STUDY OF CLOSED-LOOP GLUCOSE CONTROL IN PEOPLE WITH TYPE 1 DIABETES

1 型糖尿病患者的闭环血糖控制研究

• 批准号: 7951494
• 负责人: BORIS P KOVATCHEV
• 金额: $ 7.7万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951494
• 关键词: Accounting; Algorithms; Artificial Pancreas; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Computer Simulation; Coupled; Development; Diabetes Mellitus; Funding; Generic Drugs; Grant; Heart Rate; Individual; Institution; Insulin Infusion Systems; Insulin-Dependent Diabetes Mellitus; Metabolic; OGTT; Patients; Persons; Physical activity; Reaction; Research; Research Personnel; Resources; Source; System; Testing; United States National Institutes of Health; blood glucose regulation; glucose metabolism; glycemic control; in vivo; insulin sensitivity; pilot trial; research study; Accounting; Algorithms; Artificial Pancreas; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Computer Simulation; Coupled; Development; Diabetes Mellitus; Funding; Generic Drugs; Grant; Heart Rate; Individual; Institution; Insulin Infusion Systems; Insulin-Dependent Diabetes Mellitus; Metabolic; OGTT; Patients; Persons; Physical activity; Reaction; Research; Research Personnel; Resources; Source; System; Testing; United States National Institutes of Health; blood glucose regulation; glucose metabolism; glycemic control; in vivo; insulin sensitivity; pilot trial; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Increasing scientific and industrial effort is focused on the development of closed-loop systems (artificial pancreas) to control glucose metabolism in people with diabetes, particularly T1DM. Experiments are being conducted with CGM coupled with insulin pumps and a control algorithm. While such systems have proven feasible in steady metabolic states, they fail during changing metabolic demands, such as meals and physical activity. In order to account for such metabolic disturbances we have developed and tested in silico a new closed-loop control algorithm, which uses individual parameters of insulin sensitivity and heart rate. The proposed pilot trial will test this algorithm in vivo with T1DM patients who use insulin pumps to maintain glycemic control. Changes in heart rate will be used as a correlate to increased metabolic demand. If successful, this study will establish the following paradigm: instead of approaching a person "blindly" with a generic control algorithm, an initial test (e.g. oral glucose tolerance test) would allow setting individual parameters, which then will be used to initialize closed-loop control. This approach has the potential to overcome some of the current limitations of closed-loop control, particularly its inability to account for the highly idiosyncratic reaction of a person to metabolic disturbances, such as meals and physical activity.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 越来越多的科学和工业努力集中在闭环系统（人造胰腺）的开发上，以控制糖尿病患者，尤其是T1DM的葡萄糖代谢。实验是用CGM与胰岛素泵和对照算法进行的。尽管这种系统在稳定的代谢状态中已被证明是可行的，但它们在变化的代谢需求（例如膳食和体育锻炼）中失败。为了解释我们在硅中开发和测试的这种代谢障碍，一种新的闭环控制算法，该算法使用胰岛素敏感性和心率的个别参数。 拟议的试验试验将与使用胰岛素泵保持血糖控制的T1DM患者在体内测试该算法。心率的变化将与代谢需求增加相关。 如果成功，这项研究将建立以下范式：而不是通过通用控制算法“盲目地”接近一个人，而是初始测试（例如口服葡萄糖耐受性测试）将允许设置单个参数，然后将其用于初始化闭环控制。这种方法有可能克服闭环控制的某些当前局限性，尤其是无法解释一个人对代谢障碍（例如餐和体育活动）的高度特质反应。