INHIBITION OF ANTIBIOTIC-INDUCED MUTATION IN BACTERIA

抑制抗生素诱导的细菌突变

• 批准号: 8167586
• 负责人: SHELLEY LUSETTI
• 金额: $ 10.85万
• 依托单位: NEW MEXICO STATE UNIVERSITY LAS CRUCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167586
• 关键词: Antibiotic Resistance; Antibiotic-resistant organism; Antibiotics; Antimicrobial Resistance; Bacteria; Computer Retrieval of Information on Scientific Projects Database; DNA Repair; Drug Delivery Systems; Evolution; Explosion; Funding; Grant; Induced Mutation; Institution; Molecular Target; Mutation; Pathway interactions; Peptides; Pharmaceutical Preparations; Research; Research Personnel; Resistance; Resistance Process; Resources; Source; United States National Institutes of Health; antimicrobial drug; antimicrobial peptide; combat; global health; killings

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Bacterial resistance to antimicrobial drugs has the potential to become a global health crisis. This problem has necessitated an explosion of research to discover new drug targets as well as synthetic antibiotics. While this tactic is essential to stay ahead of the evolution of antibiotic resistant organisms, it is also important to combat the resistance process. Bacteria can acquire resistance to antibiotics through chromosomal mutations and high rates of resistance-conferring chromosomal mutations are at least partially due to pathways induced to repair damaged DNA caused either directly or indirectly by the antibiotic. Unlike other antimicrobial peptides currently being studied, we are looking for peptides that reduce the mutability of bacteria as opposed to killing the bacteria. Once identified, these peptides could potentially serve as antibiotic additives and could be used to reduce the evolution rate of bacteria regardless of the molecular target of the drug.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 细菌对抗菌药物的耐药性有可能成为全球健康危机。这个问题需要进行研究以发现新药物靶标和合成抗生素。尽管这种策略对于保持抗生素耐药生物的进化至关重要，但对抗抗药性过程也很重要。细菌可以通过染色体突变获得对抗生素的耐药性，高耐药性染色体突变的速率至少部分是由于诱导修复受抗生素直接或间接引起的受损DNA的途径。与目前正在研究的其他抗菌肽不同，我们正在寻找可降低细菌可突变性而不是杀死细菌的肽。一旦鉴定出，这些肽可能有可能用作抗生素添加剂，并且无论该药物的分子靶标如何，都可以用来降低细菌的进化率。