Pathogenesis of Calcium Nephrolithiasis

钙肾结石的发病机制

• 批准号: 7688019
• 负责人: FREDERIC L COE
• 金额: $ 66.7万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7688019
• 关键词: Pathogenesis; Calcium; Nephrolithiasis

DESCRIPTION, OVERALL (provided by applicant): Our research involves specific aims distributed among three projects served by three cores. Of these, some are currently in progress as a result of new findings discovered during the present grant period. The remainder represent new projects. Almost all of the protocols depend upon collaborative relationships between at least 2 projects, and draw upon at least one core. Project by Coe uses human subjects in highly focused clinical research center (CRC) protocols aimed at understanding the pathophysiology of plaque, CD plugging and stone formation in terms of hormonal and mineral dynamics related to feeding. Project by Lingeman plans continued mapping and biopsy of the many SF phenotypes we have not yet studies. Project by Evan plans continued histopathologic and mineral analysis of SF biopsies. We plan a critical experiment to determine whether the initial plaque site is the ascending or the descending limb of the THL. We will continue to produce analyses of SF patient groups in terms of treatment outcomes and phenotype characterization.

描述，总体（由申请人提供）： 我们的研究涉及在三个核心服务的三个项目中分布的特定目标。其中，由于本赠款期间发现的新发现，目前正在进行中。其余代表新项目。几乎所有协议都取决于至少两个项目之间的协作关系，并借鉴了至少一个核心。 COE的项目在高度重点的临床研究中心（CRC）方案中使用人类受试者，旨在了解与喂养相关的荷尔蒙和矿物质动力学，以了解斑块，CD塞和石材形成的病理生理学。 Lingeman计划的项目继续映射和活检我们尚未研究的许多SF表型。 Evan计划的项目继续组织病理学和SF活检的矿物质分析。我们计划一个关键的实验，以确定初始斑块位点是THL的上升或下降的肢体。我们将在治疗结果和表型表征方面继续对SF患者组进行分析。