Influence of placental structure and function on birth weight in the Philippines

菲律宾胎盘结构和功能对出生体重的影响

• 批准号: 8111206
• 负责人: Christopher Kuzawa
• 金额: $ 7.65万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8111206
• 关键词: Accounting; Adult; Age; Back; Biological Markers; Biology; Birth; Birth Weight; Child; Collection; Communication; Data; Enrollment; Environment; Epigenetic Process; Evaluation; Event; Fetal Growth; Fetal Growth Retardation; Fetus; Follow-Up Studies; Funding; Gene Expression; Gene Silencing; Generations; Goals; Health; Health Surveys; Hospitals; Individual; Inequality; Institution; Labor Onset; Laboratories; Life; Link; Low Birth Weight Infant; Mediator of activation protein; Medical; Mothers; Newborn Infant; Nutrition Surveys; Nutritional; Outcome; Participant; Pathway interactions; Personal Satisfaction; Philippines; Pilot Projects; Placenta; Pregnancy; Preparation; Process; Protocols documentation; Proxy; Public Hospitals; Recording of previous events; Records; Research; Research Infrastructure; Research Personnel; Role; Sampling; Shipping; Ships; Skin; Stress; Structure; System; Testing; Tissue Sample; Transcend; Variant; Woman; Women' s Health; Work; cohort; design; experience; fetus nutrition; follow-up; health inequalities; infancy; insight; intergenerational; member; morphometry; mother nutrition; nutrition; offspring; population based; pregnant; public health relevance; social inequality; transmission process; young adult; young mother

DESCRIPTION (provided by applicant): It is now well-established that nutritionally stressful early environments can set up the transgenerational transmission of lower birth weight in offspring, which in turn sets that individual on a compromised lifecourse health and functional trajectory. This research is highlighting an important means by which social inequality gets "under the skin", and may even be transmitted across generations. Most of this work has used birth weight records as a proxy for maternal-gestational conditions, and as such, the pathways that might account for the transgenerational transmission of inequality are poorly understood. The placenta, as the mediator of maternal nutrition and fetal growth, is a good candidate mechanism. We currently have NSF support for 3 years of new fieldwork with our large birth cohort in the Philippines, which will track new pregnancies in the original cohort members (now young adults) and collect birth weights and other information on their newborn offspring (generation 3). The intent of this R03 is to piggy back a field test and pilot analysis of placental collection onto this study. All young mothers targeted in this proposal are original birth cohort members in the Cebu Longitudinal Health and Nutrition Survey (CLHNS), a large population-based multi-generational study in the Philippines that has followed the same group of individuals since their mothers were pregnant with them 26 years ago. As these original cohort members are now of child-bearing age, we have a unique opportunity to use the rich longitudinal nutritional histories available for each young mother to evaluate an important candidate mechanism for the transmission of health inequality to their newborn offspring. We will collect 30 placentas from women selected from the extremes of the original birth cohort's birth weight distribution in order to troubleshoot collection, processing, and shipping protocols, to allow preliminary tests of our hypotheses, and to generate data to allow calculation of effect sizes for power calculations when designing an R01 to continue follow up of generation 3 newborns. Although the strength of the Cebu Study is its rich, longitudinal and multi-generational design, our team includes expertise that will allow evaluation of the key candidate placental processes that could be involved in transgenerational transmission between mother and offspring, including changes in morphometry and epigenetic changes that could modify expression of genes that regulate fetal growth. Our ultimate goal is to justify an expanded study of the transgenerational transmission of health inequality via gestational pathways in the Cebu cohort. Adding a placental component to an already robust longitudinal record of panel data promises important insights into the processes that underlie variation in birth weight, and by extension, the many adult outcomes downstream of birth weight. PUBLIC HEALTH RELEVANCE: New evidence suggests that the impact of social inequality on health can transcend the present generation and even influence health and well-being in offspring. This study proposes to study how a woman's health and nutritional history influence fetal growth via effects on the placenta, which serves as the interface between the mother and fetus. The proposed study would be the first to explore these questions in mothers who have been followed continuously since prior to their own births, when their pregnant mothers (the grandmothers) were first enrolled in 1983.

描述（由申请人提供）：现已明确，营养紧张的早期环境可能会导致后代出生体重较低，从而导致个体生命周期健康和功能轨迹受到损害。这项研究强调了社会不平等“深入骨髓”、甚至可能代代相传的一个重要途径。这项工作大部分都使用出生体重记录作为孕产妇妊娠状况的代表，因此，人们对不平等跨代传播的途径知之甚少。胎盘作为母体营养和胎儿生长的调节者，是一个很好的候选机制。目前，我们得到了 NSF 的支持，对菲律宾的大型出生队列进行了为期 3 年的新实地工作，该工作将跟踪原始队列成员（现在是年轻人）的新怀孕情况，并收集其新生儿后代（第 3 代）的出生体重和其他信息。 R03 的目的是将胎盘采集的现场测试和初步分析纳入本研究。该提案针对的所有年轻母亲都是宿务纵向健康和营养调查 (CLHNS) 的原始出生队列成员，这是菲律宾一项基于人口的大型多代研究，自母亲怀孕以来一直跟踪同一组个体。 26年前的他们。由于这些最初的队列成员现在已达到育龄，我们有一个独特的机会，利用每位年轻母亲可获得的丰富的纵向营养史来评估将健康不平等传递给新生后代的重要候选机制。我们将从原始出生队列出生体重分布极端的女性中收集 30 个胎盘，以便对收集、处理和运输方案进行故障排除，以便对我们的假设进行初步测试，并生成数据以计算效应大小设计 R01 以继续跟踪第 3 代新生儿时的功率计算。尽管宿务研究的优势在于其丰富的、纵向的和多代的设计，但我们的团队拥有专业知识，可以评估可能参与母亲和后代之间跨代传播的关键候选胎盘过程，包括形态测量和表观遗传的变化可能改变调节胎儿生长的基因表达的变化。我们的最终目标是证明宿务队列中健康不平等通过妊娠途径跨代传播的扩大研究的合理性。将胎盘成分添加到已经强大的面板数据纵向记录中，可以提供对出生体重变化背后的过程的重要见解，进而深入了解出生体重下游的许多成人结果。 公共卫生相关性：新证据表明，社会不平等对健康的影响可能超越当代人，甚至影响后代的健康和福祉。这项研究旨在研究女性的健康和营养史如何通过对胎盘的影响来影响胎儿的生长，胎盘是母亲和胎儿之间的界面。这项拟议的研究将是第一个针对母亲们探讨这些问题的研究，这些母亲自出生前就一直受到跟踪，当时她们怀孕的母亲（祖母）于 1983 年首次入组。

项目成果

Global population variation in placental size and structure: Evidence from Cebu, Philippines.

全球人口胎盘大小和结构的差异：来自菲律宾宿务的证据。

• DOI: 10.1016/j.placenta.2019.08.076
• 发表时间: 2019
• 期刊: Placenta
• 影响因子: 3.8
• 作者: Rutherford,JulienneN;VictoriaAdeMartelly;Ragsdale,HaleyB;Avila,JosephineL;Lee,NanetteR;Kuzawa,ChristopherW
• 通讯作者: Kuzawa,ChristopherW