Motion Artifact Reduced SDOCT of the Anterior Segment

运动伪影减少了眼前节的 SDOCT

基本信息

批准号：
8007353
负责人：
JOSEPH A IZATT
金额：
$ 18.72万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-01-01 至 2012-12-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Accurate quantitative imaging of the cornea is critical for predictable outcomes in corneal based surgical interventions. While long the standard, reflection based corneal topography to assess corneal curvature and refractive power is insufficient in an era when surgical manipulation of the corneal shape is routine and undermines the basis of reflection topography. Laser refractive surgery is one particular corneal intervention that has revealed current inadequacies in measuring the cornea. Over 7 million people in the United States have had some form of laser refractive surgery to reduce their dependence on corrective eye wear. The corneal reshaping that occurs from laser refractive surgery results in excellent visual results for the patient but renders current technologies incapable of accurately measuring the power of the reshaped cornea. Accurate measurement of corneal power is critical in applications such as the prediction of intraocular lens power needed after cataract surgery, an event which this group of patients will invariably encounter as they age into late adulthood. Our proposed development of a motion corrected high-speed spectral domain optical coherence tomography (SDOCT) based device which can directly map corneal surfaces at micron resolution and then accurately convert this data to keratometric values will greatly aid clinical applications dependent on this value. The primary innovations will be the development of novel hardware and software methods to account for involuntary patient motion and for refraction of OCT light within the cornea. A clinical comparison will then be made in patients undergoing laser refractive surgery to compare the measurements made by SDOCT versus existing clinical instrumentation for the measurement of corneal power. PUBLIC HEALTH RELEVANCE: We propose to develop an improved ocular anterior segment imaging system using spectral domain optical coherence tomography. If successful, this project could support widespread adoption of SDOCT as the preferred, single-platform anterior segment imaging device in eye care delivery.

描述（由申请人提供）：角膜的准确定量成像对于基于角膜的手术干预的可预测结果至关重要。尽管长期以来，用于评估角膜曲率和屈光力的基于反射的角膜地形图的标准是不够的，但在角膜形状的手术操作已成为常规并且破坏了反射地形图的基础的时代，这是不够的。激光屈光手术是一种特殊的角膜干预措施，它揭示了当前角膜测量的不足之处。在美国，超过 700 万人接受了某种形式的激光屈光手术，以减少对矫正眼镜的依赖。激光屈光手术进行的角膜重塑为患者带来了良好的视觉效果，但目前的技术无法准确测量重塑角膜的屈光度。准确测量角膜屈光力对于预测白内障手术后所需的人工晶状体屈光力等应用至关重要，白内障手术后这组患者不可避免地会遇到这种情况。我们提议开发一种基于运动校正的高速谱域光学相干断层扫描（SDOCT）的设备，该设备可以以微米分辨率直接映射角膜表面，然后将该数据准确地转换为角膜曲率值，这将极大地帮助依赖于该值的临床应用。主要创新将是开发新颖的硬件和软件方法，以解决患者不自主运动和角膜内 OCT 光的折射问题。然后将对接受激光屈光手术的患者进行临床比较，以将 SDOCT 的测量结果与现有的角膜屈光力测量临床仪器进行比较。公共健康相关性：我们建议使用谱域光学相干断层扫描开发一种改进的眼前节成像系统。如果成功，该项目可以支持广泛采用 SDOCT 作为眼科护理中首选的单平台眼前节成像设备。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Distributed scanning volumetric SDOCT for motion corrected corneal biometry.

DOI：
10.1364/boe.3.002050
发表时间：
2012-09-01
期刊：
Biomedical optics express
影响因子：
3.4
作者：
McNabb RP;Larocca F;Farsiu S;Kuo AN;Izatt JA
通讯作者：
Izatt JA

Corneal biometry from volumetric SDOCT and comparison with existing clinical modalities.

DOI：
10.1364/boe.3.001279
发表时间：
2012-06-01
期刊：
Biomedical optics express
影响因子：
3.4
作者：
Kuo AN;McNabb RP;Zhao M;Larocca F;Stinnett SS;Farsiu S;Izatt JA
通讯作者：
Izatt JA

Optical coherence tomography accurately measures corneal power change from laser refractive surgery.

DOI：
10.1016/j.ophtha.2014.10.003
发表时间：
2015-04
期刊：
OPHTHALMOLOGY
影响因子：
13.7
作者：
McNabb, Ryan P.;Farsiu, Sina;Stinnett, Sandra S.;Izatt, Joseph A.;Kuo, Anthony N.
通讯作者：
Kuo, Anthony N.

Robust automatic segmentation of corneal layer boundaries in SDOCT images using graph theory and dynamic programming.