Natural History of Urban Leptospirosis

城市钩端螺旋体病的自然史

• 批准号: 7762809
• 负责人: Albert Icksang Ko
• 金额: $ 7.06万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-02-15 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7762809
• 关键词: Acute Kidney Failure; Address; Affect; Awareness; Brazil; Cities; Climate; Clinical; Communicable Diseases; Communities; Databases; Disease; Disease Outbreaks; Drainage procedure; Enrollment; Environmental Risk Factor; Epidemic; Epidemiology; Exposure to; Floods; Funding; Geography; Goals; Health; Hemorrhage; Incidence; Infection; Information Systems; Intervention; Intervention Studies; Investigation; Laboratories; Lead; Leptospira; Leptospirosis; Life; Local Government; Longitudinal Studies; Lung; Modeling; Natural History; Order Spirochaetales; Outcome; Outcome Measure; Outpatients; Pattern; Policies; Population; Poverty; Prevention; Prophylactic treatment; Prospective Studies; Rattus; Recommendation; Recruitment Activity; Reporting; Research; Research Infrastructure; Risk; Risk Factors; Sample Size; Sanitation; Sewage; Site; Slum; Socioeconomic Factors; Spatial Distribution; Statistical Models; Surveys; Syndrome; System; Testing; Time; Universities; Urban Population; Urbanization; Variant; Weil' s Disease; World Bank; base; cohort; effectiveness measure; follow-up; improved; medical schools; prevent; programs; prospective; public health relevance; socioeconomics; transmission process

DESCRIPTION (provided by applicant): Leptospirosis is a paradigm for an urban slum health problem. Rapid urbanization and expanding urban poverty, together with climate, have created conditions for rat-borne transmission of the Leptospira spirochete. Epidemics occur each year in slum communities during seasonal periods of heavy rainfall and are associated with life-threatening manifestations such as acute renal failure and pulmonary hemorrhage. Interventions need to focus on prevention since case fatality is >10% despite aggressive treatment. A major barrier to identifying interventions has been the lack of prospective studies on leptospirosis. We conducted a prospective cohort investigation of 9,863 residents from a slum community in the city of Salvador. Brazil. We found that 3.6% of the community was infected each year with Leptospira. Exposures to defined infrastructure deficiencies related to open sewers and flooding were the major risk factors for infection. These findings led us to hypothesize that effective prevention of urban leptospirosis requires providing slum communities with adequate sewage and drainage systems. Furthermore, active surveillance which we conducted since 1996 identified a four-fold decline in the incidence of severe leptospirosis. This decline was unrelated to temporal variations in climate and coincided with implementation of a World Bank-funded sanitation program, which increased the coverage of the population with closed sewage systems from 26 to 68%. Improved sanitation may therefore have an impact in preventing the severe outcomes from leptospirosis. There is little information on the impact of large-scale sanitation programs in preventing infectious diseases, outside of diarrheal disease. Our findings convinced the local government to construct closed sewage systems at our cohort site and other slum communities in the periphery of Salvador. In the 1st project aim, we will perform an intervention study and prospectively determine whether a large-scale sanitation project is effective in preventing leptospirosis. We will enroll a cohort at our site and measure outcomes of Leptospira infection and disease during annual serosurveys and outpatient surveillance. In the 2nd project aim, we will identify the temporal and spatial determinants for leptospirosis in a large urban center and evaluate whether implementation of a municipal sanitation program contributed to an observed decline in severe disease incidence. We have created a large database on climate, environmental attributes and demographic and socioeconomic indicators for Salvador and will use this information to model the effect of improved sanitation on the risk for leptospirosis across time and space. We expect that the information gained from the project will lead to policy recommendations for the prevention of urban leptospirosis, which is urgently needed as the population residing in slum doubles from one to two billion in the next twenty years. Furthermore, the project's findings will likely be relevant to the control of the large number of environmentally-transmitted infectious diseases that affect impoverished urban populations. PUBLIC HEALTH RELEVANCE There is no effective prevention for leptospirosis, a severe life-threatening disease that is the cause of rat-borne epidemics among impoverished urban slum populations worldwide. The research proposed here aims to determine the impact of a large-scale sanitation project in preventing leptospirosis in a slum community in Brazil. The information gained from the project will lead to policy recommendations, which are needed to address leptospirosis in regions of the world where slum settlements are rapidly expanding.

描述（由申请人提供）：钩端螺旋体病是城市贫民窟健康问题的一个范例。快速的城市化和不断扩大的城市贫困，加上气候，为钩端螺旋体通过老鼠传播创造了条件。每年在强降雨季节期间，贫民窟社区都会发生流行病，并与急性肾功能衰竭和肺出血等危及生命的症状有关。干预措施需要注重预防，因为尽管采取了积极治疗，病死率仍>10%。确定干预措施的一个主要障碍是缺乏对钩端螺旋体病的前瞻性研究。我们对萨尔瓦多市贫民窟社区的 9,863 名居民进行了前瞻性队列调查。巴西。我们发现每年有 3.6% 的社区感染钩端螺旋体。暴露于与露天下水道和洪水相关的特定基础设施缺陷是感染的主要风险因素。这些发现使我们推测，有效预防城市钩端螺旋体病需要为贫民窟社区提供充足的污水和排水系统。此外，我们自 1996 年以来进行的主动监测发现，严重钩端螺旋体病的发病率下降了四倍。这一下降与气候的时间变化无关​​，并且与世界银行资助的卫生项目的实施同时发生，该项目将封闭污水系统的人口覆盖率从 26% 增加到 68%。因此，改善卫生条件可能有助于预防钩端螺旋体病的严重后果。关于大规模卫生项目对预防腹泻病以外的传染病的影响的信息很少。我们的研究结果说服当地政府在我们的队列地点和萨尔瓦多周边的其他贫民窟社区建造封闭式污水系统。在第一个项目目标中，我们将进行一项干预研究，并前瞻性地确定大型卫生项目是否能有效预防钩端螺旋体病。我们将在我们的现场招募一个队列，并在年度血清调查和门诊监测期间测量钩端螺旋体感染和疾病的结果。在第二个项目目标中，我们将确定大城市中心钩端螺旋体病的时间和空间决定因素，并评估市政卫生计划的实施是否有助于观察到的严重疾病发病率下降。我们为萨尔瓦多创建了一个关于气候、环境属性以及人口和社会经济指标的大型数据库，并将利用这些信息来模拟改善卫生条件对跨时间和空间的钩端螺旋体病风险的影响。我们期望从该项目中获得的信息将产生预防城市钩端螺旋体病的政策建议，随着居住在贫民窟的人口在未来二十年从 10 亿翻倍到 20 亿，这是迫切需要的。此外，该项目的研究结果可能与控制影响贫困城市人口的大量环境传播传染病有关。公共卫生相关性 钩端螺旋体病尚无有效预防方法，钩端螺旋体病是一种严重危及生命的疾病，是全世界贫困城市贫民窟人口中老鼠传播流行病的原因。这里提出的研究旨在确定大规模卫生项目对预防巴西贫民窟社区钩端螺旋体病的影响。从该项目中获得的信息将产生政策建议，这些建议是解决世界上贫民窟快速扩张地区的钩端螺旋体病问题所必需的。