Vitamin D deficiency and the severity of bronchiolitis

维生素 D 缺乏与细支气管炎的严重程度

基本信息

批准号：
8039949
负责人：
Jonathan M Mansbach
金额：
$ 13.23万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-03-01 至 2013-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8039949
关键词：
2 year old 25-hydroxyvitamin D Accident and Emergency department Accounting Admission activity Affect Area Aspirate substance Biometry Boston Bronchiolitis Caregivers Caring Child Child Care Childhood Climate Clinical Clinical Data Cohort Studies Commit Communicable Diseases Continuous Positive Airway Pressure Coughing Data Data Collection Development Enrollment Epidemiology Ethics Etiology Family Fostering Goals Guidelines Health Services Research Home environment Hospitalization Hospitalized Child Hospitals Human Immune system Infant Infection Inpatients Intensive Care Intensive Care Units Interview Intubation Lead Leadership Length of Stay Life Life Style Mentors Mucous body substance Natural Immunity Odds Ratio Patients Pediatric Hospitals Pediatrics Proteins Public Health Schools Publishing Research Research Personnel Resolution Respiratory Tract Infections Respiratory syncytial virus Risk Role Science Serum Services Severities Site Testing Time Training United States Viral Load result Vitamin D Vitamin D Deficiency Vitamin D Nutrition Wheezing Work antimicrobial base career cathelicidin cost experience follow-up hazard infancy instructor medical attention medical schools meetings multidisciplinary pathogen patient oriented prospective virology ward

项目摘要

DESCRIPTION (provided by applicant): Candidate: Jonathan Mansbach, MD is an Instructor in Pediatrics at Harvard Medical School at Children's Hospital Boston (CHB). He supervises an inpatient pediatric service and works with his mentor, Carlos A. Camargo, MD, DrPH, conducting bronchiolitis research. As Co-PIs, they recently completed two Emergency Department (ED)-based bronchiolitis studies: 1) a 37-site cohort study with data collection on 2,847 children, and 2) a 14-site virology study with data collection on 277 children. He also has published health services research on bronchiolitis. Finally, he is a Co-Investigator on U01 AI67693 (Camargo, PI), a 15-site study of 2,250 inpatients age <2 years with bronchiolitis. This K23 application will build directly on this U01 project. Training: In order to meet his career goals of: 1) becoming a national leader of bronchiolitis research; 2) understanding the association between vitamin D deficiency and severity of bronchiolits; and 3) becoming an independent patient-oriented investigator, Dr Mansbach requires more training in epidemiology, biostatistics, vitamin D /nutrition, and infectious disease. Therefore, he proposes to take masters-level courses at the Harvard School of Public Health in all of these areas. He also will take classes in leadership development and the ethical conduct of research. Science: Our research has shown that vitamin D deficiency is associated with increased respiratory infections in the first 3 months of life and increased risk of childhood wheezing. The scientific portion of this K23 application focuses on the association between vitamin D deficiency in infancy and the severity of bronchiolitis. Dr Mansbach proposes to conduct a study of children with bronchiolitis presenting to CHB to examine if vitamin D deficiency is associated with: 1) the level of care a child requires - sent home from the ED, ward admission, or intensive care unit admission; 2) the viral load of respiratory syncytial virus; and 3) the duration of cough and hospital length of stay. Using 75 hospitalized patients from the U01, and 150 newly-enrolled ED patients for this K23 project, we will have 80% power to detect reasonable odds ratios, effect sizes, and hazard ratios for each of the hypotheses. Summary: A multidisciplinary team of experienced mentors and consultants have committed to help Dr Mansbach fulfill the personal and scientific goals of this K23 application. The results from the scientific portion of this proposal may provide data that will change the care of children and directly lead to R01 applications.

描述（由申请人提供）：候选人：医学博士乔纳森·曼斯巴赫（Jonathan Mansbach）是波士顿儿童医院（CHB）的哈佛医学院儿科教练。他监督住院儿科服务，并与他的导师Carlos A. Camargo，医学博士，DRPH，进行支气管炎研究。作为Co-Pis，他们最近完成了两个基于急诊科（ED）的支气管炎研究：1）一项37个地点队列研究，对2,847名儿童进行数据收集，以及2）14个地点病毒学研究，并收集了277名儿童的数据。他还发表了有关支气管炎的卫生服务研究。最后，他是U01 AI67693（Camargo，pi）的共同研究器，这是一项15次研究的研究，对2,250名患者年龄<2岁，患有支气管炎。该K23应用程序将直接基于此U01项目。培训：为了实现他的职业目标：1）成为支气管炎研究的国家领导者； 2）了解维生素D缺乏和细支气管的严重程度之间的关联； 3）成为独立的以患者为导向的研究者，曼斯巴赫博士需要在流行病学，生物统计学，维生素D /营养和传染病方面进行更多培训。因此，他建议在所有这些领域的哈佛公共卫生学院上硕士课程。他还将参加领导力发展和研究道德行为的课程。科学：我们的研究表明，维生素D缺乏症与生命的前三个月中的呼吸道感染增加以及儿童期喘息的风险增加有关。该K23应用的科学部分着重于婴儿期维生素D缺乏与细支气管炎的严重程度之间的关联。曼斯巴赫（Mansbach）博士建议对CHB进行细支气管炎的儿童进行研究，以检查维生素D缺乏症是否与：1）儿童需要的护理水平 - 从ED，病房入院或重症监护病房入院； 2）呼吸综合病毒的病毒负荷； 3）咳嗽和住院时间的持续时间。使用来自U01的75例住院患者，该项目为150名新入选的ED患者，我们将拥有80％的功率来检测每个假设的合理优势比，效果大小和危害比率。摘要：由经验丰富的导师和顾问组成的跨学科团队已致力于帮助Mansbach博士实现此K23应用程序的个人和科学目标。该提案科学部分的结果可能会提供数据，这些数据将改变儿童的护理并直接导致R01应用。