User-Friendly System Dynamics Analysis Tools for Translational Mind-Body Research

用于转化身心研究的用户友好的系统动力学分析工具

• 批准号: 7919003
• 负责人: YANHUI LIU
• 金额: $ 29.76万
• 依托单位: DYNADX CORPORATION
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7919003
• 关键词: Acupuncture procedure; Address; Adoption; Aging; Algorithms; Area; Arts; Behavior; Biological Markers; Businesses; Cardiology; Cardiovascular system; Characteristics; Clinical; Clinical Medicine; Clinical Research; Cognition; Collaborations; Collection; Communities; Complementary and alternative medicine; Complex; Computer Systems Development; Computer software; Computer-Aided Design; Computers; Coupling; Data; Databases; Disease; Disease Progression; Elderly; Environment; Equilibrium; Evaluation; Focus Groups; Gait; Genomics; Goals; Health; Health Services Research; Heart Rate; Heart failure; Individual; Institutes; Intervention; Investigation; Knowledge; Laboratories; Legal patent; Lower Extremity; Mathematics; Measurement; Measures; Medical; Medicine; Meridians; Methods; Mind-Body Intervention; Mind-Body Method; Modeling; Molecular Biology; Monitor; Nature; Nonlinear Dynamics; Outcome; Output; Patients; Peripheral Nervous System Diseases; Phase; Physiological; Physiological Processes; Physiology; Posture; Process; Property; Research; Research Methodology; Research Personnel; Science; Signal Transduction; Small Business Innovation Research Grant; Software Engineering; Software Tools; Structure; Syncope; System; Systems Analysis; Tai Ji; Technical Expertise; Techniques; Testing; Time; Training; Translational Research; United States National Aeronautics and Space Administration; Validation; Visual; Woman; Work; analytical method; base; body system; body-mind; cardiovascular risk factor; computer program; computerized data processing; design; electric impedance; falls; graphical user interface; innovation; kinematics; medical schools; member; neurophysiology; novel; pressure; product development; programs; public health relevance; respiratory; response; technology development; tool; usability; user friendly software; user-friendly

DESCRIPTION (provided by applicant): Biomarkers that capture dynamical system processes may be especially valuable and informative in the investigation of complementary and alternative medicine (CAM) therapies, particularly, multi-component mind-body interventions, that simultaneously target several physiological systems. The overall goal of this Phase I SBIR application is to develop a user-friendly software platform that will enable the quantification of system dynamics as well as nonlinear interactions among multiple organ systems that will be particularly suited for the study of complex CAM interventions. To this end, the proposed project assembles a cross-disciplinary team with expertise bridging CAM research, complex system analysis, physiology, and software engineering. The proposed project will focus on the following two specific aims: 1) to develop a user-friendly software platform containing a toolbox of system dynamics analyses with applications suitable for mind-body and CAM therapies. 2) To determine the usability and reliability of the software platform to analyze physiological data from investigations of CAM interventions. The long-term goal of this project is to build an innovative analysis platform that is robust, powerful and easy to use. This new analysis environment will enable CAM and mind-body researchers to apply state-of-the-art quantitative tools for system level dynamical analysis. These new analysis tools will provide objective measurements that are particularly useful for CAM therapies, and thus accelerate translational CAM research. PUBLIC HEALTH RELEVANCE: Complementary and alternative medicine (CAM) and mind-body research often deal with the most complex interventions that are better understood from a system perspective. However, CAM researchers lack necessary analysis tools that can provide objective, quantitative measurements about the system as a whole. We propose to develop a new class of computer tools to provide user-friendly and powerful methods to monitor and evaluate the efficacy of CAM interventions.

描述（由申请人提供）：捕获动态系统过程的生物标志物在补充和替代医学（CAM）疗法的研究中可能特别有价值且信息丰富，特别是同时针对多个生理系统的多成分身心干预措施。第一阶段 SBIR 应用的总体目标是开发一个用户友好的软件平台，该平台将能够量化系统动力学以及多个器官系统之间的非线性相互作用，特别适合复杂 CAM 干预的研究。为此，拟议项目组建了一个跨学科团队，其专业知识涵盖 CAM 研究、复杂系统分析、生理学和软件工程。拟议项目将重点关注以下两个具体目标：1）开发一个用户友好的软件平台，其中包含系统动力学分析工具箱以及适合身心和 CAM 疗法的应用程序。 2) 确定软件平台分析 CAM 干预研究的生理数据的可用性和可靠性。该项目的长期目标是建立一个强大、强大且易于使用的创新分析平台。这个新的分析环境将使 CAM 和身心研究人员能够应用最先进的定量工具进行系统级动态分析。这些新的分析工具将提供对 CAM 疗法特别有用的客观测量，从而加速转化 CAM 研究。 公共卫生相关性：补充和替代医学 (CAM) 以及身心研究通常涉及最复杂的干预措施，从系统角度可以更好地理解这些干预措施。然而，CAM 研究人员缺乏必要的分析工具，无法对整个系统提供客观、定量的测量。我们建议开发一类新型计算机工具，以提供用户友好且强大的方法来监测和评估 CAM 干预措施的效果。