Validation and domain development in mental health and sleep-wake function

心理健康和睡眠觉醒功能的验证和领域开发

• 批准号: 7780843
• 负责人: Paul A Pilkonis
• 金额: $ 132.74万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-28 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7780843
• 关键词: Address; African American; Age; American; Anger; Anxiety; Area; Attention Concentration; Beck depression inventory; Calibration; Chronic Disease; Chronic Insomnia; Collaborations; Country; Decision Making; Development; Diagnosis; Elderly; Evaluation; Goals; Health Sciences; Health Services Research; Health Status; Impaired cognition; Individual; Information Systems; Internet; Intervention; Life; Louisiana; Measurement; Measures; Medicine; Memory; Mental Health; Minority; Mood Disorders; Obstructive Sleep Apnea; Outcome Measure; Participant; Patient Outcomes Assessments; Patient Self-Report; Patients; Population; Principal Investigator; Psychiatry; Public Health; Race; Recruitment Activity; Reporting; Research; Respondent; Sampling; Self Perception; Simulate; Site; Sleep; Sleep Disorders; Sleep disturbances; Suicide; Surveys; System; Universities; Validation; Work; Wrist; actigraphy; age related; depression; diaries; emotional distress; high risk; instrument; member; novel; programs; prospective; psychologic; public health relevance; simulation; systems research; young adult

DESCRIPTION (provided by applicant): The goal of the Patient-Reported Outcomes Measurement Information System (PROMIS) is to develop an adaptive system for measuring outcomes in chronic diseases. The University of Pittsburgh has served as a PROMIS research site since 2004, focusing on the domains of emotional distress and sleep-wake function. We developed 5 PROMIS item banks (depression, anxiety, anger, sleep disturbance, and wake disturbance) of the 11 currently available. This renewal application will continue and extend our earlier work (a) by validating further the item banks we have developed using new samples, underrepresented groups (African Americans and older adults), and longitudinal analyses and (b) by developing new item banks in a complementary area of mental health-positive psychological functioning. Our specific aims are (1) to validate further the PROMIS item banks for emotional distress by demonstrating the feasibility and value of CAT administration; by examining in a more definitive way differential item functioning (DIF) for race and age; and by establishing the greater sensitivity to change of the PROMIS measures compared to conventional legacy instruments in a high-risk population-geriatric patients with depression; (2) to validate further the PROMIS sleep disturbance and wake disturbance item banks with work on construct validity (comparing known groups with clinically diagnosed sleep disorders versus no sleep disorder); convergent and discriminant validity using other common retrospective, qualitative sleep-wake measures and prospective, quantitative assessments (sleep diaries, wrist actigraphy); and treatment responsiveness and minimal important differences by following patients with sleep disorders from initial evaluation through 6-8 weeks of treatment; (3) to examine longitudinal and reciprocal relationships between emotional distress and sleep-wake function by administering these banks prospectively in 4 waves over the course of 12 months to a sample of participants from the RAND American Life Panel; and (4) to develop new item banks to evaluate positive psychological functioning, an area of mental health in the PROMIS domain framework complementary to our work on emotional distress. In all studies, we propose to investigate the value of the comprehensive PROMIS health status profile (i.e., assessments across all 11 current PROMIS item banks) for identifying novel associations between domains and novel profiles of patients with chronic diseases. Our work will involve collaboration with various research groups within the University of Pittsburgh and across the country (RAND, Duke University, and LSU Health Sciences Center-Shreveport). PUBLIC HEALTH RELEVANCE: Our proposed new studies will enhance the value and public health impact of PROMIS by including new samples of older adults and minority populations; examining the utility of PROMIS measures in applied treatment contexts; evaluating longitudinal relationships between the domains of mental health and sleep- wake function; utilizing CAT to maximize efficiency in real-world settings; and demonstrating the value of the overall health status profile that can be derived from all available PROMIS item banks.

描述（由申请人提供）：患者报告的结果测量信息系统（PROMIS）的目标是开发一种自适应系统，用于测量慢性病的结果。匹兹堡大学自2004年以来一直担任Promis研究站点，重点是情绪困扰和睡眠效果。我们开发了5个Promis物品库（抑郁，焦虑，愤怒，睡眠障碍和唤醒障碍）。该更新应用程序将继续并扩展我们的早期工作（a），进一步验证我们使用新样本，代表性不足的群体（非裔美国人和老年人）以及纵向分析以及（b）通过在心理健康心理阳性心理功能互补的互补领域中开发新项目库来验证我们已经开发的项目库。我们的具体目的是（1）通过证明猫管理的可行性和价值来进一步验证Promis物品库，以造成情绪困扰；通过以更确切的方式检查种族和年龄的差异项目功能（DIF）；与在抑郁症患者中的常规传统仪器相比，与传统的遗产工具相比，建立了对变化措施的更高敏感性； （2）进一步验证Promis的睡眠障碍和唤醒障碍项目库，其工作有效性（比较已知的临床诊断为睡眠障碍与无睡眠障碍的人）；使用其他常见的回顾性，定性睡眠措施和前瞻性，定量评估（睡眠日记，腕部行为），收敛性和判别有效性；从初步评估到治疗6-8周的睡眠障碍患者，治疗反应能力和最小的重要差异； （3）通过在12个月的时间内以4次浪潮管理这些银行来检查情绪困扰与睡眠效果功能之间的纵向和相互关系，以从Rand American Life Panel的参与者样本中进行样本； （4）开发新项目库来评估积极的心理功能，这是Promis领域框架中精神健康的领域，以互补我们在情绪困扰方面的工作。在所有研究中，我们建议研究综合的Promis健康状况概况的价值（即所有11个当前的Promis物品库评估），以识别域与慢性疾病患者的新概况之间的新型关联。我们的工作将涉及与匹兹堡大学和全国各地的各种研究小组（兰德，杜克大学和LSU健康科学中心且繁华）的合作。公共卫生相关性：我们拟议的新研究将通过包括新老年人和少数群体的新样本来增强Promis的价值和公共卫生影响；在应用治疗环境中检查Promis措施的实用性；评估心理健康和睡眠唤醒功能领域之间的纵向关系；利用CAT在现实世界中最大化效率；并证明可以从所有可用的Promis物品库中得出的总体健康状况概况的价值。