Tissue Acquisition, Sample Processing and Pathology

组织采集、样品处理和病理学

• 批准号: 8126197
• 负责人: RICHARD G CARROLL
• 金额: $ 13.64万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8126197
• 关键词: Anatomy; Archives; Cataloging; Catalogs; Clinical; Clinical Trials; Conflict (Psychology); Diagnosis; Enrollment; Goals; Human; Immune; Laboratories; Lentivirus Vector; Mediating; Mus; Operative Surgical Procedures; Pathologic; Pathologist; Pathology; Pathology processes; Patients; Plasmids; Process; Role; Sampling; Specimen; Time; Tissues; Transfection; Tumor Cell Line; Tumor-Derived; meetings; stable cell line; tumor; tumor xenograft

The goals of the Tissue Acquisition, Processing, and Pathology (TAPP) Core (formerly known as the Pathology Core) are to: 1. Review and analyze pathologic specimens from clinical trial patients. 2. Process and archive clinical specimens from the ongoing and planned clinical trials. 3. Tissue acquisition. 4. Establish stable cell lines from tumors derived from clinical trial subjects and other surgical patients. 5. Modify tumor cell lines through plasmid transfection and lentiviral vector-mediated transduction. 6. Establish and characterize human tumor xenografts in immune-deficient Mice. Dr. Richard Carroll will be the Director of the TAPP Core. Dr. Leslie Litzky, a Board-Certified Anatomic Pathologist, will continue in her previous role as the designated reference pathologist for confirmation of diagnosis prior to patient enrollment in clinical trials.

组织采集，加工和病理（TAPP）核心的目标（以前称为 病理核心）是： 1。审查和分析临床试验患者的病理标本。 2。来自正在进行的和计划的临床试验的过程和档案临床标本。 3。采集组织。 4。从临床试验受试者和其他手术的肿瘤中建立稳定的细胞系 患者。 5。通过质粒转染和慢病毒载体介导的转导修饰肿瘤细胞系。 6。在免疫缺陷型小鼠中建立并表征人类肿瘤异种移植物。 理查德·卡洛尔（Richard Carroll）博士将担任Tapp Core的主任。莱斯利·利兹基（Leslie Litzky）博士，董事会认证 解剖病理学家将继续担任她以前作为指定参考病理学家的角色 在临床试验中入学前确认诊断。