EFFECTS OF MERCURIC CHLORIDE ON MALE REPRODUCTION

氯化汞对男性生殖的影响

• 批准号: 7959273
• 负责人: HARI Om GOYAL
• 金额: $ 4.89万
• 依托单位: TUSKEGEE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-18 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7959273
• 关键词: Affect; Age; Area; Biomedical Research; Blood - brain barrier anatomy; Child; Computer Retrieval of Information on Scientific Projects Database; Control Groups; Diet; Female; Fertility Rates; Fetus; Fishes; Funding; Grant; Ingestion; Institution; Life; Mercuric chloride; Mercury; Partner in relationship; Pregnancy; Progress Reports; Rattus; Reporting; Reproduction; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Weight Gain; Woman; corpus luteum; drinking water; female reproductive system; implantation; male; young adult

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this study was to investigate effects of organic methyl mercury (MeHg) ingestion on the fertility rate of female rats, including (1) the number of viable fetuses, (2) the number of implantations, and the number of corpora lutea. Female rats, 30 days of age, were treated with 2.5 ppm (low treatment group) or 5.0 ppm (high treatment group) or 0.0 ppm MeHg (control group), in drinking water, for 60 days. They were then mated with 70 to 80-day-old untreated males (2 females to 1 male) for 17 days. Pregnancy was confirmed by weight increase. At 12-15 days of gestation, all females were euthanized and examined for the number of viable fetuses and implantations. Compared to controls, neither the number of viable fetuses, nor the number of implantations, and nor the number of corpora lutea was altered, as a result of MeHg treatment. Conversely, as reported previously in 2006-07 progress report, the ingestion of inorganic mercury resulted in lowering the mean number of fetuses (6.9 vs 12.4 in controls) as well as implantations (10.5 vs 12.8 in controls). In conclusion, while MeHg does not adversely affect the female reproductive system, inorganic mercury does. The difference between the two may lie in differences in their ability to cross the blood-brain-barrier, which is crossed by the MeHg but not by the inorganic mercury. These results are significant because they have a direct impact on young and adult women, especially child-bearing women, who live near coastal areas and depend upon fish as their main source of diet.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究的目的是研究有机甲基汞（MEHG）摄入对雌性大鼠的生育率的影响，包括（1）可行的胎儿数量，（2）植入数量和lutea的数量。 雌性大鼠30天，用2.5 ppm（低治疗组）或5.0 ppm（高治疗组）或0.0 ppm MEHG（对照组）在饮用水中治疗60天。然后，将他们与70至80天的未经治疗的雄性（2至1名男性）交配17天。体重增加证实了怀孕。妊娠12-15天，对所有女性进行了安乐死，并检查了可行的胎儿和植入的数量。 与对照组相比，由于MEHG治疗，既没有生存的胎儿数量，植入量的数量，植入数量也没有改变。 相反，正如先前在2006 - 07年度进度报告中报道的那样，无机汞的​​摄入导致降低胎儿的平均数量（对照组为6.9 vs 12.4）以及植入（对照组中的10.5 vs 12.8）。 总之，虽然MEHG不会对女性生殖系统产生不利影响，但无机汞确实如此。 两者之间的差异可能在于它们越过血脑屏障的能力差异，而脑部障碍物是由MEHG越过的，但不是无机汞。这些结果很重要，因为它们对居住在沿海地区附近并依靠鱼作为其主要饮食来源的年轻和成年妇女有直接影响。