Internalizing pathways to drug use: A multi-sample analysis

药物使用的内化途径：多样本分析

基本信息

批准号：
8013536
负责人：
PATRICK J CURRAN
金额：
$ 35.57万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-08-15 至 2012-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8013536
关键词：
5 year old Adolescence Adolescent Adult Affect Age Alcohol or Other Drugs use Alcoholism Alcohols Anxiety Archives Behavioral Child Childhood Cognitive Comorbidity Data Data Set Deceleration Depressed mood Development Disease Drug usage Etiology Family Gender Goals Health behavior Interview Life Literature Longitudinal Studies Marijuana Mediating Mental Depression Methods Michigan Modeling Nursery Schools Outcome Parents Participant Pathway interactions Pattern Pharmaceutical Preparations Phenotype Population Prevention Prevention program Prevention strategy Process Research Personnel Risk Risk Factors Sampling Sampling Studies Self Medication Statistical Methods Subgroup Substance Use Disorder Surveys Symptoms Temperament Testing Time Tobacco Wood material Youth age difference aged anti social children of alcoholics cohort college contextual factors depressive symptoms design effective intervention effective therapy emerging adult experience high risk high school novel population based problem drinker public health relevance social stressor theories trait treatment program young adult

项目摘要

DESCRIPTION (provided by applicant): In this application, we evaluate an internalizing pathway to substance use disorders (SUDs) and consider the etiology of Negative Affect SUDs, a potential phenotype of SUDs identifiable by comorbidity with disorders involving negative affect (i.e., depression and anxiety). We conduct an integrative (secondary) analysis (refined in our prior project period) involving the simultaneous analysis of three nationally prominent longitudinal studies of children of alcoholic parents and matched controls that collectively span the first four decades of life (ages 2 through 38). Understanding developmental pathways leading to SUDs is critical in efforts to design and implement effective intervention and treatment programs for youth. Although behavioral indicators of risk for adolescent substance involvement appear as early as 2-5 years of age, few theories about developmental pathways to SUDs consider risk processes that begin in the preschool years. Moreover, few studies are capable of evaluating theories about these developmental pathways. Longitudinal studies that span the first four decades of life, when SUDs emerge, peak and begin to decline, are rare. Available cohort- or population-based studies often yield too few cases to disentangle different pathways for SUDs. Thus, long-term, longitudinal studies of high-risk populations, such as children of alcoholic parents, are invaluable for articulating developmental pathways to SUDs. Using this method, we pursue five specific aims: (1) to define and test an internalizing pathway to SUDs and to evaluate whether evidence supports heterotypic continuity (i.e., different developmental expressions of a single underlying trait) of Negative Affect SUDs over time, (2) to examine the developmentally-varying unique, mediated and interactive effects of internalizing and externalizing processes as predictors of substance involvement and Negative Affect SUDs across the first four decades of life, (3) to examine gender, parental depressive alcoholism, and contextual factors as important moderators of progression along an internalizing pathway toward Negative Affect SUDs as a function of developmental timing, (4) to examine whether the predictive utility of an internalizing model differs over various substances used in isolation (i.e., alcohol, tobacco, marijuana, stimulant and depressant drug) or in combination with one another, and (5) to develop methods for integrative analysis, to utilize these methods to test Aims 1-4, and to disseminate these methods to other applied researchers. PUBLIC HEALTH RELEVANCE: Our application tests an internalizing pathway to substance use disorder over the first four decades of life. Studies of such early emerging but persistent pathways are rare but critical to efforts to design and implement effective intervention and treatment programs for youth.

描述（由申请人提供）：在本申请中，我们评估了物质使用障碍（SUD）的内化途径，并考虑了负面影响 SUD 的病因学，这是一种 SUD 的潜在表型，可通过与涉及负面影响的疾病（即抑郁症和抑郁症）共存来识别。焦虑）。我们进行了一项综合（二级）分析（在我们之前的项目期间进行了完善），涉及对三项全国著名的纵向研究进行同步分析，这些研究涉及酗酒父母的孩子和匹配的对照，这些研究共同跨越了生命的前四十年（2至38岁）。了解导致 SUD 的发展途径对于为青少年设计和实施有效的干预和治疗计划至关重要。尽管青少年物质参与风险的行为指标早在 2-5 岁时就出现了，但很少有关于 SUD 发展途径的理论考虑从学龄前开始的风险过程。此外，很少有研究能够评估有关这些发展途径的理论。跨越生命前四十年（SUD 出现、达到顶峰并开始下降）的纵向研究很少。现有的基于队列或人群的研究通常产生的病例太少，无法理清 SUD 的不同途径。因此，对高风险人群（例如酗酒父母的孩子）进行长期纵向研究对于阐明 SUD 的发展途径非常有价值。使用这种方法，我们追求五个具体目标：（1）定义和测试 SUD 的内化途径，并评估证据是否支持随着时间的推移负面影响 SUD 的异型连续性（即单个潜在特征的不同发展表达），（ 2) 检查内化和外化过程的发展变化独特的、中介的和交互的影响，作为生命前四十年物质参与和负面影响 SUD 的预测因素，(3) 检查性别、父母抑郁性酗酒和背景因素是沿着内化途径向负面影响 SUD 发展的重要调节因素，作为发育时间的函数，（4）检查内化模型的预测效用是否与单独使用的各种物质不同（即酒精、烟草、大麻、兴奋剂和镇静剂）或相互结合，以及（5）开发综合分析方法，利用这些方法来测试目标1-4，并将这些方法传播给其他应用研究人员。公共健康相关性：我们的应用程序测试了生命前四十年物质使用障碍的内化途径。对这种早期出现但持续存在的途径的研究很少，但对于为青年设计和实施有效的干预和治疗计划至关重要。