Vitamin D deficiency and the severity of bronchiolitis

维生素 D 缺乏与细支气管炎的严重程度

基本信息

批准号：
8039949
负责人：
Jonathan M Mansbach
金额：
$ 13.23万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-03-01 至 2013-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8039949
关键词：
2 year old 25-hydroxyvitamin D Accident and Emergency department Accounting Admission activity Affect Area Aspirate substance Biometry Boston Bronchiolitis Caregivers Caring Child Child Care Childhood Climate Clinical Clinical Data Cohort Studies Commit Communicable Diseases Continuous Positive Airway Pressure Coughing Data Data Collection Development Enrollment Epidemiology Ethics Etiology Family Fostering Goals Guidelines Health Services Research Home environment Hospitalization Hospitalized Child Hospitals Human Immune system Infant Infection Inpatients Intensive Care Intensive Care Units Interview Intubation Lead Leadership Length of Stay Life Life Style Mentors Mucous body substance Natural Immunity Odds Ratio Patients Pediatric Hospitals Pediatrics Proteins Public Health Schools Publishing Research Research Personnel Resolution Respiratory Tract Infections Respiratory syncytial virus Risk Role Science Serum Services Severities Site Testing Time Training United States Viral Load result Vitamin D Vitamin D Deficiency Vitamin D Nutrition Wheezing Work antimicrobial base career cathelicidin cost experience follow-up hazard infancy instructor medical attention medical schools meetings multidisciplinary pathogen patient oriented prospective virology ward

项目摘要

DESCRIPTION (provided by applicant): Candidate: Jonathan Mansbach, MD is an Instructor in Pediatrics at Harvard Medical School at Children's Hospital Boston (CHB). He supervises an inpatient pediatric service and works with his mentor, Carlos A. Camargo, MD, DrPH, conducting bronchiolitis research. As Co-PIs, they recently completed two Emergency Department (ED)-based bronchiolitis studies: 1) a 37-site cohort study with data collection on 2,847 children, and 2) a 14-site virology study with data collection on 277 children. He also has published health services research on bronchiolitis. Finally, he is a Co-Investigator on U01 AI67693 (Camargo, PI), a 15-site study of 2,250 inpatients age <2 years with bronchiolitis. This K23 application will build directly on this U01 project. Training: In order to meet his career goals of: 1) becoming a national leader of bronchiolitis research; 2) understanding the association between vitamin D deficiency and severity of bronchiolits; and 3) becoming an independent patient-oriented investigator, Dr Mansbach requires more training in epidemiology, biostatistics, vitamin D /nutrition, and infectious disease. Therefore, he proposes to take masters-level courses at the Harvard School of Public Health in all of these areas. He also will take classes in leadership development and the ethical conduct of research. Science: Our research has shown that vitamin D deficiency is associated with increased respiratory infections in the first 3 months of life and increased risk of childhood wheezing. The scientific portion of this K23 application focuses on the association between vitamin D deficiency in infancy and the severity of bronchiolitis. Dr Mansbach proposes to conduct a study of children with bronchiolitis presenting to CHB to examine if vitamin D deficiency is associated with: 1) the level of care a child requires - sent home from the ED, ward admission, or intensive care unit admission; 2) the viral load of respiratory syncytial virus; and 3) the duration of cough and hospital length of stay. Using 75 hospitalized patients from the U01, and 150 newly-enrolled ED patients for this K23 project, we will have 80% power to detect reasonable odds ratios, effect sizes, and hazard ratios for each of the hypotheses. Summary: A multidisciplinary team of experienced mentors and consultants have committed to help Dr Mansbach fulfill the personal and scientific goals of this K23 application. The results from the scientific portion of this proposal may provide data that will change the care of children and directly lead to R01 applications.

描述（由申请人提供）：候选人：Jonathan Mansbach，医学博士是哈佛医学院波士顿儿童医院 (CHB) 的儿科讲师。他负责监督住院儿科服务，并与他的导师 Carlos A. Camargo（医学博士、公共卫生博士）合作进行细支气管炎研究。作为联合首席研究员，他们最近完成了两项基于急诊科 (ED) 的细支气管炎研究：1) 一项 37 个中心的队列研究，收集了 2,847 名儿童的数据；2) 一项 14 个中心的病毒学研究，收集了 277 名儿童的数据。他还发表了有关细支气管炎的健康服务研究。最后，他还是 U01 AI67693（卡马戈，PI）的联合研究员，这是一项 15 个地点的研究，涉及 2,250 名年龄 <2 岁的细支气管炎住院患者。该 K23 应用程序将直接基于该 U01 项目构建。培训：为了实现他的职业目标：1）成为全国细支气管炎研究的带头人； 2) 了解维生素 D 缺乏与细支气管炎严重程度之间的关系； 3) 成为一名以患者为中心的独立研究者，Mansbach 博士需要接受更多流行病学、生物统计学、维生素 D/营养和传染病方面的培训。因此，他建议在哈佛大学公共卫生学院学习所有这些领域的硕士学位课程。他还将参加领导力发展和研究道德行为方面的课程。科学：我们的研究表明，维生素 D 缺乏与出生后前 3 个月内呼吸道感染的增加以及儿童喘息的风险增加有关。该 K23 应用的科学部分重点关注婴儿期维生素 D 缺乏与细支气管炎严重程度之间的关联。 Mansbach 博士提议对向 CHB 就诊的患有细支气管炎的儿童进行一项研究，以检查维生素 D 缺乏是否与以下因素相关：1) 儿童所需的护理水平 - 从急诊室送回家、入住病房或入住重症监护室； 2)呼吸道合胞病毒的病毒载量； 3) 咳嗽持续时间和住院时间。在这个 K23 项目中使用 U01 的 75 名住院患者和 150 名新入组的 ED 患者，我们将有 80% 的功效来检测每个假设的合理比值比、效应大小和风险比。摘要：由经验丰富的导师和顾问组成的多学科团队致力于帮助 Mansbach 博士实现 K23 申请的个人和科学目标。该提案的科学部分的结果可能会提供改变儿童护理方式的数据，并直接导致 R01 的应用。