Internalizing pathways to drug use: A multi-sample analysis

药物使用的内化途径：多样本分析

基本信息

批准号：
8013536
负责人：
PATRICK J CURRAN
金额：
$ 35.57万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-08-15 至 2012-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8013536
关键词：
5 year old Adolescence Adolescent Adult Affect Age Alcohol or Other Drugs use Alcoholism Alcohols Anxiety Archives Behavioral Child Childhood Cognitive Comorbidity Data Data Set Deceleration Depressed mood Development Disease Drug usage Etiology Family Gender Goals Health behavior Interview Life Literature Longitudinal Studies Marijuana Mediating Mental Depression Methods Michigan Modeling Nursery Schools Outcome Parents Participant Pathway interactions Pattern Pharmaceutical Preparations Phenotype Population Prevention Prevention program Prevention strategy Process Research Personnel Risk Risk Factors Sampling Sampling Studies Self Medication Statistical Methods Subgroup Substance Use Disorder Surveys Symptoms Temperament Testing Time Tobacco Wood material Youth age difference aged anti social children of alcoholics cohort college contextual factors depressive symptoms design effective intervention effective therapy emerging adult experience high risk high school novel population based problem drinker public health relevance social stressor theories trait treatment program young adult

项目摘要

DESCRIPTION (provided by applicant): In this application, we evaluate an internalizing pathway to substance use disorders (SUDs) and consider the etiology of Negative Affect SUDs, a potential phenotype of SUDs identifiable by comorbidity with disorders involving negative affect (i.e., depression and anxiety). We conduct an integrative (secondary) analysis (refined in our prior project period) involving the simultaneous analysis of three nationally prominent longitudinal studies of children of alcoholic parents and matched controls that collectively span the first four decades of life (ages 2 through 38). Understanding developmental pathways leading to SUDs is critical in efforts to design and implement effective intervention and treatment programs for youth. Although behavioral indicators of risk for adolescent substance involvement appear as early as 2-5 years of age, few theories about developmental pathways to SUDs consider risk processes that begin in the preschool years. Moreover, few studies are capable of evaluating theories about these developmental pathways. Longitudinal studies that span the first four decades of life, when SUDs emerge, peak and begin to decline, are rare. Available cohort- or population-based studies often yield too few cases to disentangle different pathways for SUDs. Thus, long-term, longitudinal studies of high-risk populations, such as children of alcoholic parents, are invaluable for articulating developmental pathways to SUDs. Using this method, we pursue five specific aims: (1) to define and test an internalizing pathway to SUDs and to evaluate whether evidence supports heterotypic continuity (i.e., different developmental expressions of a single underlying trait) of Negative Affect SUDs over time, (2) to examine the developmentally-varying unique, mediated and interactive effects of internalizing and externalizing processes as predictors of substance involvement and Negative Affect SUDs across the first four decades of life, (3) to examine gender, parental depressive alcoholism, and contextual factors as important moderators of progression along an internalizing pathway toward Negative Affect SUDs as a function of developmental timing, (4) to examine whether the predictive utility of an internalizing model differs over various substances used in isolation (i.e., alcohol, tobacco, marijuana, stimulant and depressant drug) or in combination with one another, and (5) to develop methods for integrative analysis, to utilize these methods to test Aims 1-4, and to disseminate these methods to other applied researchers. PUBLIC HEALTH RELEVANCE: Our application tests an internalizing pathway to substance use disorder over the first four decades of life. Studies of such early emerging but persistent pathways are rare but critical to efforts to design and implement effective intervention and treatment programs for youth.

描述（由申请人提供）：在本申请中，我们评估了药物使用障碍（SUD）的内在化途径，并考虑负面影响SUD的病因，这是通过合并症与涉及负面影响的疾病（即抑郁症和焦虑症的疾病）可识别的SUD的潜在表型。我们进行了综合性（次要）分析（在我们上前的项目期间进行了完善），涉及对酗酒父母的儿童的三项全国突出的纵向研究，并匹配对照组，这些对照统治着前四十年（2至38岁）。了解导致泡沫的发展途径对于设计和实施有效的青年干预和治疗计划的努力至关重要。尽管最早在2-5岁时出现了青少年物质参与风险的行为指标，但关于SUD的发育途径的理论很少考虑在学龄前年开始的风险过程。此外，很少有研究能够评估有关这些发育途径的理论。跨越生命的前四十年的纵向研究很少见，当泡沫出现，峰值和开始下降时。可用的队列或基于人群的研究通常会产生太少的病例，无法解开SUD的不同途径。因此，对高风险人群的长期纵向研究，例如酗酒父母的子女，对于阐明通往SUDS的发育途径是无价的。使用这种方法，我们追求五个具体目的：（1）定义和测试泡沫的内部化途径，并评估证据是否支持异性型连续性（即，单个潜在特征的不同发育表达（即，随时间）的单个潜在特征的不同发育表达（即，随着时间的推移）的影响，（2），（2）跨越了发展的独特，介导和外部效应的效应，并涉及互动效应，并涉及互动的效应和外部化的效应，并涉及对材料的效应和互动效应，并涉及范围的效应，并涉及范围的效应，并涉及范围的效应，并涉及范围的效应，并涉及范围的效应，并涉及范围的效应，并涉及范围的效应，并涉及范围的效应，并涉及范围。生命，（3）检查性别，父母抑郁症和上下文因素是沿着内在的负面途径的重要调节因素，而对负面的内在途径会影响SUD作为发育时机的函数，（4）检查一种内在化模型的预测效用在隔离中使用的各种物质在各种物质上是否有所不同（即，在隔离中，又是毒品，毒品，刺激性，大麻，抑郁症，（despress），大麻和抑郁症，（抑郁症）属于（抑制大麻，（集成分析的方法，利用这些方法测试目标1-4，并将这些方法传播给其他应用研究人员。公共卫生相关性：我们的申请测试在生命的头四十年中，我们的应用程序是对药物使用障碍的内部化途径。对这种早期新兴但持久途径的研究很少见，但对于设计和实施有效的干预和治疗计划的努力至关重要。