Photonic Magnetometer-based Biomagnetic Imaging System

基于光子磁力计的生物磁成像系统

基本信息

批准号：
7908442
负责人：
John Matthews
金额：
$ 10万
依托单位：
PHYSICAL OPTICS CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-08-15 至 2011-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7908442
关键词：
Abdomen Address Algorithms Anterior Arrhythmia Back Body Surface Brain Cardiac Catheters Cause of Death Chest Claustrophobias Clinical Computer software Custom Data Data Analyses Data Display Detection Developed Countries Development Devices Diagnosis Diagnostic Disease Drops Electrocardiogram Electrodes Electronics Environment Evaluation Exercise Eye Feedback Fetal Heart Fiber Optics Goals Government Heart Heart Diseases Helium Hospitals Housing Human body Image Imaging Device Intestines Laboratories Laboratory Research Lead Left Length Life Liquid substance Liver Lung Magnetic Resonance Imaging Magnetism Magnetoencephalography Measurement Methods Monitor Muscle Myocardial Ischemia Nitrogen Noise Operating System Optics Ownership Patients Performance Persons Phase Physical environment Positioning Attribute Price Process Reliance Research Resolution Risk Side Signal Transduction Skin Small Intestines Solutions Source Spinal Cord Stomach Surface System Techniques Technology Temperature Testing Time base bioimaging clinical application clinical practice cost cryogenics data acquisition design graphical user interface heart function heart imaging imaging modality improved innovation magnetic field manufacturing process meetings novel operation photonics point of care prototype public health relevance response sensor superconducting quantum interference device tool user-friendly

项目摘要

DESCRIPTION (provided by applicant): With the exception of MRI, and to a certain extent MEG, biomagnetic imaging systems have been limited to use as laboratory research tools, due to the high cost and demands imposed by cryogenics and magnetic shielding. Nevertheless, biomagnetic imaging tools have demonstrated their potential for diagnosis in clinically important problems. For example, magnetocardiography (MCG) systems can be used to: (a) assess risk of life- threatening arrhythmias; (b) detect and characterize ischemic heart disease, (c) noninvasively localize cardiac activation, such as arrhythmia-causing regions, a pacing catheter and cardiac evoked field, or ischemic currents, and (d) study fetal heart function. To address the need for a noncryogenic multichannel magnetic imaging system capable of operating in an unshielded clinical environment, Physical Optics Corporation (POC) proposes to develop a Photonic Magnetometer-based Biomagnetic Imaging (PMBI) system. The key innovation is a high-performance photonic magnetometer (PM) that forms the building block of an imaging sensor array (ISA). The ISA consists of an array of hundreds of PMs, embedded in a vest that wraps around the patient's abdomen, enabling imaging of the back and side of the chest, as well as the front, which can significantly improve the detection and localization of abnormal cardiac function. In addition, the use of room- temperature sensors eliminates the need for costly, bulky cryogenics, enabling a more versatile and commercially viable imaging system. Eliminating 15 to 20 mm of thermal insulation that normally separates cryogenic sensors from the body surface improves the signal-to-noise ratio by a factor of up to 10. Noise cancellation algorithms, combined with high-order gradiometry, allow the PMBI system to operate in an unshielded environment, eliminating the need for magnetically shielded rooms that form a significant fraction of the cost of ownership ($1-2M) of current commercial systems. The cost of the PMBI system (~$10k) will be several orders of magnitude lower, enabling widespread use in clinical and point-of-care applications. Phase I will culminate in a demonstration of a proof-of-concept prototype of the PMBI system in laboratory testing. The Phase I limited-performance breadboard prototype will be assembled from readily available, low-cost components. Feasibility will be demonstrated through experimental verification of predicted prototype performance, and a path will be outlined for development of a custom-built, fully functional Phase II prototype that meets targeted performance goals for the final PMBI system. Processes for manufacturing and commercializing PMBI will be developed and tested in Phase II. PUBLIC HEALTH RELEVANCE: In many developed nations, cardiac disease is the leading cause of death. Magnetocardiography (MCG) is a safe, noninvasive, passive method for imaging the magnetic fields generated by the heart, that have been demonstrated to be accurate risk indicators for cardiac disorders such as ischemic heart disease. Unfortunately, MCG systems are almost completely absent from clinical practice due to the million-dollar price tag imposed by cryogenic cooling and magnetic shielding requirements. Physical Optics Corporation proposes to develop a low-cost, noncryogenic biomagnetic imaging system suitable for unshielded clinical and point-of- care applications.

描述（由申请人提供）：除了 MRI 以及一定程度上的 MEG 之外，由于低温和磁屏蔽带来的高成本和要求，生物磁成像系统仅限于用作实验室研究工具。尽管如此，生物磁成像工具已经证明了其诊断临床重要问题的潜力。例如，心磁图（MCG）系统可用于：（a）评估危及生命的心律失常的风险； (b) 检测和表征缺血性心脏病，(c) 无创定位心脏激活，例如心律失常引起区域、起搏导管和心脏诱发场或缺血性电流，以及 (d) 研究胎儿心脏功能。为了满足能够在非屏蔽临床环境中运行的非低温多通道磁成像系统的需求，物理光学公司 (POC) 提议开发基于光子磁力计的生物磁成像 (PMBI) 系统。关键的创新是高性能光子磁力计 (PM)，它构成了成像传感器阵列 (ISA) 的构建模块。 ISA 由数百个 PM 组成，嵌入包裹在患者腹部的背心中，能够对胸部的背面和侧面以及正面进行成像，这可以显着提高异常心脏的检测和定位。功能。此外，室温传感器的使用消除了对昂贵、笨重的低温设备的需求，从而实现了更通用且商业上可行的成像系统。消除了通常将低温传感器与身体表面分隔开的 15 至 20 毫米的隔热层，将信噪比提高了 10 倍。噪声消除算法与高阶梯度测量相结合，使 PMBI 系统能够运行在非屏蔽环境中，无需磁屏蔽室，而磁屏蔽室占当前商业系统拥有成本（1-200 万美元）的很大一部分。 PMBI 系统的成本（约 1 万美元）将降低几个数量级，从而能够在临床和护理点应用中广泛使用。第一阶段的最终阶段将在实验室测试中演示 PMBI 系统的概念验证原型。第一阶段的有限性能面包板原型将由现成的低成本组件组装而成。将通过对预测的原型性能进行实验验证来证明可行性，并将概述开发定制的、功能齐全的第二阶段原型的路径，以满足最终 PMBI 系统的目标性能目标。 PMBI 的制造和商业化流程将在第二阶段进行开发和测试。公共卫生相关性：在许多发达国家，心脏病是导致死亡的主要原因。心磁图 (MCG) 是一种安全、无创、被动的方法，用于对心脏产生的磁场进行成像，已被证明是缺血性心脏病等心脏疾病的准确风险指标。不幸的是，由于低温冷却和磁屏蔽要求带来的数百万美元的价格标签，MCG 系统几乎完全没有出现在临床实践中。物理光学公司提议开发一种低成本、非低温生物磁成像系统，适用于非屏蔽临床和护理点应用。