CELLULAR HOMOLOGS IN A NEW SIMIAN HERPESVIRUS

新猿猴疱疹病毒的细胞同源物

• 批准号: 8172737
• 负责人: TIMOTHY M ROSE
• 金额: $ 31.02万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172737
• 关键词: AIDS related cancer; AIDS with Kaposi' s sarcoma; Africa South of the Sahara; Animal Model; Cercopithecine Herpesvirus 1; Computer Retrieval of Information on Scientific Projects Database; Development; Disease; Europe; Fibromatoses; Funding; Grant; HIV; Herpesviridae; Herpesviridae Infections; Homologous Gene; Human; Human Herpesvirus 8; Immune response; Immunosuppressive Agents; Infection; Institution; Kaposi Sarcoma; Macaca; Malignant Neoplasms; Pathogenesis; Play; Population Study; Research; Research Personnel; Resources; Retroperitoneal Space; Retroviridae; Role; SRV-2; Source; United States National Institutes of Health; Virus; transmission process; tumor initiation; tumorigenesis; AIDS related cancer; AIDS with Kaposi' s sarcoma; Africa South of the Sahara; Animal Model; Cercopithecine Herpesvirus 1; Computer Retrieval of Information on Scientific Projects Database; Development; Disease; Europe; Fibromatoses; Funding; Grant; HIV; Herpesviridae; Herpesviridae Infections; Homologous Gene; Human; Human Herpesvirus 8; Immune response; Immunosuppressive Agents; Infection; Institution; Kaposi Sarcoma; Macaca; Malignant Neoplasms; Pathogenesis; Play; Population Study; Research; Research Personnel; Resources; Retroperitoneal Space; Retroviridae; Role; SRV-2; Source; United States National Institutes of Health; Virus; transmission process; tumor initiation; tumorigenesis

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. AIDS-related Kaposi's sarcoma (KS) is the major AIDS-related malignancy. It is believed that an interaction between the retrovirus, HIV, and the herpesvirus, Kaposi's sarcoma-associated herpesvirus (KSHV), results in disease pathogenesis. KSHV-infection and KSHV-related malignancies are newly emerging diseases which are prevalent in the Mediterranean and Sub-Saharan Africa but are spreading into the U.S. and Europe. It is believed that SRV-2 related retroperitoneal fibromatosis (RF) which is associated with the KSHV-like herpesvirus, RFHVMn, is a unique animal model for understanding the interactions of retroviruses and herpesviruses in the induction of tumorigenesis. Understanding virus transmission and tumor initiation in this animal model would provide unique information concerning both the human and macaque diseases which is an essential prerequisite to developing treatments for KS. In this project, we propose to establish the baseline parameters of the infectious cycle of the macaque RFHV. To determine if this virus plays a role in the development of retroperitoneal fibromatosis (RF) we will characterize its infectious cycles and the perturbation of these cycles by SRV-2 and other immunosuppressive agents. We will study virus transmission and the host response to infection. Study populations will include macaques with either active, latent or experimental infections with RFHV.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 与艾滋病相关的卡波西肉瘤（KS）是与艾滋病有关的主要恶性肿瘤。 据认为，逆转录病毒，HIV和疱疹病毒（Kaposi）与肉瘤相关的疱疹病毒（KSHV）之间的相互作用导致疾病发病机理。 KSHV感染和与KSHV相关的恶性肿瘤是新兴的疾病，在地中海和撒哈拉以南非洲很普遍，但正在蔓延到美国和欧洲。 据认为，与KSHV样疱疹病毒RFHVMN相关的SRV-2相关腹膜后纤维瘤病（RF）是一种独特的动物模型，可用于了解肿瘤诱导中逆转录病毒和疱疹病毒的相互作用。 了解该动物模型中的病毒传播和肿瘤的启动将提供有关人和猕猴疾病的独特信息，这是开发KS治疗方法的必要先决条件。 在这个项目中，我们建议建立猕猴RFHV感染周期的基线参数。 为了确定该病毒在腹膜后纤维瘤病（RF）的发展中起作用，我们将表征其传染性周期以及SRV-2和其他免疫抑制剂对这些周期的扰动。 我们将研究病毒传播和宿主对感染的反应。 研究人群将包括带有RFHV活性，潜在或实验感染的猕猴。