Optical detection of neural activity with phase sensitive interferometry
使用相敏干涉测量法光学检测神经活动
基本信息
- 批准号:7414027
- 负责人:
- 金额:$ 9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-05-01 至 2008-12-31
- 项目状态:已结题
- 来源:
- 关键词:Action PotentialsAddressAnimal ModelAnimalsArchitectureAwardBehaviorBiological Neural NetworksBrainChemicalsClinicalComplementComputer information processingDetectionDevelopmentDiseaseDyesElectrodesElectrophysiology (science)EvaluationEyeFiberFoundationsFundingFutureGlaucomaGoalsHistologyImageIn VitroIndividualInstructionInterferometryInvasiveLaboratoriesLateralLeadLightLimulus polyphemusMentorsMethodsNerveNeuronsNeurosciencesNeurosciences ResearchOptic NerveOptical Coherence TomographyOptical MethodsOpticsPatternPhasePhysicsPhysiologicalProcessRangeResearchResearch PersonnelResearch Project GrantsResearch ProposalsResolutionRetinaStructureSupervisionSwellingSystemTechniquesTechnologyTimeTissuesTrainingTranslatingUnited States National Institutes of HealthVisual system structureWorkXiphosurabasebioimagingcareerclinical applicationcompound eyeexperiencein vivoinsightmedical schoolsnanoscalenoveloptical imagingprogramsreceptorrelating to nervous systemresearch studysuccessvisual informationvoltage
项目摘要
DESCRIPTION (provided by applicant):
This K99/R00 proposal on the development of optical methods for imaging transient structural changes associated with neural activity integrates rigorous physics, biomedical, and neuroscience research, close career mentoring, and tailored coursework to establish Dr. B. Hyle Park as an independent investigator. Having completed his graduate research in physics, Dr. Park is now continuing his research at the Wellman Center for Photomedicine as a research fellow and is making the transition to research independence. He has focused on biomedical imaging, particularly in the development and clinical application of polarization- sensitive optical coherence tomography. Dr. Park now seeks to complement this grounding in biomedical optics with mentored research in the application of these optical techniques to neuroscience. His research proposal addresses the need for non-contact detection of neural structure and activity. Current techniques for detection of action potential propagation involve direct contact with electrodes or introduction of chemical markers, such as Ca++ dyes. In this K99/R00, he focuses on optical detection of transient structural changes that accompany spike propagation in neurons using phase-sensitive interferometry. Successful completion of the proposed research will enable optical detection of the structure and activity of nerves and neuronal ensembles in vitro, and lay the groundwork for in vivo application as well as providing the preliminary results necessary for a successful R01 application. This work not only has potential application as a complement to electrophysiology, but would be of use in clinically important regions, such as the retina, that are largely inaccessible with current techniques. Co-mentor Dr. Johannes F. de Boer has an established track record in the development of optical imaging methods and has successfully translated emerging research to ophthalmological and clinical use. Co-mentor Dr. Christopher L. Passaglia has experienced similar success in the study of how visual information is represented in the eye's input to the brain and how that changes as diseases, like glaucoma, inflict damage upon the retina. In addition to their supervision, Dr. Park will have access to coursework in neuroscience, and the ethical conduct of research at Harvard Medical School. The opportunities provided by this career award will allow Dr. Park to combine expertise in physics and biomedical optics with neuroscience, substantially adding to his capabilities as an independent researcher.
描述(由申请人提供):
这项 K99/R00 提案旨在开发用于对与神经活动相关的瞬态结构变化进行成像的光学方法,该提案整合了严谨的物理学、生物医学和神经科学研究、密切的职业指导和量身定制的课程,以使 B. Hyle Park 博士成为一名独立研究者。完成物理学研究生研究后,Park 博士现在作为研究员在威尔曼光医学中心继续他的研究,并正在向独立研究过渡。他专注于生物医学成像,特别是偏振敏感光学相干断层扫描的开发和临床应用。 Park 博士现在寻求通过将这些光学技术应用于神经科学的指导研究来补充生物医学光学的基础。他的研究提案解决了非接触式检测神经结构和活动的需求。目前检测动作电位传播的技术涉及直接接触电极或引入化学标记物,例如 Ca++ 染料。在这款 K99/R00 中,他专注于使用相敏干涉测量法对伴随神经元尖峰传播的瞬态结构变化进行光学检测。该研究的成功完成将能够在体外对神经和神经元群的结构和活动进行光学检测,为体内应用奠定基础,并为 R01 的成功应用提供必要的初步结果。这项工作不仅具有作为电生理学补充的潜在应用,而且可用于临床上重要的区域,例如视网膜,这些区域在目前的技术中基本上无法到达。联合导师 Johannes F. de Boer 博士在光学成像方法的开发方面拥有良好的记录,并成功地将新兴研究转化为眼科和临床应用。联合导师 Christopher L. Passaglia 博士在研究视觉信息如何在眼睛向大脑的输入中表示以及随着青光眼等疾病对视网膜造成损害时视觉信息如何变化的研究中也取得了类似的成功。除了他们的监督之外,帕克博士还将有机会学习哈佛医学院的神经科学课程以及研究的道德行为。该职业奖提供的机会将使 Park 博士能够将物理学和生物医学光学方面的专业知识与神经科学相结合,从而大大增强他作为独立研究员的能力。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
In vivo optical microscopy of peripheral nerve myelination with polarization sensitive-optical coherence tomography.
使用偏振敏感光学相干断层扫描对周围神经髓鞘形成进行体内光学显微镜观察。
- DOI:
- 发表时间:2015-04
- 期刊:
- 影响因子:3.5
- 作者:Henry, Francis P;Wang, Yan;Rodriguez, Carissa L R;Randolph, Mark A;Rust, Esther A Z;Winograd, Jonathan M;de Boer, Johannes F;Park, B Hyle
- 通讯作者:Park, B Hyle
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Boris Hyle Park其他文献
Boris Hyle Park的其他文献
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{{ truncateString('Boris Hyle Park', 18)}}的其他基金
Optical Detection of Neural Activity With Phase Sensitive Interferometry
使用相敏干涉测量法光学检测神经活动
- 批准号:
7714795 - 财政年份:2009
- 资助金额:
$ 9万 - 项目类别:
Optical Detection of Neural Activity With Phase Sensitive Interferometry
使用相敏干涉测量法光学检测神经活动
- 批准号:
7753212 - 财政年份:2009
- 资助金额:
$ 9万 - 项目类别:
Optical Detection of Neural Activity With Phase Sensitive Interferometry
使用相敏干涉测量法光学检测神经活动
- 批准号:
8015623 - 财政年份:2009
- 资助金额:
$ 9万 - 项目类别:
Optical detection of neural activity with phase sensitive interferometry
使用相敏干涉测量法光学检测神经活动
- 批准号:
7243818 - 财政年份:2007
- 资助金额:
$ 9万 - 项目类别:
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