Age-related changes in proximal femoral strength in men and women

男性和女性近端股骨强度与年龄相关的变化

• 批准号: 7825279
• 负责人: THOMAS F LANG
• 金额: $ 35.73万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-15 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7825279
• 关键词: Accounting; Age; Anthropometry; Area; Body Weight; Bone Density; Characteristics; Clinical; Data; Development; Elderly; Elements; Environment; Evaluation; Failure; Femur; Finite Element Analysis; Fracture; Gender; Height; Hip Fractures; Hip region structure; Incidence; Lateral; Longitudinal Studies; Maps; Measurement; Measures; Modeling; Muscle; Neck; Non-linear Models; Patients; Performance; Property; Prospective Studies; Registries; Research Personnel; Resolution; Risk; Scanning; Side; Simulate; Structure; Structure of greater trochanter of femur; Study models; System; Techniques; Trochanters; Visit; Woman; X-Ray Computed Tomography; age effect; age related; aging gene; analytical method; bone; bone geometry; bone strength; clinically relevant; cohort; density; fall risk; falls; frailty; image registration; improved; indexing; men; programs; prospective; time interval

DESCRIPTION (provided by applicant): The exponential increase in hip fracture incidence with age cannot be explained either by the age-related decrease in area! bone mineral density (aBMD) or by the increase of fall risk with age. Recent studies have outlined age-related changes in hip structure that appear to result in increased fragility but that may not be reflected in bone density measurements. We propose to examine the effect of aging on proximal femoral structure and strength and to relate these measures to hip fracture risk. To accomplish this end, we will carry out two studies using quantitative computed tomography (QCT): a longitudinal study to examine age-related changes in proximal femoral geometry and strength and a prospective study relating these properties to incident hip fracture. The analytical methods will include structural analysis of the hip from high resolution QCT scans and patient specific finite element modeling (FEM) to estimate hip strength in loading conditions simulating a single-legged stance and a fall to the side. Our longitudinal cohort will be a subset of 500 patients selected from the 5000 elderly subjects in the Age Gene/Environment -Reykjavik (AGES-R) study. In the prospective fracture study the AGES-R fracture registry will be employed to determine which of the subjects scanned at baseline have sustained fracture of the hip. The scans of these subjects will be analyzed along with a set of gender and age-matched controls. In this study, we expect to derive clinically relevant information regarding the effect regarding how the structural characteristics of the proximal femur and its strength change with age and how they contribute to fracture risk.

描述（由申请人提供）：髋部骨折发生率随年龄呈指数增加也不能用与年龄相关的面积减少来解释！骨矿物质密度 (aBMD) 或随着年龄的增长跌倒风险增加。最近的研究概述了髋部结构与年龄相关的变化，这些变化似乎会导致脆性增加，但可能不会反映在骨密度测量中。我们建议检查衰老对近端股骨结构和强度的影响，并将这些措施与髋部骨折风险联系起来。为了实现这一目标，我们将使用定量计算机断层扫描 (QCT) 开展两项研究：一项纵向研究，旨在检查股骨近端几何形状和强度与年龄相关的变化；一项前瞻性研究，将这些特性与髋部骨折的发生联系起来。分析方法将包括通过高分辨率 QCT 扫描对髋部进行结构分析和患者特定的有限元建模 (FEM)，以估计模拟单腿站立和侧倒的负载条件下的髋部强度。我们的纵向队列将是从年龄基因/环境-雷克雅未克 (AGES-R) 研究的 5000 名老年受试者中选出的 500 名患者的子集。在前瞻性骨折研究中，AGES-R 骨折登记将用于确定基线扫描的受试者中哪些人患有持续性髋部骨折。这些受试者的扫描结果将与一组性别和年龄匹配的对照一起进行分析。在这项研究中，我们期望获得有关股骨近端结构特征及其强度如何随年龄变化以及它们如何影响骨折风险的临床相关信息。