A MODEL-BASED INVESTIGATION OF FACE PROCESSING IN AUTISM

基于模型的自闭症面部处理研究

• 批准号: 7951990
• 负责人: Maximilian K Riesenhuber
• 金额: $ 1.3万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951990
• 关键词: Adult; Area; Autistic Disorder; Behavior; Behavioral; Brain; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Face; Face Processing; Functional Magnetic Resonance Imaging; Funding; Future; Grant; Human; Individual; Institution; Investigation; Learning; Measurement; Modeling; Neurologic; Observational Study; Play; Population; Process; Research; Research Personnel; Resources; Role; Series; Source; Testing; United States National Institutes of Health; Visual; autism spectrum disorder; base; design; developmental disease; face perception; fusiform face area; neuromechanism; novel; object recognition; predictive modeling; relating to nervous system; research study; social

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a series of observational studies to examine neural mechanisms underlying human face and object recognition in typically developing (TD) individuals and individuals with autism spectrum disorders (ASD). A significant number of research studies were previously conducted by this research team and others to determine brain mechanisms responsible for face processing. These studies have focused on obtaining qualitative measurements. The investigator for this project will use a quantitative and more predictive model to examine the process. The primary and secondary objectives are: 1) to examine neural mechanisms of visual object and face recognition and high level cortical plasticity in adults with TD and adults with ASD and related social developmental disorders and 2) to provide a baseline for future studies of neurological populations with object recognition deficits. The investigator proposes three separate studies. Each is described in detail and rationale is provided. Study I is designed to observe face recognition in the typical brain through a combination of model-based behavioral and functional Magnetic Resonance Imaging (fMRI) studies. It will focus on the "Fusiform Face Area" (FFA), an area of the brain that plays a key role in human face perception. In study II, the investigators will infer differences in neural processing by contrasting the results of fMRI and observed behavior between individuals with TD and ASD. In study III, they will test whether these processing differences between TD and ASD individuals extend to the learning of novel object classes. Each hypothesis is clearly stated and the investigator's approach to testing them is detailed and well documented.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这是一系列观察性研究，用于检查典型发育中的（TD）个体和患有自闭症谱系障碍（ASD）的个体（ASD）的个体中的神经机制和物体识别。以前，该研究团队和其他研究进行了大量研究，以确定负责面部处理的大脑机制。 这些研究的重点是获得定性测量。该项目的研究人员将使用定量和更具预测性的模型来检查该过程。主要和次要目标是：1）检查TD和患有ASD和相关社会发育障碍的成年人的视觉对象和面部识别和高水平皮质可塑性的神经机制，以及2）为未来对具有对象识别缺陷的神经群体的研究提供基线。 研究人员提出了三项独立的研究。详细描述了每个，并提供了理由。 研究I旨在通过基于模型的行为和功能磁共振成像（fMRI）研究的结合来观察典型大脑中的面部识别。它将集中在“梭形面部”（FFA）上，该区域在人脸感知中起着关键作用的大脑区域。 在研究II中，研究人员将通过对比fMRI的结果并观察到TD和ASD个体之间的行为来推断神经加工的差异。在研究III中，他们将测试TD和ASD个体之间的这些处理差异是否扩展到新的对象类别的学习。 清楚地说明了每个假设，研究者对测试它们的方法进行了详细介绍且有充分的文献记载。