RECOGNITION MEMORY: NEURAL CORRELATES OF ITEM MEMORY STRENGTH

识别记忆：项目记忆强度的神经关联

• 批准号: 8169875
• 负责人: Rosanna Kathleen Olsen
• 金额: $ 1.23万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169875
• 关键词: Behavioral; Computer Retrieval of Information on Scientific Projects Database; Fibrinogen; Functional Magnetic Resonance Imaging; Funding; Grant; Institution; Judgment; Measures; Memory; Performance; Research; Research Personnel; Resources; Retrieval; Shapes; Source; Stimulus; Testing; United States National Institutes of Health; base; memory recognition; relating to nervous system; research study; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Recognition memory decisions can be based on the perceived memory strength elicited by a test probe. One factor that is posited to influence memory strength is the degree of perceptual similarity between studied stimuli and test probes. Systematic manipulation of study-test perceptual similarity may provide leverage on the behavioral and neural bases of recognition decisions. In this experiment, we parametrically varied the degree of perceptual similarity between studied items and test probes to examine the impact of similarity on perceived memory strength and on the neural correlates of memory strength at retrieval. At study, shapes were encoded during performance of a size judgment task. At test, functional MRI (fMRI) measured neural responses as subjects made memory decisions about three types of test probes that varied in similarity to studied items: studied shapes, unstudied shapes that were morphs between a studied and an unstudied shape, and unstudied shapes. Subjects indicated whether they recognized the shape as old or new.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 识别记忆决策可以基于测试探针引发的感知记忆强度。影响记忆强度的因素之一是所研究的刺激和测试探针之间的感知相似程度。 对学习测试感知相似性的系统操作可以为识别决策的行为和神经基础提供杠杆作用。在这个实验中，我们参数化地改变了研究项目和测试探针之间的感知相似度，以检查相似性对感知记忆强度和检索时记忆强度的神经相关性的影响。在研究中，形状在执行尺寸判断任务时被编码。在测试中，功能性 MRI (fMRI) 测量了受试者对三种类型的测试探针做出记忆决定时的神经反应，这些测试探针与所研究的项目的相似性各不相同：研究的形状、未研究的形状（在研究的形状和未研究的形状之间变形）以及未研究的形状。受试者表明他们是否认为该形状是旧的还是新的。