Children of Bipolar Parents: A High-Risk Follow-up Study

双相情感障碍父母的孩子：一项高风险随访研究

基本信息

批准号：
7885972
负责人：
DAVID A AXELSON
金额：
$ 112.49万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-08-20 至 2016-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7885972
关键词：
18 year old Accounting Adolescence Adolescent Adult Affect Affective Age Age of Onset Aggressive behavior Alcohol or Other Drugs use Amygdaloid structure Anatomy Anxiety Anxiety Disorders Asses Attention Attention deficit hyperactivity disorder Back Behavior Behavioral Biological Assay Biological Markers Biological Markers Bipolar Disorder Brain Child Child Development Childhood Circadian Rhythms Clinical Cognitive Communities Conduct Disorder Corpus striatum structure DNA DSM-IV Data Data Analyses Demographic Factors Detection Development Diagnosis Diffusion Magnetic Resonance Imaging Disease Disruptive Behavior Disorder Emotional Emotions Enrollment Environmental Risk Factor Event Exposure to Facial Expression Family Family history of Fathers Figs - dietary Functional disorder Funding Gender Genetic Genetic Polymorphism Goals Hormonal Image Imaging Techniques Impulsivity Incidence Intervention Interview Interviewer Label Lateral Life Light Longitudinal Studies Major Depressive Disorder Manic Measurement Measures Medial Mediator of activation protein Memory Mental Depression Mental disorders Mission Modeling Mood Disorders Moods Morbidity - disease rate Mothers National Institute of Mental Health Neurobiology Neurocognitive Neurocognitive Deficit Onset of illness Outcome Parents Pathogenesis Pathway interactions Pattern Performance Pharmaceutical Preparations Pharmacological Treatment Phase Phenotype Population Predisposition Prefrontal Cortex Problem behavior Process Progress Reports Protocols documentation Psychopathology Psychosocial Factor Puberty Publications Qualifying Questionnaires Recommendation Recording of previous events Recruitment Activity Regulation Relative (related person)Research Personnel Resources Risk Risk Factors Salivary Sample Size Sampling Sampling Studies Signal Transduction Sleep Specific qualifier value Stimulus Strategic Planning Study Section Substance Use Disorder Substance abuse problem Support System Symptoms Task Performances Testing Verbal Learning Youth age effect biosignature blind clinically relevant cognitive control cohort disorder control early onset emotion regulation endophenotype executive function family genetics follow-up functional disability gray matter high risk inattention information gathering instrument interest mood regulation neural circuit neuroimaging neuropsychological offspring outcome forecast prevent psychologic psychosocial relating to nervous system sex social stressor subclinical depression success suicidal behavior suicidal risk transmission process white matter young adult

项目摘要

DESCRIPTION (provided by applicant): This is a renewal of the protocol entitled "Children of Bipolar Parents: A High-Risk Follow-up Study" (NIMH #60952) also known as the Bipolar Offspring Study (BIOS). In line with the current NIMH Strategic Plan, BIOS has been investigating the additive effects of behavioral, affective, circadian/sleep, genetic, and psychosocial factors associated with the development of mood disorders in the offspring of parents with bipolar disorder (BP). Enrollment of BIOS sample was completed in July 2007 with 862 children recruited (509 from parents with BP and 353 from community control parents) and a retention rate of 87%. Interviewers, blind to parental diagnosis, assessed offspring every other year with a comprehensive battery of instruments. BIOS is beginning to elucidate a specific developmental progression to bipolarity in the offspring of parents with BP and as to date, offspring of parents with BP are at significantly higher risk to develop BP-I (OR: 19.5) or subsyndromal BP (OR: 31.2). Since most of the sample will enter the age of highest risk to develop BP and other mood disorders during the next funding period, we are proposing to continue to study this sample for 5 more years. For a subset of 200 children of parents with BP and control parents, we propose to measure neurocognitive functioning and activity in, and functional and anatomic connectivity between, neural regions implicated in the pathogenesis of BP, and obtain more precise measurements of puberty using salivary hormonal levels. We hypothesize that, relative to offspring of control parents, offspring of parents with BP will develop over follow-up: 1) higher rates of mood disorders and psychopathology (e.g., mood lability, disrupted sleep) and 2) deficits in neurocognitive functioning and neurocircuitry associated with emotion processing and regulation. In addition, in offspring of parents with BP, onset of BP or any mood disorder will be predicted by the combined effects of development, demographic factors, other psychiatric disorders, dimensional behavioral and mood phenotypes, family environmental factors, and their interactions. Within the subset of offspring of parents with BP who will have neurocognitive and neuroimaging data, onset of BP or any mood disorder will be predicted by abnormal neurocognitive functioning and activity and connectivity in neural circuitry for emotion processing and regulation, that in turn will be associated with sleep and circadian factors, puberty, and clinical and demographic risk factors identified above. Findings from this large study will help identify the initial symptoms and neurobiomarkers related to increased risk of BP in youth. Such findings will facilitate prompt diagnosis and interventions, thus preventing, or at least ameliorating, the negative effects of this severe illness in youth. PUBLIC HEALTH RELEVANCE: Bipolar disorder is a severe illness associated with considerable negative consequences for the normal development of the child and increased risk for suicide and substance abuse. However, little is known about the initial symptoms and the progression of this illness from childhood and adolescence to adulthood. The findings from this large study will help to identify the initial symptoms and some brain biological markers related to the increased risk to develop bipolar in youth. Such findings will advance the field so that prompt diagnosis and interventions are made, thus preventing or at least ameliorating the negative effects of this severe illness in youth.

描述（由申请人提供）：这是“双极父母的孩子：高风险后续研究”（NIMH＃60952）的续签，也称为双极后代研究（BIOS）。与当前的NIMH战略计划一致，BIOS一直在研究行为，情感，昼夜节律/睡眠，遗传和社会心理因素的累加作用，与双相情感障碍父母（BP）后代的发展中的情绪障碍有关。 BIOS样本的入学率在2007年7月完成，招募了862名儿童（来自BP的父母509名，来自社区对照父母的353名儿童），保留率为87％。对父母诊断的面试官，每隔一年就用一系列的乐器评估后代。 BIOS开始阐明BP父母后代的特定发育发展，而迄今为止，BP父母的后代出现了发展BP-I（OR：19.5）或亚与同步性BP（OR：：31.2）的风险明显更高。由于大多数样本将在下一个资金期间进入患有BP和其他情绪障碍的最高风险年龄，因此我们建议继续研究此样本5年。对于200个患有BP和控制父母的父母的子集的子集，我们建议在与BP发病机理有关的神经认知功能和活性，功能和解剖连通性中，并使用唾液激素水平获得青春期的更精确测量。我们假设，相对于控制父母的后代，BP父母的后代将在随访中发展：1）更高的情绪障碍和心理病理学率（例如，情绪不稳定，睡眠中断）和2）神经认知功能和神经通道的缺陷与情绪处理和调节有关。此外，在BP父母的后代，BP或任何情绪障碍的发作将由发育，人口统计学因素，其他精神疾病，维度行为和情绪表型，家庭环境因素及其相互作用的综合作用预测。 Within the subset of offspring of parents with BP who will have neurocognitive and neuroimaging data, onset of BP or any mood disorder will be predicted by abnormal neurocognitive functioning and activity and connectivity in neural circuitry for emotion processing and regulation, that in turn will be associated with sleep and circadian factors, puberty, and clinical and demographic risk factors identified above.这项大型研究的结果将有助于确定与青年人BP风险增加有关的最初症状和神经虫标志物。这些发现将促进及时的诊断和干预措施，从而防止或至少改善这种严重疾病对青年人的负面影响。公共卫生相关性：双相情感障碍是一种严重疾病，对儿童的正常发育造成了严重的负面影响，并增加了自杀和滥用药物的风险。但是，对从童年和青春期到成年的最初症状以及这种疾病的进展知之甚少。这项大型研究的发现将有助于确定最初的症状和一些大脑生物学标志物，与年轻人发展双相情感障碍有关的风险增加有关。这样的发现将推进该领域，以便进行迅速的诊断和干预措施，从而防止或至少改善这种严重疾病对青年人的负面影响。