Resting State Functional Connectivity and Interhemispheric Interactions in Healt*

健康中的静息状态功能连接和半球间相互作用*

• 批准号: 8120243
• 负责人: ALEXANDRE R CARTER
• 金额: $ 13.59万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8120243
• 关键词: Behavioral; Body part; Brain; Brain Injuries; Brain Part; Brain imaging; Clinical; Development Plans; Doctor of Philosophy; Functional Imaging; Functional Magnetic Resonance Imaging; Goals; Hand; Human; Ipsilateral; Magnetic Resonance Imaging; Measures; Mentors; Molecular; Motor Cortex; Movement; Neurologist; Neuronal Plasticity; Neurorehabilitation; Neurosciences; Patients; Performance; Preparation; Recovery; Research; Research Activity; Research Project Grants; Rest; Saints; Side; Signal Transduction; Site; Stroke; System; Techniques; Testing; Training; United States; Universities; Washington; career; career development; chronic stroke; computational neuroscience; disability; experience; indexing; information processing; meetings; motor control; novel; public health relevance; repaired

DESCRIPTION (provided by applicant): Project Summary: The candidate is an MD/PhD with an excellent background in the molecular and cellular mechanisms of neuronal plasticity whose short-term goal is to make the transition to functional brain imaging and systems neuroscience. The candidate is also a trained clinical neurologist and his long-term career goal is to investigate the human brain's endogenous mechanisms for recovery and self-repair after stroke. The research project is driven by the realization that the dominant localizationist perspective cannot provide the answers we seek to understand brain function. Studying interhemispheric interactions is an important step toward understanding distributed brain networks. Using the novel technique of resting state functional connectivity MRI and traditional fMRI approaches will be an important step in this direction. In particular we hypothesize that resting state functional connectivity MRI can be used as an index ofthe amount of information processing taking place between the hemispheres and predicts behavioral performance. We will test this hypothesis by 1) determining resting connectivity across motor cortex in chronic stroke patients and in professional pianists compared to healthy controls and correlating connectivity with measures of hand dexterity. 2) Resting connectivity across motor cortex representing body parts of capable of different levels of unilateral movement will be studied. 3) BOLD fMRI signals generated in preparation for a unilateral hand movement will be used to study the importance of the ipsilateral BOLD signal for movement preparation and execution. Dr. Carter's career development plan will be mentored by Dr. Maurizio Corbetta, a leader in clinical neurorehabilitation and functional imaging. Consultants chosen for their expertise in functional imaging, motor control systems and computational neuroscience will provide additional guidance. Supervised research activities will be combined with didactic coursework tailored to meet Dr. Carter's needs and provide an intensive training experience. The project will be carried out at Washington University in Saint Louis, a premier site for brain imaging research. Public Health Relevance: Stroke is the leading cause of long-term disability in the United States and neurorehabilitation strategies remain woefully inadequate due to an incomplete understanding of how different parts of the brain interact with each other. The purpose of this proposal is to study how the two sides of the brain influence each other in the hope that we will develop new strategies to help people recover from brain injuries like stroke.

描述（由申请人提供）：项目摘要：候选人是神经元可塑性的分子和细胞机制的MD/PHD，其短期目标是使功能性脑成像和系统神经科学的过渡。候选人也是一名受过训练的临床神经科医生，他的长期职业目标是调查人类脑部恢复和中风后自我修复的内源性机制。研究项目是由意识到主导的本地化观点无法提供我们寻求理解大脑功能的答案的驱动的。研究半球间相互作用是迈向理解分布式大脑网络的重要步骤。使用静止状态功能连通性MRI和传统fMRI方法的新技术将是朝这个方向迈出的重要一步。特别是我们假设静止状态功能连通性MRI可以用作半球之间发生的信息处理量的索引，并预测行为性能。我们将通过1）确定慢性中风患者和专业钢琴家的静止连通性与健康对照组相比，并将连通性与手动敏捷度量相关联。 2）将研究代表能够不同水平单侧运动的身体部位的运动皮层的静止连通性。 3）为单方面移动准备而产生的大胆FMRI信号将用于研究同侧粗体信号在运动准备和执行方面的重要性。 Carter博士的职业发展计划将由临床神经康复和功能成像领域的领导者Maurizio Corbetta博士进行指导。因其功能成像，运动控制系统和计算神经科学方面的专业知识而选择的顾问将提供其他指导。监督的研究活动将与量身定制的教学课程相结合，以满足卡特博士的需求并提供深入的培训经验。该项目将在圣路易斯的华盛顿大学进行，这是大脑成像研究的主要网站。 公共卫生相关性：中风是美国长期残疾的主要原因，由于对大脑的不同部位之间如何相互相互作用，由于不完整的了解，神经康复策略仍然严重不足。该提案的目的是研究大脑的双方如何相互影响，希望我们将制定新的策略，以帮助人们从中风等脑损伤中恢复过来。