DEVELOPMENT OF A RHESUS MONKEY MODEL FOR IN UTERO CHIKUNGUNYA VIRUS INFECTION

子宫内基孔肯雅病毒感染的恒河猴模型的开发

• 批准号: 8172633
• 负责人: Aaron Cole Brault
• 金额: $ 7.74万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172633
• 关键词: Africa; Alphavirus; Arthralgia; Case Study; Characteristics; Chikungunya virus; Clinical; Computer Retrieval of Information on Scientific Projects Database; Culicidae; Development; Disease Outbreaks; Encephalopathies; Epidemic; Funding; Genotype; Grant; Human; India; Institution; Macaca mulatta; Modeling; Neonatal; Neurologic; Physiological; Research; Research Personnel; Resources; Source; Syndrome; United States National Institutes of Health; Virulence; Virus Diseases; fetal; improved; in utero; mouse model; nonhuman primate; novel; tissue tropism; transmission process; virus tropism

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Chikungunya virus (CHIKV) is a mosquito-borne alphavirus associated with epidemics of debilitating arthralgia in humans. From 2005-2007, a CHIKV genotype from East Africa crossed to India, leading to an outbreak with 2 million human cases reported. In addition to the outbreak magnitude, novel neurological syndromes were identified, including fetal encephalopathy associated with neonatal transmission. It remains to be determined whether the novel syndromes are the result of increased virulence, altered tissue tropism or are merely reflective of the outbreak size and improved case reporting. Although a CHIKV mouse model has recently been developed, non-human primates possess physiological characteristics more reflective of humans, thus allowing for a more accurate representation of human CHIKV tropism and clinical syndromes.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 Chikungunya病毒（Chikv）是一种蚊子传播的α病毒，与人类衰弱的亚属的流行病有关。从2005年至2007年，来自东非的CHIKV基因型越过印度，导致爆发了200万人案件。除爆发量外，还发现了新型神经系统综合征，包括与新生儿传播相关的胎儿脑病。新型综合征是毒力增加，组织对流改变还是仅仅反映爆发大小和改善病例报告的结果，还有待确定。尽管最近开发了Chikv小鼠模型，但非人类灵长类动物具有更大反映人类的生理特征，从而可以更准确地表示人类Chikv Tropism和临床综合征。