STRUCTURAL STUDIES OF THE RNA INTERFERENCE MACHINERY

RNA干扰机制的结构研究

• 批准号: 7956452
• 负责人: IAN JOHN MACRAE
• 金额: $ 2.19万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7956452
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Family; Funding; Gene Silencing; Goals; Grant; Human; Institution; MicroRNAs; Microscopy; Molecular; Molecular Structure; Pathway interactions; RNA Interference; RNA-Induced Silencing Complex; Regulation; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Work; protein complex

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. RNA interference (RNAi) is a conserved mechanism of eukaryotic gene silencing and regulation. In humans RNAi and the related micro-RNA pathways are carried out by a family of large, related protein complexes, generically termed RNA induced silencing complexes (RISCs). The goal of this work is to determine molecular structures of the various forms of RISC in an effort to better understand the mechanism of gene silencing by RNAi.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 RNA干扰（RNAi）是真核基因沉默和调节的保守机制。在人类中，RNAi和相关的微RNA途径是由一个大型相关蛋白质复合物的家族进行的，通常称为RNA诱导的沉默复合物（RISC）。这项工作的目的是确定RISC的各种形式的分子结构，以更好地了解RNAi的基因沉默机制。