Stereology System (Stereologer 2.0)

体视系统（Stereologer 2.0）

基本信息

批准号：
7795381
负责人：
David M. Yurek
金额：
$ 10.61万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-08-01 至 2011-07-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Stereology provides an important contribution to the advancement in biomedical research by improving the consistency and dependability of quantitative analytical results produced in the laboratory and reported in scientific publications. Most scientific journals are now requiring authors to only report quantitative data from morphological analyses that are obtained using stereological methods. However, the cost of setting up a stereology system in individual laboratories is usually cost-prohibitive. Our broad long-term objective is to provide a shared stereology system that will advance the research goals of four highly productive investigators at the University of Kentucky with a shared interest in examining changes in brain morphology in physiological and pathophysiological processes of the brain and spinal cord. This instrument will be used to detect changes in nerve cells, brain structures, or spinal cord structures and allow us to quantify these changes using universally accept stereological methods from samples derived from cellular clinical and/or preclinical sources and to do so with unprecedented resolution, precision and sensitivity. Other instruments of different configurations potentially available for some of these analyses are heavily used for other purposes. Consequently, these investigators are forced to use indirect or inadequate methodologies to accomplish their research goals or to use appropriate instrumentation on a collaborative basis with investigators at other institutions. Acquisition of this instrument would allow this group of investigators to complete their current and future research projects far more efficiently to generate optimal research outcomes.

描述（由申请人提供）：立体论通过提高实验室中产生的定量分析结果并在科学出版物中报告的定量分析结果的一致性和可靠性为生物医学研究的进步提供了重要贡献。现在，大多数科学期刊都要求作者仅报告使用立体方法获得的形态分析中的定量数据。但是，在单个实验室中建立立体系统的成本通常是成本良好的。我们广泛的长期目标是提供一个共同的立体学系统，该系统将促进肯塔基大学四名高产研究人员的研究目标，并共同兴趣研究大脑和脊髓的生理和病理生理过程中脑形态的变化。该仪器将用于检测神经细胞，脑结构或脊髓结构的变化，并允许我们使用普遍接受来自细胞临床和/或临床前来源的样品的立体方法来量化这些变化，并以前所未有的分辨率，源精度和灵敏度。其他可能可用于这些分析的不同配置的工具大量用于其他目的。因此，这些调查人员被迫使用间接或不足的方法来实现其研究目标或与其他机构的调查人员合作使用适当的仪器。获取该工具将使该研究人员能够更有效地完成其当前和未来的研究项目，以产生最佳的研究成果。