Development of Anxiety Models in Drosophila

果蝇焦虑模型的发展

基本信息

批准号：
8076310
负责人：
Gregg W Roman
金额：
$ 7.5万
依托单位：
UNIVERSITY OF HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-05-24 至 2013-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8076310
关键词：
Affect Aggressive behavior Animal Experiments Animal Model Animals Anxiety Anxiety Disorders Aversive Stimulus Behavior Behavioral Behavioral Paradigm Biological Models Candidate Disease Gene Carbon Dioxide Collection Complex Development Disease Dissection Drosophila genus Drosophila melanogaster Emotional Environmental Risk Factor Evolution Foundations Fright Genes Genetic Genetic Models Goals Growth Health Human Invertebrates Knowledge Lead Learning Measures Mental disorders Modeling Molecular Motor Activity Nature Neuraxis Neurobiology Neurons Neuropil Operant Conditioning Phase Predisposition Research Rodent Role Shelter facility Stimulus Susceptibility Gene System Testing Time Transgenic Organisms Vertebrates Visual Work base behavior measurement behavior test classical conditioning comparative endophenotype fly genetic resource neurogenetics novel preference public health relevance relating to nervous system research study response stressor tool

项目摘要

DESCRIPTION (provided by applicant): Anxiety Disorders are the most common mental illness in the US. Currently it is believed that many of these disorders are be triggered by environmental factors, but a predisposition to the disorder is strongly controlled by genetics factors. The ability to identify novel anxiety susceptibility genes in humans has been limited in part by the absence of endophenotypes for anxiety, and by the complexity of the constellation of diseases that comprise anxiety disorders. Since anxiety and fear represent ancient and evolutionarily conserved emotional states, animal models should be extremely valuable in dissecting the underlying neurobiology of anxiety and for identifying candidate genes. Simple animal models will allow for the identification of "core" anxiety responses that have since expanded and multiplied through evolution. A core anxiety response would also illuminate possible endophenotypes for anxiety disorders. The proposed experiments will identify novel behavioral responses to anxiogenic stimuli in Drosophila melanogaster. In these experiments the animals will be subjected to innately and conditionally aversive stimuli, and their responses in three behavioral measures will be determined. Drosophila is an extremely powerful genetic model system for the dissection of the behavioral and neurogenetic underpinnings of anxiety-like responses. Ultimately, the knowledge gained on these responses in this simple and agile genetic model system will permit the development of new and more detailed hypothesis on how different forms of anxiety may have evolved, which genes control the magnitude of responses, possible endophenotypes, and the potential functions and causes of pathological anxiety states in humans. PUBLIC HEALTH RELEVANCE: The proposed project investigates how anxiety-producing stimuli lead to changes in the behavior of Drosophila melanogaster in a novel open field arena. The studies will produce a foundation for further dissecting the genetic and neural basis of anxiety in both invertebrates and vertebrates.

描述（由申请人提供）：焦虑症是美国最常见的精神疾病。目前，人们认为其中许多疾病是由环境因素触发的，但是对该疾病的倾向是由遗传因素强烈控制的。鉴定人类中新型焦虑敏感基因的能力受到部分限制，部分原因是缺乏焦虑症的内表型，以及构成焦虑症的疾病星座的复杂性。由于焦虑和恐惧代表了古代和进化保守的情绪状态，因此动物模型在剖析焦虑的潜在神经生物学和识别候选基因方面应该非常有价值。简单的动物模型将允许识别自那以后通过进化扩展和乘以的“核心”焦虑反应。核心焦虑反应还将阐明焦虑症的可能内表型。提出的实验将确定果蝇果蝇中对抗焦虑刺激的新型行为反应。在这些实验中，动物将对天生和有条件地厌恶刺激进行，并确定它们在三种行为措施中的反应。果蝇是一种非常强大的遗传模型系统，用于解剖类似焦虑的反应的行为和神经遗传基础。最终，在这个简单而敏捷的遗传模型系统中获得的这些反应的知识将允许发展有关不同形式的焦虑可能如何发展的新的，更详细的假设，这些假设可以控制响应的大小，可能的内型型和潜力，以及潜在的潜力以及潜力的幅度。人类病理焦虑状态的功能和原因。公共卫生相关性：拟议的项目调查了产生焦虑的刺激是如何导致果蝇中果蝇在一个新型的开放式领域的行为变化。这项研究将为无脊椎动物和脊椎动物的焦虑症进一步剖析基础。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Modeling novelty habituation during exploratory activity in Drosophila.

模拟果蝇探索活动期间的新奇习惯。

DOI：
10.1016/j.beproc.2013.04.005
发表时间：
2013
期刊：
Behavioural processes
影响因子：
1.3
作者：
Soibam,Benjamin;Shah,Shishir;Gunaratne,GemunuH;Roman,GreggW
通讯作者：
Roman,GreggW

Open-field arena boundary is a primary object of exploration for Drosophila.

DOI：
10.1002/brb3.36
发表时间：
2012-03
期刊：
BRAIN AND BEHAVIOR
影响因子：
3.1
作者：
Soibam, Benjamin;Mann, Monica;Liu, Lingzhi;Tran, Jessica;Lobaina, Milena;Kang, Yuan Yuan;Gunaratne, Gemunu H.;Pletcher, Scott;Roman, Gregg
通讯作者：
Roman, Gregg

Drosophila increase exploration after visually detecting predators.

DOI：
10.1371/journal.pone.0180749
发表时间：
2017
期刊：
PloS one
影响因子：
3.7
作者：
de la Flor M;Chen L;Manson-Bishop C;Chu TC;Zamora K;Robbins D;Gunaratne G;Roman G
通讯作者：
Roman G