MRI Methods for Guiding Focused Ultrasound in the Brain

引导大脑聚焦超声的 MRI 方法

• 批准号: 8051786
• 负责人: Kim Butts-Pauly
• 金额: $ 19.22万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8051786
• 关键词: Ablation; Acoustics; Algorithms; Blood - brain barrier anatomy; Brain; Deposition; Development; Dose; Elements; Feedback; Focused Ultrasound Therapy; Gel; Goals; Head; Heating; Image; Imagery; Location; Magnetic Resonance; Magnetic Resonance Imaging; Measures; Methods; Modeling; Neurologic; Phase; Physiologic pulse; Positioning Attribute; Procedures; Public Health; Puncture procedure; Radiation; Resolution; Safety; Scanning; Simulate; Skin; Sonication; Structure; Surgical incisions; System; Techniques; Temperature; Testing; Thick; Time; Tissues; Ultrasonic Therapy; Ultrasonography; X-Ray Computed Tomography; acoustic imaging; base; cancer therapy; cold temperature; cost; cranium; imaging modality; improved; innovation; neurosurgery; next generation; public health relevance; tumor; visual feedback

DESCRIPTION (provided by applicant): The goal of this project is to develop advanced magnetic resonance (MR) imaging methods for guiding high intensity focused ultrasound (FUS) in applications in the head. FUS is a promising technique for the next generation of non-invasive therapy systems. One important feature of FUS lies in its ability to apply ultrasound from outside the body, without any skin puncture or incision. The ultrasound energy can be focused to a point within the brain, with minimal heating of the intervening tissues. The significance of this project is that it would develop imaging methods that would improve the safety and efficacy of this exciting new treatment method for neurological applications. The approach of this project is to develop MR imaging methods for both improving the quality of the focus and for visualizing the location of the focus, based on the acoustic radiation force. Imaging of the acoustic radiation force with MRI is called MR-ARFI. Our specific aims are to 1) improved MR ARFI pulse sequences, 2) develop autofocusing algorithms, and 3) develop algorithms to localize the ultrasound focus. The innovation of the project is the development of an automated way to improve the ultrasound beam focus in the brain without the cost, inconvenience, and the radiation dose of a presurgical CT scan. In addition, we will improve the visualization of the focus location, without unnecessary heat deposition in sensitive structures. PUBLIC HEALTH RELEVANCE: Focused ultrasound is a promising technique for the next generation of non-invasive cancer therapy systems. The relevance of this project to public health is that it would provide improved methods for guiding focused ultrasound treatments in the brain.

描述（由申请人提供）：该项目的目的是开发高级磁共振（MR）成像方法，用于指导头部应用中的高强度聚焦超声（FUS）。 FUS是下一代非侵入性治疗系统的一种有前途的技术。 FUS的一个重要特征在于它能够从体外施加超声波，而没有任何皮肤穿刺或切口。超声能量可以聚焦到大脑内的一个点，而中间组织的加热最少。该项目的意义在于，它将开发成像方法，以提高这种令人兴奋的神经系统应用新治疗方法的安全性和功效。该项目的方法是开发MR成像方法，以提高焦点的质量和基于声学辐射力的焦点位置的可视化位置。用MRI进行声学辐射力的成像称为MR-ARFI。我们的具体目的是1）改善MR ARFI脉冲序列，2）开发自动关注算法和3）开发算法以定位超声焦点。该项目的创新是开发一种自动化方法，以提高大脑的超声梁聚焦，而无需成本，不便和辐射剂量的前术CT扫描的辐射剂量。此外，我们将改善聚焦位置的可视化，而不会在敏感结构中不必要的热量沉积。 公共卫生相关性：专注于超声是下一代非侵入性癌症治疗系统的有前途的技术。该项目与公共卫生的相关性是，它将为指导大脑中的专注超声治疗提供改进的方法。