IN VIVO SAFETY AND EFFICACY OF CAP FILM AND MICROBICIDE COMBINATIONS

帽膜和杀菌剂组合的体内安全性和功效

• 批准号: 8172991
• 负责人: CECILIA C CHENG-MAYER
• 金额: $ 6.18万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172991
• 关键词: Adult; Animals; Attenuated; Computer Retrieval of Information on Scientific Projects Database; Dose; Female; Film; Funding; Gel; Genes; Grant; HIV-1; Hour; Institution; Macaca; Methods; RNA-Directed DNA Polymerase; Research; Research Personnel; Resources; Safety; Source; United States National Institutes of Health; Vagina; Viral; Virus; in vivo; microbicide; research study; simian human immunodeficiency virus; transmission process

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: We proposed to establish the efficacy MIV-160 alone against simian human immunodeficiency virus containing the reverse transcriptase gene of HIV-1 (SHIV-RT). Six animals were used for this experiment. Methods: Three (3) ml of MIV-160, 500¿M/ml in hydroxymethycellulose (HEC) gel was applied vaginal into 6 adult Indian female macaques. Half -hour post gel application, each animal was challenged vaginally with 1 ml high dose 10000 TCID50 of SHIV-RT. Again, 2 ml each of MIV-160 was applied vaginally in the respective animals. 30 minutes post SHIV-RT challenge. Results/Discussion: All animals were infected. MIV-160 failed to impede transmission of the impute virus. All animals had high viral set points which indicate that MIV-160 did not alter nor attenuate SHIV-RT.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中央赠款提供的资源 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，在列出的机构中可能会被压制 对于中心，这不一定是调查员的工厂。 背景：我们对单独的MIV-160进行了针对HIV-1的反向旋转剂的免疫缺陷（SHIV-RT）。 » ML在凝胶型（HEC）中，将阴道涂在6个成年型猕猴中。在各自的动物中。 结果/讨论：MIV-160未能阻止含量病毒的传播。