhi, India (http://www.indiahabitat.org/) on February 07-11, 2012. "As outgoing Chair (Richard Gatti), I am fulfilling my last duty, that of reporting on a recent tri to India to evaluate the feasibility and advisability of holding the next A-T Workshop (ATW2012) in New Delhi, India, under the direction of Tej Pandita. The official target date is February 7-11, 2012. During my short visit to Delhi, we looked at several very acceptable sites with which each of you would be quite pleased (Appendix 1)". We expect to have approximately 60 speakers; half being selected by the Organizing Committee, while the other half will come from abstracts submitted in response to an AT/ATM-focused list of topics posted on the conference website. The remaining abstracts will be presented as posters, 150 of which can be accommodated. Ataxia-telangiectasia (A-T) is a complex autosomal recessive disorder that is characterized by a progressive cerebellar ataxia, telangiectasia, immunodeficiency, genomic instability, ionizing radiation sensitivity, and a markedly increased incidence of cancer. In addition, ATM (ataxia-telangiectasia mutated) was recently shown to have a role in viral integration which may provide a new therapeutic target for controlling important viral infections, such as HIV and influenza. The objectives of the meeting to be held in India are to bring together basic and clinical researchers, especially younger investigators, working on various aspects of the clinical and cellular phenotypes of ATM/atm-deficient models, the role of ATM in neural differentiation and development, immunology and the ATM role in the DNA damage response. The local organizing committee constituted of eminent group of scientists with their office in Delhi will make all the necessary arrangements for the success of the proposed meeting (see letter of commitment: Appendix 2). By providing a comprehensive and stimulating atmosphere, the ATW2012 Workshop organizers will promote scientific interactions, discussions and cross-disciplinary research collaborations among scientists from different continents and increase awareness in the Asian continent about the ATM disease, treatment, possibilities for A-T patients and the cellular/molecular basis underlying ATM related pathologies. Specific areas of focus of the meeting will include the role of ATM in the nervous system, mechanisms of neurodegeneration, the role of DNA signaling proteins in neuropathology as well as breast and other human cancers, and the development of new drugs that could correct the effects of specific types of ATM mutations that cause A-T. This will be the first A-T Workshop that provides a forum to discuss the near term potential for applying the results from basic ATM studies to possible A-T clinical treatment trials and, in the future, other neurological diseases. PUBLIC HEALTH RELEVANCE: The goal of this international workshop is to bring together established and developing basic and clinical scientists from various countries together to participate in highly interactive scientific discourses through the presentation of their findings and dissemination of knowledge to generate awareness about the ATM related disorder in India, which represents a large population.

说明（由申请人提供）：请求资金部分支持第 15 届共济失调毛细血管扩张和 ATM 国际研讨会 (ATW2012)，该研讨会将在印度德里印度栖息地中心 (http://www.indiahabitat. org/），2012 年 2 月 7 日至 11 日。“作为即将离任的主席（理查德·加蒂），我正在履行我的最后一项职责，即报告最近的三前往印度，评估在 Tej Pandita 的指导下在印度新德里举办下一次 A-T 研讨会 (ATW2012) 的可行性和明智性。官方目标日期是 2012 年 2 月 7 日至 11 日。在我对德里的短暂访问期间，我们看了几个非常可接受的网站，你们每个人都会非常满意（附录 1）”。我们预计将有大约 60 名发言者；一半由组委会选择，另一半将来自针对会议网站上发布的以 AT/ATM 为重点的主题列表而提交的摘要。其余摘要将以海报形式呈现，可容纳 150 份。共济失调毛细血管扩张症（A-T）是一种复杂的常染色体隐性遗传疾病，其特征是进行性小脑共济失调、毛细血管扩张、免疫缺陷、基因组不稳定、电离辐射敏感性和癌症发病率显着增加。此外，ATM（共济失调毛细血管扩张突变）最近被证明在病毒整合中发挥作用，这可能为控制艾滋病毒和流感等重要病毒感染提供新的治疗靶点。将在印度举行的会议的目标是汇集基础和临床研究人员，特别是年轻的研究人员，研究 ATM/atm 缺陷模型的临床和细胞表型的各个方面、ATM 在神经分化和发育中的作用、免疫学和 ATM 在 DNA 损伤反应中的作用。当地组委会由杰出科学家组成，办事处设在德里，将为拟议会议的成功做出一切必要的安排（见承诺书：附录 2）。通过提供全面和刺激的氛围，ATW2012研讨会组织者将促进来自不同大陆的科学家之间的科学互动、讨论和跨学科研究合作，并提高亚洲大陆对ATM疾病、治疗、A-T患者的可能性和细胞的认识。 /ATM 相关病理学的分子基础。会议的具体重点领域将包括 ATM 在神经系统中的作用、神经变性机制、DNA 信号蛋白在神经病理学以及乳腺癌和其他人类癌症中的作用，以及可以纠正其影响的新药物的开发导致 A-T 的特定类型 ATM 突变。这将是第一个 A-T 研讨会，提供一个论坛来讨论将基本 ATM 研究结果应用于可能的 A-T 临床治疗试验以及未来其他神经系统疾病的近期潜力。公共健康相关性：本次国际研讨会的目标是将来自不同国家的成熟和发展中的基础和临床科学家聚集在一起，通过展示他们的发现和传播知识来参与高度互动的科学讨论，以提高对 ATM 相关疾病的认识在人口众多的印度。