Purchase of a Single Crystal Defractometer for Use with Small Crystals

购买用于小晶体的单晶折射仪

• 批准号: 8050267
• 负责人: DENNIS P CURRAN
• 金额: $ 41.81万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8050267
• 关键词: Aging; Biological; Biological Factors; Catalysis; Chemistry; Complement; Copper; Crystallography; Development; Funding; Libraries; Methodology; Methods; Minor; Oligosaccharides; Peptide Synthesis; Pharmaceutical Chemistry; Postdoctoral Fellow; Radiation; Request for Proposals; Research; Roentgen Rays; Sampling; Services; Source; Structure; Students; Time; Tube; United States National Institutes of Health; X ray diffraction analysis; X-Ray Diffraction; drug discovery; drug synthesis; experience; instrument; instrumentation; seal; sensor; small molecule; Aging; Biological; Biological Factors; Catalysis; Chemistry; Complement; Copper; Crystallography; Development; Funding; Libraries; Methodology; Methods; Minor; Oligosaccharides; Peptide Synthesis; Pharmaceutical Chemistry; Postdoctoral Fellow; Radiation; Request for Proposals; Research; Roentgen Rays; Sampling; Services; Source; Structure; Students; Time; Tube; United States National Institutes of Health; X ray diffraction analysis; X-Ray Diffraction; drug discovery; drug synthesis; experience; instrument; instrumentation; seal; sensor; small molecule

DESCRIPTION (provided by applicant): This is a research instrumentation proposal that requests funding for a Bruker X8 Prospector Ultra Single Crystal X-ray Diffractometer. The diffractometer will be integrated into the existing Chemistry Department Core X-ray Diffraction Facility, which is in turn is part of a larger Small Molecule Characterization Core. The instrument will be shared by a group of seven major users with NIH funding (Curran (PI), Brummond, Floreancig, Koide, Nelson, Wilcox, Wipf) and three minor users. It will be used primarily to solve the crystal structures of small and medium-sized organic molecules and biomolecules. The instrument will be operated by a full time Director of Crystallography with over two decades of experience, and will provide services to about 80 students and postdoctoral fellows on NIH-supported projects. The new diffractometer with a modern copper X-ray source will complement an aging but still useful diffractometer with conventional sealed tube Mo K? radiation. The new diffractometer will expedite the research of these groups by providing structures from smaller crystals (a critical current need), by providing rapid turn around time on synthetic intermediates, and by solving absolute configurations of samples without heavy atoms. This is a crucial support instrument for research in medicinal chemistry, diversity-oriented synthesis, library synthesis, synthetic methodology, catalysis development, sensor synthesis, natural products synthesis, and synthesis of peptides and oligosaccharides. Biomedical themes are replete and include drug discovery, biological probe discovery, new methods for drug synthesis, analysis of biological milieu, and understanding and imitation of important biomolecules. PUBLIC HEALTH RELEVANCE: This is a research instrumentation proposal that requests funding for a Bruker X8 Prospector Ultra Single Crystal X-ray Diffractometer. The instrument will be shared by a group of seven major users (all NIH funded) and three minor users primarily to solve the crystal structures of small and medium-sized organic molecules. This is a crucial support instrument for research in medicinal chemistry, diversity-oriented synthesis, library synthesis, synthetic methodology, sensor synthesis, natural products synthesis, and synthesis of peptides and oligosaccharides. Biomedical themes are replete and include drug discovery, biological probe discovery, new methods for drug synthesis, analysis of biological milieu, and understanding and imitation of important biomolecules.

描述（由申请人提供）：这是一项研究仪器提案，要求为Bruker X8勘探者超单晶X射线衍射仪提供资金。衍射仪将集成到现有的化学系核心X射线衍射设施中，这又是较大的小分子表征核心的一部分。该乐器将由NIH资金（Curran（Pi），Brummond，Floreancig，Koide，Koide，Koide，Nelson，Wilcox，WIPF）和三名未成年人的七个主要用户组成。它将主要用于解决中小型有机分子和生物分子的晶体结构。该乐器将由全职晶体学总监运营，并拥有超过二十年的经验，并将在NIH支持的项目中为大约80名学生和博士后研究员提供服务。具有现代铜X射线源的新衍射仪将与常规密封管Mo K相互补充，但仍然有用的衍射仪？辐射。新的衍射仪将通过提供较小的晶体（临界电流需求），通过在合成中间体上快速扭转时间以及解决没有沉重原子的样品的绝对构型来加快这些组的研究。这是用于研究药物化学，多样性合成，库合成，合成方法论，催化发育，传感器合成，天然产物合成以及肽和寡糖合成的关键支持工具。生物医学主题是充实的，包括药物发现，生物学探针发现，药物合成的新方法，生物环境分析以及对重要生物分子的理解和模仿。 公共卫生相关性：这是一项研究工具提案，要求为Bruker X8勘探者Ultra单晶X射线衍射仪提供资金。该仪器将由一组由七个主要用户（所有NIH资助）组成的组和三名未成年人使用，主要是为了解决中小型有机分子的晶体结构。这是用于研究药物化学，多样性合成，库合成，合成方法论，传感器合成，天然产物合成以及肽和寡糖合成的至关重要的支持工具。 生物医学主题是充实的，包括药物发现，生物学探针发现，药物合成的新方法，生物环境分析以及对重要生物分子的理解和模仿。