15th International Workshop on Ataxia-Telangiectasia and ATM to be held in India

第十五届共济失调毛细血管扩张和 ATM 国际研讨会将在印度举行

• 批准号: 8257390
• 负责人: Tej K Pandita
• 金额: $ 1万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8257390
• 关键词: Achievement; Address; Area; Asians; Ataxia Telangiectasia; Australia; Awareness; Basic Science; Breast; Cell physiology; Cerebellar Ataxia; Chromatin Structure; Clinical; Clinical Treatment; Clinical Trials; Collaborations; Complex; Country; DNA; DNA Damage; DNA Repair; Development; Diagnosis; Disease; Drug Delivery Systems; Educational workshop; Ensure; Event; Fostering; Funding Applicant; Future; Genomic Instability; Goals; HIV; Habitats; Human; Immune; Immune system; Immunity; Immunologic Deficiency Syndromes; Immunology; Incidence; Influenza; Inherited; Injury; International; Ionizing radiation; Knowledge; Left; Letters; Location; Malignant Neoplasms; Medical; Molecular; Mutation; Nerve Degeneration; Nervous system structure; Pathology; Pathway interactions; Patients; Pharmaceutical Preparations; Phenotype; Population; Postdoctoral Fellow; Proteins; Radiation Tolerance; Radiation therapy; Reporting; Research; Research Personnel; Research Training; Role; Scientist; Signal Transduction; Signaling Protein; Site; Stem cells; Structure; Students; Suggestion; Time; Viral; Virus Diseases; Visit; Work; abstracting; ataxia telangiectasia mutated protein; base; cancer risk; cancer therapy; career; cost; cost effectiveness; interest; malignant neurologic neoplasms; meetings; nervous system disorder; neuropathology; new therapeutic target; peer; planetary Atmosphere; posters; relating to nervous system; response; role model; success; symposium; treatment trial; web site

DESCRIPTION (provided by applicant): Funds are requested for partial support towards the 15th International Workshop on Ataxia- Telangiectasia and ATM, (ATW2012) which wil be held at the India Habitat Center, Delhi, India (http://www.indiahabitat.org/) on February 07-11, 2012. "As outgoing Chair (Richard Gatti), I am fulfilling my last duty, that of reporting on a recent tri to India to evaluate the feasibility and advisability of holding the next A-T Workshop (ATW2012) in New Delhi, India, under the direction of Tej Pandita. The official target date is February 7-11, 2012. During my short visit to Delhi, we looked at several very acceptable sites with which each of you would be quite pleased (Appendix 1)". We expect to have approximately 60 speakers; half being selected by the Organizing Committee, while the other half will come from abstracts submitted in response to an AT/ATM-focused list of topics posted on the conference website. The remaining abstracts will be presented as posters, 150 of which can be accommodated. Ataxia-telangiectasia (A-T) is a complex autosomal recessive disorder that is characterized by a progressive cerebellar ataxia, telangiectasia, immunodeficiency, genomic instability, ionizing radiation sensitivity, and a markedly increased incidence of cancer. In addition, ATM (ataxia-telangiectasia mutated) was recently shown to have a role in viral integration which may provide a new therapeutic target for controlling important viral infections, such as HIV and influenza. The objectives of the meeting to be held in India are to bring together basic and clinical researchers, especially younger investigators, working on various aspects of the clinical and cellular phenotypes of ATM/atm-deficient models, the role of ATM in neural differentiation and development, immunology and the ATM role in the DNA damage response. The local organizing committee constituted of eminent group of scientists with their office in Delhi will make all the necessary arrangements for the success of the proposed meeting (see letter of commitment: Appendix 2). By providing a comprehensive and stimulating atmosphere, the ATW2012 Workshop organizers will promote scientific interactions, discussions and cross-disciplinary research collaborations among scientists from different continents and increase awareness in the Asian continent about the ATM disease, treatment, possibilities for A-T patients and the cellular/molecular basis underlying ATM related pathologies. Specific areas of focus of the meeting will include the role of ATM in the nervous system, mechanisms of neurodegeneration, the role of DNA signaling proteins in neuropathology as well as breast and other human cancers, and the development of new drugs that could correct the effects of specific types of ATM mutations that cause A-T. This will be the first A-T Workshop that provides a forum to discuss the near term potential for applying the results from basic ATM studies to possible A-T clinical treatment trials and, in the future, other neurological diseases. PUBLIC HEALTH RELEVANCE: The goal of this international workshop is to bring together established and developing basic and clinical scientists from various countries together to participate in highly interactive scientific discourses through the presentation of their findings and dissemination of knowledge to generate awareness about the ATM related disorder in India, which represents a large population.

描述（由申请人提供）：要求资金向第15个国际省telangiectasia和atm（ATW2012）进行部分支持，该研讨会将在印度德里的印度栖息地中心（http://wwwww.indiahabitat.org/）在印度德里的印度栖息地中心举行。在印度最近在印度举行的下一个A-T研讨会（ATW2012）的可行性和建议的报告，在Tej Pandita的指导下，官方目标日期是2012年2月7日至11日。我们希望有大约60位演讲者；一半是由组织委员会选出的，而另一半将来自响应于会议网站上发布的主题列表而提交的摘要。其余的摘要将作为海报，其中150个可以容纳。 共济失调 - 甲状腺激素（A-T）是一种复杂的常染色体隐性疾病，其特征是进行性小脑共济失调，teLangiectasia，免疫缺陷，基因组不稳定性，电离辐射敏感性以及明显增加的癌症发生率。此外，最近证明ATM（共济失调 - 胞毛突变）在病毒整合中起作用，这可能为控制重要的病毒感染（例如HIV和HIV和流感）提供了新的治疗靶标。 在印度举行的会议的目标是将基本和临床研究人员，尤其是年轻的研究人员汇总为ATM/ATM缺乏模型的临床和细胞表型的各个方面，ATM在神经分化和发育中的作用，免疫学，免疫学以及ATM在DNA损害响应中的作用。当地的组织委员会由著名的科学家小组及其在德里办公室组成，将为拟议会议的成功做出所有必要的安排（请参阅承诺信：附录2）。通过提供全面而刺激的氛围，ATW2012研讨会组织者将促进来自不同大陆的科学家之间的科学互动，讨论和跨学科研究合作，并提高亚洲大陆对ATM疾病，治疗，A-T患者的治疗可能性，A-T患者的可能性，细胞/分子基础ATM相关病理学的可能性。会议的特定重点领域将包括ATM在神经系统中的作用，神经退行性的机制，DNA信号蛋白在神经病理学以及乳腺癌和其他人类癌症中的作用以及可以纠正导致A-T的特定类型ATM突变的新药物的发展。这将是第一个提供一个论坛的A-T研讨会，讨论将基本ATM研究结果应用于可能的A-T临床治疗试验以及将来其他神经系统疾病的近期潜力。 公共卫生相关性：这项国际研讨会的目标是将来自各个国家的既定，基础和临床科学家聚集在一起，通过提出发现和知识传播来参与高度互动的科学论述，以引起对印度的ATM相关障碍的认识，这代表了大量人群。