Influence of placental structure and function on birth weight in the Philippines

菲律宾胎盘结构和功能对出生体重的影响

• 批准号: 8111206
• 负责人: Christopher Kuzawa
• 金额: $ 7.65万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8111206
• 关键词: Accounting; Adult; Age; Back; Biological Markers; Biology; Birth; Birth Weight; Child; Collection; Communication; Data; Enrollment; Environment; Epigenetic Process; Evaluation; Event; Fetal Growth; Fetal Growth Retardation; Fetus; Follow-Up Studies; Funding; Gene Expression; Gene Silencing; Generations; Goals; Health; Health Surveys; Hospitals; Individual; Inequality; Institution; Labor Onset; Laboratories; Life; Link; Low Birth Weight Infant; Mediator of activation protein; Medical; Mothers; Newborn Infant; Nutrition Surveys; Nutritional; Outcome; Participant; Pathway interactions; Personal Satisfaction; Philippines; Pilot Projects; Placenta; Pregnancy; Preparation; Process; Protocols documentation; Proxy; Public Hospitals; Recording of previous events; Records; Research; Research Infrastructure; Research Personnel; Role; Sampling; Shipping; Ships; Skin; Stress; Structure; System; Testing; Tissue Sample; Transcend; Variant; Woman; Women' s Health; Work; cohort; design; experience; fetus nutrition; follow-up; health inequalities; infancy; insight; intergenerational; member; morphometry; mother nutrition; nutrition; offspring; population based; pregnant; public health relevance; social inequality; transmission process; young adult; young mother

DESCRIPTION (provided by applicant): It is now well-established that nutritionally stressful early environments can set up the transgenerational transmission of lower birth weight in offspring, which in turn sets that individual on a compromised lifecourse health and functional trajectory. This research is highlighting an important means by which social inequality gets "under the skin", and may even be transmitted across generations. Most of this work has used birth weight records as a proxy for maternal-gestational conditions, and as such, the pathways that might account for the transgenerational transmission of inequality are poorly understood. The placenta, as the mediator of maternal nutrition and fetal growth, is a good candidate mechanism. We currently have NSF support for 3 years of new fieldwork with our large birth cohort in the Philippines, which will track new pregnancies in the original cohort members (now young adults) and collect birth weights and other information on their newborn offspring (generation 3). The intent of this R03 is to piggy back a field test and pilot analysis of placental collection onto this study. All young mothers targeted in this proposal are original birth cohort members in the Cebu Longitudinal Health and Nutrition Survey (CLHNS), a large population-based multi-generational study in the Philippines that has followed the same group of individuals since their mothers were pregnant with them 26 years ago. As these original cohort members are now of child-bearing age, we have a unique opportunity to use the rich longitudinal nutritional histories available for each young mother to evaluate an important candidate mechanism for the transmission of health inequality to their newborn offspring. We will collect 30 placentas from women selected from the extremes of the original birth cohort's birth weight distribution in order to troubleshoot collection, processing, and shipping protocols, to allow preliminary tests of our hypotheses, and to generate data to allow calculation of effect sizes for power calculations when designing an R01 to continue follow up of generation 3 newborns. Although the strength of the Cebu Study is its rich, longitudinal and multi-generational design, our team includes expertise that will allow evaluation of the key candidate placental processes that could be involved in transgenerational transmission between mother and offspring, including changes in morphometry and epigenetic changes that could modify expression of genes that regulate fetal growth. Our ultimate goal is to justify an expanded study of the transgenerational transmission of health inequality via gestational pathways in the Cebu cohort. Adding a placental component to an already robust longitudinal record of panel data promises important insights into the processes that underlie variation in birth weight, and by extension, the many adult outcomes downstream of birth weight. PUBLIC HEALTH RELEVANCE: New evidence suggests that the impact of social inequality on health can transcend the present generation and even influence health and well-being in offspring. This study proposes to study how a woman's health and nutritional history influence fetal growth via effects on the placenta, which serves as the interface between the mother and fetus. The proposed study would be the first to explore these questions in mothers who have been followed continuously since prior to their own births, when their pregnant mothers (the grandmothers) were first enrolled in 1983.

描述（由申请人提供）：现在已经有良好的营养压力的早期环境可以在后代中建立较低出生体重的转世传播，而后者又设置了该人在遭受损害的生命性健康和功能轨迹上的个人。这项研究强调了社会不平等“在皮肤下”的重要手段，甚至可能在几代人之间传播。这项工作的大部分都将出生体重记录作为母亲妊娠条件的替代，因此，理解不平等的跨代传播的途径知之甚少。胎盘作为母体营养和胎儿生长的介体，是一种很好的候选机制。目前，我们在菲律宾的大型出生队列中为NSF提供了3年的新现场工作，该公司将追踪原始队列成员（现为年轻人）的新怀孕，并收集有关其新生儿后代的出生体重和其他信息（3代生）。该R03的目的是将胎盘收集的现场测试和试点分析备份到这项研究中。该提案中针对的所有年轻母亲都是宿雾纵向健康和营养调查（CLHNS）的原始出生队列成员，这是一项大型基于人群的多代研究，在菲律宾，自26年前的母亲怀孕以来，一直跟随同一群人。由于这些原始的队列成员现在是育龄的年龄，因此我们有一个独特的机会，可以使用可用于每个年轻母亲的丰富纵向营养历史，以评估一种重要的候选机制，用于将健康不平等传播到新生儿后代。我们将从原始出生队列的出生体重分布的极端中选择的妇女收集30个胎盘，以解决收集，处理和运输方案的故障排除，以允许对我们的假设进行初步测试，并生成数据以允许计算效应尺寸以进行电源计算时，在设计R01时继续使用R01，以继续进行R01，以继续进行3型新生儿的跟进。尽管宿雾研究的实力是其丰富，纵向和多代设计，但我们的团队包括专业知识，可以评估可能涉及母亲和后代之间转世传播的关键候选胎盘过程，包括形态测定法和表观遗传学变化的变化，这些变化可能会改变调节胎儿生长的基因表达。我们的最终目标是通过宿雾队列中的妊娠途径来证明对健康不平等的传播的扩展研究是合理的。将胎盘成分添加到本来已经有力的面板数据纵向记录中，有望对出生体重变化的过程以及随着出生体重下游的许多成年结果的差异的重要见解。 公共卫生相关性：新的证据表明，社会不平等对健康的影响可以超越现代，甚至影响后代的健康和福祉。这项研究建议研究女性的健康和营养史如何通过对胎盘的影响来影响胎儿的生长，胎盘是母亲与胎儿之间的界面。拟议的研究将是第一个在母亲中探索这些问题的人，这些母亲自从出生之前就一直受到关注，当时他们的怀孕母亲（祖母（祖母）于1983年首次入学。

项目成果

Global population variation in placental size and structure: Evidence from Cebu, Philippines.

全球人口胎盘大小和结构的差异：来自菲律宾宿务的证据。

• DOI: 10.1016/j.placenta.2019.08.076
• 发表时间: 2019
• 期刊: Placenta
• 影响因子: 3.8
• 作者: Rutherford,JulienneN;VictoriaAdeMartelly;Ragsdale,HaleyB;Avila,JosephineL;Lee,NanetteR;Kuzawa,ChristopherW
• 通讯作者: Kuzawa,ChristopherW