Breast Cancer Risk Stratification with Resonant Electrical Impedance Spectroscopy
使用共振电阻抗谱进行乳腺癌风险分层
基本信息
- 批准号:7391203
- 负责人:
- 金额:$ 16.98万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-04-01 至 2009-03-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAgeAlgorithmsBackBiological Neural NetworksBiopsyBreastBreast Cancer DetectionBreast Cancer Early DetectionCategoriesClassificationClinicalDataData SetDevicesDiagnosticDiagnostic ImagingDiagnostic ProcedureDigital MammographyDiseaseDropsEffectivenessEquipmentEvaluationExposure toFoundationsFrequenciesGeneral PopulationGenetic ProgrammingGoldHigh Risk WomanHumanImageImaging technologyIncidenceInjection of therapeutic agentMachine LearningMagnetic Resonance ImagingMalignant NeoplasmsMammary Gland ParenchymaMammographyMeasurementMeasuresMedicalMethodologyModalityModificationNoiseNumbersOffice VisitsPalpablePatientsPerformancePersonsPhasePlacementPlaguePopulationPremenopauseProceduresPropertyProspective StudiesPublic HealthPurposeRadiationRateRecommendationRecruitment ActivityRiskRoleScanningScreening procedureSensitivity and SpecificitySignal TransductionSiteSkinSpecificitySpectrum AnalysisStandards of Weights and MeasuresStratificationSubgroupSurfaceSystemTechniquesTechnologyTestingTissuesTrainingWestern WorldWomanWomen&aposs Groupage groupbasebreast densitycancer riskcostdesignelectric impedancefollow-upimprovedin vivomalignant breast neoplasmnovel strategiesolder womenprototypesensortool
项目摘要
DESCRIPTION (provided by applicant): Although risk for developing breast cancer at an earlier age is low in a substantial fraction of person-years lost it is attributed to women under the age of 40 who die from this disease. Unfortunately, screening mammography, the "gold standard" and accepted practice over the age of 40 for breast cancer detection, performs poorly in younger women and combined with radiation risk and expected low yield resulted in the recommendation that annual screening in the general population is not recommended below this age. Alternative imaging modalities exist (e.g. MRI, US), however, these techniques are not being used for this purpose for a variety of reasons. It would greatly facilitate breast cancer detection in younger women if an inexpensive, easy to use, widely available technology was available to pre-screen women and determine who would most likely benefit from more comprehensive imaging based studies. Currently, the only generally used screening tool in young women is Clinical Breast Exam (CBE). However, CBE has low sensitivity, high false- positive rate and is examiner dependent. Electrical Impedance Spectroscopy (EIS) is a promising technology for fulfilling a pre-screening risk identification role as it relies on relatively inexpensive equipment that could be widely disseminated to practitioners' offices and it has demonstrated some effectiveness in detecting breast cancer regardless of age or breast density. Unfortunately, EIS technologies have demonstrated a relatively low sensitivity (~ 25 - 35%) when a high specificity (>90%) is required. Recently a new approach to EIS measurements has been developed and used quite successfully in non-medical applications. This new approach measures shifts in impedance near the resonant frequency when tissue is made a part of an RLC electric circuit. We refer to this new approach as Resonant Electrical Impedance Spectroscopy (REIS). The sensitivity of EIS near the resonant frequency is extremely high and we believe that using this approach (REIS) a much greater diagnostic performance can be achieved than was previously obtainable with EIS. In the R21 phase of this study we will build a prototype REIS device for rapidly evaluating (less than 10 minues) the breast and demonstrate feasibility for pre-screening women with the REIS device to determine who would benefit from a diagnostic imaging workup. This is not a breast cancer detection device but rather a risk stratification approach. Namely, the ultimate objective is to develop and test an approach that would segment the younger women population (< 40 years old) into two groups. One (REIS negative) that is expected to have normal risk of having breast cancer and the other (REIS positive) which identifies a group of women in which the risk of having breast cancer is substantially higher than in older women (40 - 49 years old) who are currently routinely screened. In the R33 phase a much larger patient population will be recruited and will be used to optimize the classification algorithm. Comparisons will be made with existing EIS technology. In this application we are proposing building and evaluating a device for identifying pre-menopausal women who are at increased risk for breast cancer and would thus benefit from an imaging based evaluation of the breast. This would be achieved using a low cost, safe technology that could be used during routine office visits of young women who are not screened with mammography. If successful, this proposal will have a large public health impact via increased early detection of breast cancer.
描述(由申请人提供):尽管在较早年龄损失的人年中,患乳腺癌的风险很低,但死于这种疾病的人是 40 岁以下的女性。不幸的是,乳房X光检查作为乳腺癌检测的“金标准”和公认的做法,在年轻女性中表现不佳,加上辐射风险和预期的低产量,导致建议不建议对普通人群进行年度筛查。建议这个年龄段以下。存在替代成像方式(例如 MRI、US),但是,由于多种原因,这些技术并未用于此目的。如果有一种廉价、易于使用、广泛使用的技术可以对女性进行预筛查并确定谁最有可能从更全面的基于成像的研究中受益,那么这将极大地促进年轻女性乳腺癌的检测。目前,年轻女性唯一普遍使用的筛查工具是临床乳房检查(CBE)。然而,CBE 的敏感性低、假阳性率高并且依赖于检查者。电阻抗光谱 (EIS) 是一种很有前途的技术,可用于完成预筛查风险识别作用,因为它依赖于相对便宜的设备,可以广泛分发到从业人员的办公室,并且已证明它在检测乳腺癌方面具有一定的有效性,无论年龄或乳腺癌如何密度。不幸的是,当需要高特异性 (>90%) 时,EIS 技术表现出相对较低的灵敏度 (~ 25 - 35%)。最近开发了一种新的 EIS 测量方法,并在非医疗应用中非常成功地使用。当组织成为 RLC 电路的一部分时,这种新方法可测量谐振频率附近的阻抗变化。我们将这种新方法称为共振电阻抗光谱 (REIS)。 EIS 在谐振频率附近的灵敏度非常高,我们相信使用这种方法 (REIS) 可以获得比以前使用 EIS 获得的更好的诊断性能。在本研究的 R21 阶段,我们将构建一个 REIS 设备原型,用于快速评估(不到 10 分钟)乳房,并展示使用 REIS 设备对女性进行预筛查以确定谁将从诊断成像检查中受益的可行性。这不是乳腺癌检测设备,而是一种风险分层方法。也就是说,最终目标是开发和测试一种将年轻女性群体(< 40 岁)分为两组的方法。一个(REIS 阴性)预计具有正常的乳腺癌风险,另一个(REIS 阳性)则确定一组女性患乳腺癌的风险明显高于老年女性(40 - 49 岁) )目前正在定期筛查的人。在 R33 阶段,将招募更多的患者群体并将其用于优化分类算法。将与现有的 EIS 技术进行比较。在此应用中,我们建议构建和评估一种设备,用于识别乳腺癌风险增加的绝经前女性,从而受益于基于乳房成像的评估。这将通过一种低成本、安全的技术来实现,该技术可以在未接受乳房X光检查的年轻女性的例行就诊期间使用。如果成功,该提案将通过增加乳腺癌的早期发现对公共健康产生巨大影响。
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Improving breast cancer risk stratification using resonance-frequency electrical impedance spectroscopy through fusion of multiple classifiers.
通过融合多个分类器,使用共振频率电阻抗谱改善乳腺癌风险分层。
- DOI:
- 发表时间:2011-03
- 期刊:
- 影响因子:3.8
- 作者:Lederman, Dror;Zheng, Bin;Wang, Xingwei;Wang, Xiao Hui;Gur, David
- 通讯作者:Gur, David
Detection of breast abnormalities using a prototype resonance electrical impedance spectroscopy system: a preliminary study.
使用原型共振电阻抗光谱系统检测乳房异常:初步研究。
- DOI:
- 发表时间:2008-07
- 期刊:
- 影响因子:3.8
- 作者:Zheng, Bin;Zuley, Margarita L;Sumkin, Jules H;Catullo, Victor J;Abrams, Gordon S;Rathfon, Grace Y;Chough, Denise M;Gruss, Michelle Z;Gur, David
- 通讯作者:Gur, David
A GMM-based breast cancer risk stratification using a resonance-frequency electrical impedance spectroscopy.
使用共振频率电阻抗谱进行基于 GMM 的乳腺癌风险分层。
- DOI:
- 发表时间:2011-03
- 期刊:
- 影响因子:3.8
- 作者:Lederman, Dror;Zheng, Bin;Wang, Xingwei;Sumkin, Jules H;Gur, David
- 通讯作者:Gur, David
A preliminary evaluation of multi-probe resonance-frequency electrical impedance based measurements of the breast.
基于多探头谐振频率电阻抗的乳房测量的初步评估。
- DOI:
- 发表时间:2011-02
- 期刊:
- 影响因子:4.8
- 作者:Zheng, Bin;Lederman, Dror;Sumkin, Jules H.;Zuley, Margarita L.;Gruss, Michelle Z.;Lovy, Linda S.;Gur, David
- 通讯作者:Gur, David
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