ANTENATAL STEROIDS AND BLOOD PRESSURE IN CHILDHOOD

产前类固醇和儿童时期的血压

基本信息

批准号：
7951376
负责人：
LISA K WASHBURN
金额：
$ 5.84万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-03-01 至 2010-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7951376
关键词：
14 year old Animals Blood Pressure Child Childhood Clinical Research Computer Retrieval of Information on Scientific Projects Database Elderly Funding Grant Human Infant Institution Link Long-Term Effects Low Birth Weight Infant Lung Mothers Premature Birth Research Research Personnel Resources Source Steroids United States National Institutes of Health improved offspring pregnant response stressor

14 year old Animals Blood Pressure Child Childhood Clinical Research Computer Retrieval of Information on Scientific Projects Database Elderly Funding Grant Human Infant Institution Link Long-Term Effects Low Birth Weight Infant Lung Mothers Premature Birth Research Research Personnel Resources Source Steroids United States National Institutes of Health improved offspring pregnant response stressor

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项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Antenatal steroids are commonly given to pregnant mothers with threatened preterm delivery to help the infant's lungs mature. This therapy has improved the survival of very low birthweight infants by 40%. However, animal studies have linked the use of antenatal steroids to elevated blood pressure in exposed offspring in later life. Studies in humans have shown elevated blood pressure at 14 years of age in children whose mothers received antenatal steroids. This study will allow us to evaluate the long term effects of antenatal steroids on blood pressure and blood pressure response to stressors in former very low birthweight infants at age 14 years.

该副本是利用众多研究子项目之一由NIH/NCRR资助的中心赠款提供的资源。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构是对于中心，这不一定是调查员的机构。产前类固醇通常给怀孕的母亲，以威胁性早产，以帮助婴儿的肺部成熟。这种疗法将非常低的出生体重婴儿的存活率提高了40％。然而，动物研究已将产前类固醇的使用与以后的后代中的血压升高有关。在人类接受产前类固醇的儿童中，人类的研究表明，在14岁时的血压升高。这项研究将使我们能够评估产前类固醇对14岁以前非常低的出生体重婴儿血压和血压反应的长期影响。