A MODEL-BASED INVESTIGATION OF FACE PROCESSING IN AUTISM

基于模型的自闭症面部处理研究

• 批准号: 7951990
• 负责人: Maximilian K Riesenhuber
• 金额: $ 1.3万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951990
• 关键词: Adult; Area; Autistic Disorder; Behavior; Behavioral; Brain; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Face; Face Processing; Functional Magnetic Resonance Imaging; Funding; Future; Grant; Human; Individual; Institution; Investigation; Learning; Measurement; Modeling; Neurologic; Observational Study; Play; Population; Process; Research; Research Personnel; Resources; Role; Series; Source; Testing; United States National Institutes of Health; Visual; autism spectrum disorder; base; design; developmental disease; face perception; fusiform face area; neuromechanism; novel; object recognition; predictive modeling; relating to nervous system; research study; social

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a series of observational studies to examine neural mechanisms underlying human face and object recognition in typically developing (TD) individuals and individuals with autism spectrum disorders (ASD). A significant number of research studies were previously conducted by this research team and others to determine brain mechanisms responsible for face processing. These studies have focused on obtaining qualitative measurements. The investigator for this project will use a quantitative and more predictive model to examine the process. The primary and secondary objectives are: 1) to examine neural mechanisms of visual object and face recognition and high level cortical plasticity in adults with TD and adults with ASD and related social developmental disorders and 2) to provide a baseline for future studies of neurological populations with object recognition deficits. The investigator proposes three separate studies. Each is described in detail and rationale is provided. Study I is designed to observe face recognition in the typical brain through a combination of model-based behavioral and functional Magnetic Resonance Imaging (fMRI) studies. It will focus on the "Fusiform Face Area" (FFA), an area of the brain that plays a key role in human face perception. In study II, the investigators will infer differences in neural processing by contrasting the results of fMRI and observed behavior between individuals with TD and ASD. In study III, they will test whether these processing differences between TD and ASD individuals extend to the learning of novel object classes. Each hypothesis is clearly stated and the investigator's approach to testing them is detailed and well documented.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 这是一系列观察性研究，旨在检查典型发育 (TD) 个体和自闭症谱系障碍 (ASD) 个体中人脸和物体识别的神经机制。该研究小组和其他人之前进行了大量研究，以确定负责面部处理的大脑机制。 这些研究的重点是获得定性测量。该项目的研究人员将使用定量且更具预测性的模型来检查该过程。主要和次要目标是：1) 检查 TD 成人和 ASD 及相关社会发展障碍成人的视觉对象和面部识别以及高水平皮质可塑性的神经机制，2) 为神经群体的未来研究提供基线具有物体识别缺陷。 研究人员提出了三项独立的研究。每个都进行了详细描述并提供了基本原理。 研究 I 旨在通过结合基于模型的行为和功能磁共振成像 (fMRI) 研究来观察典型大脑中的面部识别。它将重点关注“梭形面部区域”（FFA），这是一个在人类面部感知中发挥关键作用的大脑区域。 在研究 II 中，研究人员将通过对比 TD 和 ASD 个体的功能磁共振成像结果和观察到的行为来推断神经处理的差异。在研究 III 中，他们将测试 TD 和 ASD 个体之间的这些处理差异是否延伸到新物体类别的学习。 每个假设都得到了明确的阐述，研究者测试这些假设的方法也被详细记录并记录下来。