Virology

病毒学

• 批准号: 8103120
• 负责人: JOHN Christopher KAPPES
• 金额: $ 32.11万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8103120
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Arts; Biological Assay; Cell Line; Clinical; Consultations; Containment; Development; Engineering; Ensure; Environment; Equipment; Faculty; Fee-for-Service Plans; Fostering; Goals; Grant; HIV; Human Resources; Immunologics; Immunology; Knowledge; Laboratories; Life; Methods; Mission; Molecular; Molecular Biology; Nature; Pathogenesis; Phase; Plasmids; Policies; Proteins; Quality Control; Reagent; Recombinant Proteins; Recombinants; Research; Research Personnel; Resources; Safety; Services; Site; Strategic Planning; Structure; Supervision; Techniques; Technology Transfer; Training; Training and Education; Vaccine Research; Viral; Viral Vector; Work; base; cost; experience; gene cloning; genetically modified cells; laboratory facility; multidisciplinary; operation; programs; protein expression; safety education; safety practice; success; tool; virology; virus culture

The goals of the VC are to enable, broaden and enhance HIV/AIDS research by providing state-of-the-art BSL-2-3 laboratory facilities and equipment, experienced and dedicated professional staff, education, training, virology-specific research materials and assays and protein expression capabilities, all to support multidisciplinary, investigator-initiated basic and clinical HIV/AIDS research. Each of our specific aims represent significant value-added to HIV/AIDS research and the overall CFAR mission as they (i) enable live HIV research among all UAB investigators, (ii) foster the development of HIV/AIDS research by new investigators, (iii) broaden the research capabilities among CFAR faculty, and (iv) encourage research that is translational and multidisciplinary in nature. The services of VC are integral to the AIDS Center as they provide critical support to numerous multidisciplinary basic and clinical HIV/AIDS research programs. The specific aims for the VC are as follows: 1. To provide and maintain state-of-the-art BSL 2-3 laboratory facilities that are necessary to conduct "live" HIV research. 2. To provide safety education and training, and ongoing supervision for all faculty and staff that work in the BSL 2-3 Laboratory. 3. To augment AIDS research capabilities through consultation, assay-specific training, and provision of standardized assays and defined molecular and virologic reagents. 4. To develop specialized genetically engineered tools and assays, including cell lines and viral vectors, to help address new and important investigative challenges in HIV/AIDS research. 5. To continue to offer CFAR investigators the molecular biology services, reagents, and training, that allow a rapid progression from cloning of genes to structure and/or function studies of the gene product. This renewal application reflects important changes that have occurred in the academic HIV/AIDS environment nationally and at UAB since this grant was last competitively renewed. The critical services of two cores that were previously operated independently, the Central Virus Culture Core and the Molecular Biology Core, have been combined into a single core that is now referred to as the Virology Core (VC). This strategy is based on similarities in the nature of virology services offered by the two previous cores and is meant to ensure that we are able to retain and continue to provide critical value-added services, while maximizing proficient utilization of precious CFAR resources.

VC的目标是通过提供最先进的BSL-2-3来启用，扩大和增强艾滋病毒/艾滋病研究 实验室设施和设备，经验丰富且专业的专业人员，教育，培训，特定于病毒学 研究材料和测定和蛋白质表达能力，所有这些都支持多学科，研究者发起的 基本和临床艾滋病毒/艾滋病研究。我们的每个特定目标代表着对艾滋病毒/艾滋病的重要增值 研究和总体CFAR任务（i）在所有UAB调查人员中启用HIV研究，（ii）促进 新研究者（III）开发艾滋病毒/艾滋病研究，扩大了CFAR教师之间的研究能力， （iv）鼓励本质上是翻译和多学科的研究。 VC的服务是 艾滋病中心，因为它们为众多多学科基本和临床艾滋病毒/艾滋病研究提供了重要的支持 程序。 VC的具体目的如下： 1。提供和维护最先进的BSL 2-3个实验室设施 “现场”艾滋病毒研究。 2。提供安全教育和培训，并为所有工作的所有教职员工提供持续的监督 BSL 2-3实验室。 3。通过咨询，特定的培训和提供 标准化测定以及定义的分子和病​​毒学试剂。 4。开发专门的基因工程工具和测定，包括细胞系和病毒载体， 帮助应对艾滋病毒/艾滋病研究中的新重要调查挑战。 5。继续向CFAR调查人员提供分子生物学服务，试剂和培训，以便 允许从克隆基因的迅速发展到基因的结构和/或功能研究 产品。 这种续签应用反映了学术艾滋病毒/艾滋病环境中发生的重要变化 自从这笔赠款是最后一次竞争性续签以来，全国和UAB都在UAB上。两个核心的关键服务是 以前独立操作的中央病毒培养核心和分子生物学核心一直是 现在被称为病毒学核心（VC）的单个核心。该策略基于相似之处 以前两个核心提供的病毒学服务的性质，旨在确保我们能够保留和 继续提供关键的增值服务，同时最大程度地利用宝贵的CFAR资源。