PIWI-interacting RNA-guided somatic gene regulation in cell homeostasis and differentiation

PIWI相互作用RNA引导的体细胞基因调控细胞稳态和分化

• 批准号: RGPIN-2022-03780
• 负责人: Kakumani, PavanKumar
• 金额: $ 2.26万
• 依托单位: Memorial University of Newfoundland
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=744083
• 关键词: PIWI; interacting; RNA; guided; somatic; PIWI; interacting; RNA; guided; somatic

In the late nineties, researchers uncovered a new cellular pathway in animals which is triggered by duplex RNA molecules and controls the flow of genetic information. This breakthrough discovery called RNA interference (RNAi) was acknowledged by the Nobel Committee in 2006 for its potential in the development of novel RNA-based technologies based on small non-coding RNAs (sncRNAs) that will be extremely useful for biological research and industrial application. My research group will investigate the role of sncRNA named PIWI-interacting RNA (piRNA) in gene regulation using human and mouse cell lines, including those with regenerative capacity to understand their complex mechanisms defining cellular characteristics and function. I believe that this innovative research program will contribute to unveil the importance of piRNAs in determining cellular identity and support the use of piRNAs as molecular tools in research laboratories and industries focused on life science and biomedicine.

在90年代后期，研究人员发现了动物中的一种新的细胞途径，该途径是由双链RNA分子触发的，并控制了遗传信息的流动。诺贝尔委员会在2006年因其在基于小型非编码RNA（SNCRNA）的新型基于RNA的技术方面的潜力而被诺贝尔委员会在2006年被诺贝尔委员会承认这一突破性发现，这对生物学研究和工业应用非常有用。 我的研究小组将使用人和小鼠细胞系调查名为Piwi相互作用RNA（PIRNA）在基因调节中的作用，包括具有重生能力的人，可以理解其复杂机制，以定义细胞特征和功能。我认为，这项创新的研究计划将有助于揭示PIRNA在确定细胞身份的重要性，并支持将PIRNA用作研究实验室和行业的分子工具的使用，这些工​​具专注于生命科学和生物医学。