PS08-002, DEV AND TESTING OF HIV PREV INTERVENTION TARGETING BLACK MSM/W

PS08-002，针对黑人 MSM/W 的 HIV 预防干预措施的开发和测试

• 批准号: 8142973
• 负责人: MARIA ISABEL FERNANDEZ
• 金额: $ 29.17万
• 依托单位: NOVA SOUTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2014-03-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8142973
• 关键词: PS08; 002; DEV; TESTING; HIV; PS08; 002; DEV; TESTING; HIV

DESCRIPTION (provided by applicant): In the United States, Blacks continue to be disproportionately impacted by HIV/AIDS. They account for only 13% of the population, yet comprise 51% of new HIV/AIDS cases diagnoses between 2001-2004.65 Black men who have sex with men (MSM), whether they identify themselves as gay, bisexual, or heterosexual are the group most severely impacted by HIV as compared to other high-risk groups. 4 This is particularly true in Chicago, an MSA that ranked fourth among U.S. metropolitan areas in AIDS case rates among Black males in 2004 (the most recent data available).4 Male to male sexual contact is the primary mode of transmission for Black men in Chicago. In 2005, 44% of AIDS cases in Chicago were among MSM and 59% of cases among MSM were Black. The proposed study addresses the HIV prevention needs of Black bisexually-active men (BMSMW) by developing and testing a theoretically based, culturally and contextually appropriate health promotion and HIV risk reduction intervention, Project POWER. POWER, designed to be delivered through face-to-face (FtF) interactions or through the internet in real time, consists of 4 weekly sessions lasting from 60 to 90 minutes. The current application builds on prior successful collaborations between the Senior (Fernandez) and junior (Hosek) investigators, the experienced research team and TaskForce (a CBO with long history of service to BMSMW in the Chicago MSA). We will first finalize the development of POWER in the two delivery modalities and adapt the health promotion control intervention (HEALTH) for BMSMW. We will then conduct a randomized control trial (RCT) to test the acceptability, feasibility and preliminary efficacy of POWER in the two delivery modalities compared with HEALTH. Using respondent driven sampling, we will recruit 300 BMSMW and randomly assign them to one of the 3 conditions. Participants will complete behavioral assessments using ACASI and provide urine and blood specimens to test for chlamydia, gonorrhea, and syphilis at baseline, immediate post and 3 month post intervention. In addition to examining reductions in unprotected anal and/or vaginal sex episodes, we will examine contextual and cultural factors that may be associated with risk and protection in BMSMW. Throughout the project period, we will collaborate with the multi-site study team by participating in scheduled conference calls, attending meetings, completing assigned tasks, preparing manuscripts, presenting at local, national and international meetings and other work of relevance to the initiative.

描述（由申请人提供）：在美国，黑人继续受艾滋病毒/艾滋病的影响不成比例。他们仅占人口的13％，但在2001-2004.65个与男性发生性关系的黑人之间占新的HIV/AIDS病例诊断的51％，无论他们是同性恋，双性恋还是异性恋者，都是与其他高风险群体相比受到HIV最严重的群体。 4在芝加哥尤其如此，芝加哥尤其如此，在2004年，黑人男性的艾滋病案例率中，MSA在美国大都市地区排名第四（最新数据）。4男性与男性性接触是芝加哥黑人男性传播的主要方式。 2005年，芝加哥的艾滋病案件中有44％在MSM中，其中59％的MSM病例是黑色。拟议的研究通过开发和测试基于理论，文化和上下文适当的健康促进以及降低艾滋病毒风险的降低干预措施，项目能力，解决黑人双性激活男性（BMSMW）的艾滋病毒预防需求。电源旨在通过面对面（FTF）互动或实时互联网交付，由40分钟到90分钟的4个每周课程组成。当前的申请基于高级（Fernandez）和Junior（Hosek）调查人员，经验丰富的研究团队和工作人员（在芝加哥MSA的BMSMW长期服务的CBO）之间的先前成功合作。我们将首先最终确定两种交付方式中的权力发展，并适应BMSMW的健康促进控制干预措施（Health）。然后，我们将进行一项随机对照试验（RCT），以测试与健康相比，功率在两种递送方式中的可接受性，可行性和初步疗效。使用受访者驱动的抽样，我们将募集300 BMSMW，并将其随机分配给3个条件之一。参与者将使用ACASI完成行为评估，并提供尿液和血液标本，以测试基线时的衣原体，淋病和梅毒，干预后立即邮政和3个月。除了检查未受保护的肛门和/或阴道性别发作的减少外，我们还将检查与BMSMW中风险和保护有关的上下文和文化因素。在整个项目期间，我们将通过参加预定的电话会议，参加会议，完成分配的任务，准备手稿，在本地，国家和国际国际会议以及其他与该计划相关的工作。