VisualSonics Vevo 2100 Small Animal Ultrasound Imaging System and Accessories

VisualSonics Vevo 2100 小动物超声成像系统和配件

基本信息

批准号：
7792714
负责人：
John A Hossack
金额：
$ 48.25万
依托单位：
UNIVERSITY OF VIRGINIA
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-12-10 至 2010-12-09
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7792714
关键词：
Anatomy Animal Experimentation Animals Area Basic Science Behavior Blood Flow Velocity Blood flow Cardiac Cardiovascular system Clinical Collaborations Color Communities Computer software Defect Diabetes Mellitus Elements Fostering Frequencies Functional Imaging Funding Funding Applicant Hour Image Individual Institutes Letters Malignant Neoplasms Methods Metric Microbubbles Minor Modality Molecular Target Mus Myocardium National Heart, Lung, and Blood Institute National Institute of Allergy and Infectious Disease National Institute of Biomedical Imaging and Bioengineering National Institute of Diabetes and Digestive and Kidney Diseases Nephrology Performance Perfusion Phase Physiologic pulse Research Research Personnel Resolution Scanning System Time Tissues Transducers Ultrasonography United States National Institutes of Health Universities Virginia base cost improved instrument instrumentation molecular imaging public health relevance soft tissue

项目摘要

DESCRIPTION (provided by applicant): Funds are requested to purchase a VisualSonics Vevo2100 phased array small animal ultrasound imaging system - including transducers appropriate for cardiovascular, cancer, nephrology and diabetes research. High resolution ultrasound is the preferred modality for obtaining noninvasive anatomic, functional and molecular imaging of small animals widely used in NIH funded basic research. High resolution ultrasound provides excellent spatial resolution (35 <m x 60 <m at the highest proposed frequency), excellent soft tissue contrast and very high frame rates (up to 1000 frames per second). The newly released Vevo2100 scanner provides substantially improved performance with respect to the earlier mechanically swept single element Vevo770 scanner. Thus, the new Vevo2100 provides unique performance in terms of ability to resolve fine spatial detail (i.e. anatomic imaging), image and quantify blood flow (i.e. functional imaging) and detect molecular targeted microbubbes (i.e. molecular imaging - part of the NIH Roadmap Priorities). The Vevo2100 phased array scanner provides imaging at up to 70 MHz whereas clinical phased array scanners are limited to the 15- 18MHz range. The Vevo2100 that we propose to purchase has Color Doppler for visualizing blood flow dynamics, Power Doppler for sensitive imaging and quantification of perfusion, Pulsed-Wave Doppler for quantification of blood flow velocity. The scanner also possesses tissue tracking software to enable assessment and quantification of cardiac contractile defects. The new scanner will accelerate the pace of our research by simultaneously improving the technical quality of our scans while achieving comprehensive scans of individual animals in a few minutes as opposed to approximately one hour using existing instrumentation. The improved acquisition rate will enable more meaningful resolution of 3D displacements of the mouse myocardium. The significantly improved contrast (microbubble) imaging capability of the Vevo2100 will enable vastly superior assessment of ischemic tissue. We have obtained a letter of support from the VisualSonics founder and Chief Scientific Officer Stuart Foster indicating a high level of technical collaboration that will allow us to more fully exploit the technical capabilities of this instrument. Specifically, we continue to develop new metrics for describing cardiac function and we plan to explore the relatively untouched area of microbubble behavior under ultrasound excitation at >30MHz. This collaboration may require access to minor changes in the software to suit our research and in return some of our technical contributions may be later exploited on the VisualSonics platform so as to more widely positive impact the mouse imaging community. Eight University of Virginia-based Major Users will share access to the instrument. An additional six Minor Users will share remaining time. These users have funding from the following NIH component institutes: NIBIB, NHLBI, NCI, NIDDK, NIAID. PUBLIC HEALTH RELEVANCE: University of Virginia researchers request funds to purchase a VisualSonics Vevo 2100 small animal ultrasound imaging system with transducers appropriate for cardiovascular, cancer, nephrology and diabetes research. High resolution ultrasound is the preferred method for obtaining noninvasive images of the interior of small animals widely used in various fields of research. In this way, the instrument proposed will accelerate the pace of research, reduce the cost of conducting research (displacing more expensive methods) and reduce the total usage of research animals (by replacing sacrifice-based study with time-serial study).

描述（由申请人提供）：申请资金购买 VisualSonics Vevo2100 相控阵小动物超声成像系统 - 包括适用于心血管、癌症、肾病和糖尿病研究的传感器。高分辨率超声是获得小动物无创解剖、功能和分子成像的首选方式，广泛用于 NIH 资助的基础研究。高分辨率超声提供出色的空间分辨率（在最高建议频率下为 35 <m x 60 <m）、出色的软组织对比度和非常高的帧速率（高达每秒 1000 帧）。与早期的机械扫描单晶 Vevo770 扫描仪相比，新发布的 Vevo2100 扫描仪的性能显着提高。因此，新的 Vevo2100 在解析精细空间细节（即解剖成像）、成像和量化血流（即功能成像）以及检测分子靶向微泡（即分子成像 - NIH 路线图优先事项的一部分）方面提供了独特的性能。。 Vevo2100 相控阵扫描仪提供高达 70 MHz 的成像频率，而临床相控阵扫描仪仅限于 15-18 MHz 范围。我们建议购买的 Vevo2100 具有用于可视化血流动力学的彩色多普勒、用于敏感成像和灌注量化的能量多普勒、用于量化血流速度的脉冲波多普勒。该扫描仪还拥有组织跟踪软件，可以评估和量化心脏收缩缺陷。新的扫描仪将加快我们的研究步伐，同时提高扫描的技术质量，同时在几分钟内实现对个体动物的全面扫描，而使用现有仪器大约需要一个小时。采集速率的提高将使小鼠心肌的 3D 位移得到更有意义的分辨率。 Vevo2100 显着改进的对比度（微泡）成像能力将使缺血组织的评估更加出色。我们已获得 VisualSonics 创始人兼首席科学官 Stuart Foster 的一封支持信，表明高水平的技术合作将使我们能够更充分地利用该仪器的技术能力。具体来说，我们继续开发描述心脏功能的新指标，并计划探索在 >30MHz 的超声激励下相对未触及的微泡行为区域。这种合作可能需要对软件进行微小的更改以适应我们的研究，作为回报，我们的一些技术贡献可能会在 VisualSonics 平台上得到利用，从而对鼠标成像社区产生更广泛的积极影响。弗吉尼亚大学的八个主要用户将共享该仪器的访问权限。另外六名未成年用户将共享剩余时间。这些用户获得以下 NIH 组成机构的资助：NIBIB、NHLBI、NCI、NIDDK、NIAID。公共健康相关性：弗吉尼亚大学研究人员请求资金购买 VisualSonics Vevo 2100 小动物超声成像系统，其传感器适用于心血管、癌症、肾病和糖尿病研究。高分辨率超声是获取小动物内部无创图像的首选方法，广泛应用于各个研究领域。这样，所提出的工具将加快研究步伐，降低研究成本（取代更昂贵的方法）并减少研究动物的总使用量（通过用时间序列研究代替基于牺牲的研究）。