Oral Cancer Screening via Spectral Cytopathology

通过光谱细胞病理学筛查口腔癌

• 批准号: 8088196
• 负责人: MAX DIEM
• 金额: $ 16.4万
• 依托单位: NORTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8088196
• 关键词: Abbreviations; Abnormal Cell; Address; Administrative Supplement; Affect; Alcohol consumption; Algorithms; Benign; Biochemical; Biological Assay; Biological Markers; Biopsy; Boston; Cancer Detection; Cancer Etiology; Cancer Patient; Cancerous; Cells; Cellular Morphology; Cervical Cancer Screening; Cessation of life; Clinical; Clinical Trials; Collaborations; Collecting Cell; Computers; Conceptions; Coupled; Cytology; Cytology Histology; Cytopathology; DNA; Data; Data Set; Databases; Dental; Dental Hygienists; Dentists; Detection; Development; Diagnosis; Diagnostic; Diagnostic Procedure; Diagnostic tests; Discrimination; Disease; Early treatment; Epithelial; Ethnic Origin; Fixatives; Funding Mechanisms; Gender; Gene Structure; Head and Neck Cancer; Head and Neck Part; Head and neck structure; Health; Healthcare; Herpes Simplex Infections; Hodgkin Disease; Individual; Institutional Review Boards; Invaded; Knowledge; Laboratories; Lesion; Location; Malignant - descriptor; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Malignant neoplasm of nasopharynx; Malignant neoplasm of testis; Measurement; Measures; Medical center; Methodology; Methods; Mining; Molecular; Monitor; Morbidity - disease rate; Mouth Diseases; Multivariate Analysis; Nasal cavity; Neck; Neoplasm Metastasis; Nicotine; Normal Cell; Oral; Oral cavity; Paper; Pathology; Patients; Physicians; Population; Premalignant; Preparation; Prevention; Primary Neoplasm; Principal Component Analysis; Process; Proteins; Proteome; Published Comment; Publishing; Race; Reading; Recurrence; Relative (related person); Research; Sampling; School Dentistry; Screening for Oral Cancer; Screening for cancer; Screening procedure; Sensitivity and Specificity; Shapes; Signal Transduction; Staging; Structure; Students; Survival Rate; Symptoms; System; Techniques; Testing; Text; Time; Tissues; Training; Tumor Tissue; Universities; Variant; Virus Diseases; Visit; Voice; Work; base; cancer cell; cancer diagnosis; clinical application; clinically relevant; clinically significant; cost; data acquisition; high risk; improved; lymph nodes; malignant mouth neoplasm; melanoma; mortality; novel diagnostics; pre-clinical; response; sample fixation; tissue fixing; tool; tumor

DESCRIPTION (provided by applicant): This Application is submitted in response to PA-09-238 "Exfoliated Cells and Circulating DNA in Cancer Detection and Diagnosis" under the R21 funding mechanism. The work proposed in this application is aimed at developing automatic screening methods for oral and nasopharyngeal cancer, based on Spectral Cytopathology (SCP) which is a new diagnostic method based on a spectroscopic measurement of individual cells coupled to computer-based analysis. Proof-of-principle for detecting abnormal cells from the oral cavity via SCP was achieved, and identification of abnormal cells was found to be possible even before morphological changes occur in the cells. This proposal emphasizes the clinical significance of oral cancer screening by spectral methods; furthermore, it will extend the study to other parts of the head-and-neck (H&N) region, and collect datasets of sufficient size to attract other funding mechanisms to take this research to a commercial product. Oral and H&N cancer screening was selected for a target because such screening is not being carried out at this point, although cancers of the oral cavity are a major health problem, with a mean 5- year survival rate less than that of cancers which are more in the public's view, such Hodgkin's lymphoma, testicular cancer, or malignant melanoma. As in all epithelial cancers, early detection and treatment will increase the survival rate from H&N cancers, which presently are detected often after they have penetrated deeply into the surrounding tissue, or have formed metastases. SCP-based oral and H&N cancer screening can be carried out as easily as cervical cancer screening, and will reduce the complications and mortality from this disease.

描述（由申请人提供）：本申请是为了响应 R21 资助机制下的 PA-09-238“癌症检测和诊断中的脱落细胞和循环 DNA”而提交的。本申请中提出的工作旨在开发基于光谱细胞病理学（SCP）的口腔癌和鼻咽癌的自动筛查方法，这是一种基于单个细胞的光谱测量与计算机分析相结合的新诊断方法。实现了通过 SCP 检测口腔异常细胞的原理验证，并且发现甚至在细胞发生形态变化之前就可以识别异常细胞。该提案强调了光谱方法筛查口腔癌的临床意义；此外，它将将该研究扩展到头颈（H＆N）区域的其他部分，并收集足够规模的数据集以吸引其他资助机制将该研究转化为商业产品。选择口腔癌和 H&N 癌症筛查作为目标，因为目前尚未进行此类筛查，尽管口腔癌是一个主要的健康问题，其平均 5 年生存率低于其他癌症。在公众看来，比如霍奇金淋巴瘤、睾丸癌或者恶性黑色素瘤。与所有上皮癌一样，早期检测和治疗将提高 H&N 癌症的生存率，目前这些癌症通常在深入渗透到周围组织或形成转移后才被发现。基于 SCP 的口腔癌和 H&N 癌症筛查可以像宫颈癌筛查一样轻松进行，并将减少该疾病的并发症和死亡率。

项目成果

Vibrational spectroscopic changes of B-lymphocytes upon activation.

B 淋巴细胞激活后的振动光谱变化。

• DOI: 10.1002/jbio.201200136
• 发表时间: 2013
• 期刊: Journal of biophotonics
• 影响因子: 2.8
• 作者: Mazur,AntonellaI;Monahan,JenniferL;Miljkovic,Milos;Laver,Nora;Diem,Max;Bird,Benjamin
• 通讯作者: Bird,Benjamin