Phosphorylation and G Protein Signaling Networks Gordon Conferences

磷酸化和 G 蛋白信号转导网络 Gordon Conferences

• 批准号: 8076873
• 负责人: John Tesmer
• 金额: $ 0.3万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8076873
• 关键词: Academia; Affect; Biochemical; Biological; Cell physiology; Cells; Clinical; Communication; Disabled Persons; Disease; Fostering; Funding; G Protein-Coupled Receptor Signaling; G-Protein-Coupled Receptors; G-substrate; GTP-Binding Proteins; Genomics; Growth; Growth Factor; Health; Hormones; Hour; Human; Industry; Inflammatory; Intervention; Knowledge; Light; Mails; Minority; Molecular; Nerve; Neurotransmitters; New England; Nobel Prize; Oral; Participant; Pathway interactions; Pharmacotherapy; Phosphorylation; Physiological; Physiology; Postdoctoral Fellow; Recruitment Activity; Regulation; Request for Proposals; Research; Research Personnel; Scientist; Second Messenger Systems; Senior Scientist; Signal Pathway; Signal Transduction; Signaling Protein; Site; Smell Perception; Staging; Stimulus; Structure; Taste Perception; Therapeutic Intervention; Thinking; Universities; abstracting; base; cell growth; design; drug discovery; experience; graduate student; handicapping condition; human disease; intracellular protein transport; lectures; meetings; multidisciplinary; novel; posters; public health relevance; second messenger; sensory stimulus; symposium

DESCRIPTION (provided by applicant): The annual Gordon Research Conference (GRC) on Phosphorylation and G Protein Signaling Networks, formerly known as "Second Messengers and Protein Phosphorylation", has been a premier venue for presentation of new discoveries in signal transduction research since 1970. This proposal requests partial funding for support of the meetings to be held in 2009, 2010, and 2011. Investigators who initiated and attended the meeting from its inception are key leaders who established the field of cell signaling research, including many who received Nobel Prizes for their contributions. This GRC focuses on signaling networks underlying the action of hormones, neurotransmitters, and growth factors, as well as inflammatory and sensory stimuli. The classic themes began with and still include protein phosphorylation and G protein- dependent signaling. However, the meeting also incorporates discussions of new signaling pathways, novel mechanisms, and cellular and physiological functions. This knowledge is fundamentally and clinically important since malfunctions in these pathways contribute to health problems that affect millions worldwide and targeting the same pathways underlies much of current pharmacotherapy. The meeting is designed to foster continued growth of this important and rapidly evolving field of research. It also promotes multidisciplinary thinking and interaction among participants with an emphasis on sharing novel experimental approaches. The University of New England became the new site for this meeting in 2005, and provides an ideal rustic and handicapped-accessible venue to promote open interactions among attendees. The 2009 meeting will be held from Sunday evening, June 7 through Thursday evening, June 12. A keynote lecture by Brian Kobilka on the structure and function of G protein-coupled receptors (GPCR) will set the stage for the conference. An outstanding group of more than thirty invited speakers will discuss biochemical, structural, cell biological, genomic, physiological, and clinical approaches that together provide a front of the field view of mechanisms of cell signaling and their relationships to human disease and potential therapeutic interventions. Eight different sessions that include a discussion leader and 3-5 speakers will focus on regulation of GPCR, G protein-independent signaling of GPCR, G protein-regulating proteins, subcellular targeting of signaling proteins, downstream effectors and signaling networks, GPCR-promoted signaling into Ras-regulated networks, structural bases of G protein signaling, and drug discovery. The co- chairs will select 135 participants from applicants including representatives from industry and academia, senior scientists, and postdoctoral fellows and graduate students. A special effort will be made to recruit minority participants and industrial scientists by direct mailing. All participants will be encouraged to present posters in two hour sessions held each afternoon. The conference provides an important forum for young investigators to observe the connection between fundamental scientific inquiry, discovery, and application in the ultimate design of efficacious interventions of human disease. To provide exposure and experience for junior scientists, 8-10 abstracts will be chosen for oral presentations. Public Health Relevance: Intricate cell signaling pathways provide the lines of communication from stimuli (hormones, transmitters released from nerves, molecules that regulate cell growth, and stimuli detected as light, taste, and smell) acting on the exterior of cells to changes in cell function. Understanding these signaling pathways at the molecular level is highly relevant to understanding human physiology in health and disease. The Gordon Research Conference on Phosphorylation and G Protein Signaling Networks brings together both established and beginning investigators in this field of research in an optimum format that fosters growth and depth of knowledge at the very forefront of current and anticipated drug therapies for diseases that affect millions worldwide.

描述（由申请人提供）：一年一度的磷酸化和 G 蛋白信号网络戈登研究会议 (GRC)，以前称为“第二信使和蛋白质磷酸化”，自 1970 年以来一直是展示信号转导研究新发现的首要场所该提案要求为 2009 年、2010 年和 2011 年举行的会议提供部分资金支持。发起和出席的研究人员。会议从一开始就是建立细胞信号研究领域的主要领导人，其中包括许多因其贡献而获得诺贝尔奖的人。该 GRC 重点关注激素、神经递质和生长因子以及炎症和感觉刺激作用下的信号网络。经典主题始于并且仍然包括蛋白质磷酸化和 G 蛋白依赖性信号传导。然而，会议还讨论了新的信号通路、新机制以及细胞和生理功能。这些知识在根本上和临床上都很重要，因为这些途径的故障会导致影响全世界数百万人的健康问题，并且针对相同的途径是当前许多药物治疗的基础。此次会议旨在促进这一重要且快速发展的研究领域的持续发展。它还促进参与者之间的多学科思维和互动，重点是分享新颖的实验方法。新英格兰大学于 2005 年成为这次会议的新地点，为促进与会者之间的开放互动提供了一个理想的乡村和残疾人通道场所。 2009 年会议将于 6 月 7 日星期日晚上至 6 月 12 日星期四晚上举行。Brian Kobilka 关于 G 蛋白偶联受体 (GPCR) 结构和功能的主题演讲将为会议奠定基础。由三十多名受邀演讲者组成的杰出小组将讨论生物化学、结构、细胞生物学、基因组、生理学和临床方法，这些方法共同提供细胞信号传导机制及其与人类疾病和潜在治疗干预的关系的前沿视野。八个不同的会议，包括一名讨论主持人和 3-5 名发言者，将重点讨论 GPCR 的调节、GPCR 的 G 蛋白独立信号传导、G 蛋白调节蛋白、信号传导蛋白的亚细胞靶向、下游效应器和信号传导网络、GPCR 促进的信号传导深入研究 Ras 调节网络、G 蛋白信号传导的结构基础和药物发现。联合主席将从申请者中遴选135名参会人员，包括工业界和学术界代表、资深科学家、博士后和研究生。将特别努力通过直邮方式招募少数族裔参与者和工业科学家。我们鼓励所有参与者在每天下午举行的两小时会议上展示海报。该会议为年轻研究人员提供了一个重要的论坛，以观察基础科学探究、发现和应用在人类疾病有效干预措施的最终设计中的联系。为了给初级科学家提供接触和经验，将选择 8-10 个摘要进行口头报告。 公共健康相关性：复杂的细胞信号传导途径提供了从作用于细胞外部的刺激（激素、神经释放的递质、调节细胞生长的分子以及光、味觉和嗅觉检测到的刺激）到细胞变化的通讯线路功能。在分子水平上了解这些信号通路与了解人类健康和疾病的生理学高度相关。戈登磷酸化和 G 蛋白信号网络研究会议以最佳形式汇聚了该研究领域的知名研究人员和新晋研究人员，促进了当前和预期药物治疗最前沿的知识的增长和深度，这些药物治疗影响了全球数百万人的疾病。