Integrative Analysis of Change in Cognition and Health

认知变化与健康的综合分析

• 批准号: 7932128
• 负责人: SCOTT M. HOFER
• 金额: $ 37.05万
• 依托单位: UNIVERSITY OF VICTORIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-15 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7932128
• 关键词: Accounting; Address; Affect; Age; Age-Years; Aging; Aging-Related Process; Attention; Behavioral; Birth; Cardiovascular Diseases; Cessation of life; Characteristics; Code; Cognition; Cognitive; Cognitive aging; Collaborations; Comorbidity; Complex; Coupled; Data; Data Analyses; Data Set; Databases; Dementia; Development; Diabetes Mellitus; Disease; Disease Progression; Early identification; Education; Educational workshop; Ensure; Evaluation; Event; Exhibits; Future; Gait; Health; Health Policy; Health Status; Health behavior; Heterogeneity; Horns; Hypertension; Individual; Individual Differences; International; Intervention; Knowledge; Lead; Life; Link; Longitudinal Studies; Measurement; Measures; Mediating; Mediation; Mental Health; Modeling; Morbidity - disease rate; Motivation; Multivariate Analysis; National Research Council; Outcome; Paper; Patient Self-Report; Pattern; Performance; Persons; Population; Preventive Intervention; Principal Investigator; Procedures; Process; Productivity; Protocols documentation; Psychological Models; Psychological Theory; Psychosocial Influences; Publishing; Recommendation; Reporting; Research; Research Infrastructure; Research Personnel; Residual state; Resources; Risk Factors; Role; Sampling; Science; Sensitivity and Specificity; Sensory; Short-Term Memory; Signal Transduction; Social support; Specificity; Speed; Statistical Methods; Structure; Techniques; Testing; Theoretical model; Time; Time Study; Variant; Work; abstracting; age difference; age related; age related cognitive change; aging mind; base; cerebrovascular; cognitive change; cognitive function; cognitive system; depressive symptoms; design; direct application; disease diagnosis; expectation; functional outcomes; grasp; improved; innovation; instrument; interest; loss of function; meetings; mortality; multidisciplinary; population based; programs; psychosocial; research and development; respiratory; social; theories; web site

DESCRIPTION (provided by applicant): This program of research focuses on aging-related changes in cognition and health, and in explaining cognitive change in the context of health and health-related change (i.e., morbidity, comorbidity). A key objective is to identify processes of change other than chronological age (i.e., simple passage of time) that account for population and individual-level change in cognitive functions. Identification of processes of change will proceed through detailed consideration of within-person change in health indicators (morbidity and comorbidity) and patterns of change prior to death. Contributions to theory include focused attention on health as a causal factor in aging-related changes and the role of sociodemographic and psychosocial influences in predicting changes in health and moderating the health-cognitive link. Using a within-person perspective, strong tests will be made of psychological theories of cognitive aging (speed and sensory mediation, common cause), developed primarily on the basis of age differences. Methodological features include inference to defined populations of aging individuals conditional on mortality-selection, multivariate analysis of correlated and coupled change, estimation of change-points, and cross-national generalizability. This project brings together multidisciplinary teams of investigators from 21 longitudinal studies on aging. A coordinated and collaborative approach to the integrative understanding of aging, health, and cognition will lead to significant gains in knowledge from these longitudinal studies and permit the identification and reconciliation of differences found across studies in terms of measurement, sampling, demographic, social, and health indicators. This broad collaboration has extensive multidisciplinary expertise and interdisciplinary interests. The diversity of perspectives is maintained in the development of analysis protocols, ensuring generalizability of results and evaluation of the sensitivity of results to decisions regarding measurement harmonization, analysis, and choice of theoretical models, while maximizing data value from each study. The findings from this research program will provide a basis for prevention and intervention efforts and inform health policy by identifying premorbid and subsequent changes associated with morbidity and comorbidity, and sociodemographic and psychosocial moderators of these changes. Potential interventions will be enhanced by early identification of change-points signaling subsequent loss of function and mortality.

描述（由申请人提供）：该研究计划的重点是与衰老相关的认知和健康变化，以及在健康和健康相关变化的背景下解释认知变化（即发病率，合并症）。一个关键目的是确定除时间年龄以外的变化过程（即，时间的简单流逝）来解释人口的认知功能和个人级别的变化。识别变更过程将通过详细考虑健康指标内部变更（发病率和合并症）以及死亡前变更模式进行。对理论的贡献包括将关注健康作为与衰老有关的变化的因果因素以及社会人口统计学和社会心理影响在预测健康变化和调节健康认知联系方面的作用。利用人际关系的观点，将对认知衰老的心理学理论（速度和感觉调解，共同原因）进行强有力的检验，主要是基于年龄差异而开发的。方法论特征包括针对老龄化个体的定义人群的推断，条件是死亡率选择，相关和耦合变化的多元分析，变更点的估计以及跨国通用性。该项目汇集了来自21个关于衰老纵向研究的研究人员的多学科团队。对衰老，健康和认知的综合理解的协调和协作方法将导致这些纵向研究的知识获得可观的收益，并允许在测量，取样，人口统计学，社会和健康指标方面对整个研究发现的差异的识别和和解。这种广泛的合作具有广泛的多学科专业知识和跨学科利益。观点的多样性在分析方案的开发中保持了多样性，确保结果的普遍性以及对结果对测量协调，分析和理论模型的选择的敏感性的评估，同时从每项研究中最大化数据值。该研究计划的调查结果将通过确定与发病率和合并症相关的前牙前和随后的变化以及这些变化的社会人口统计学和社会心理主持人，为预防和干预工作提供基础。通过早期识别变更点的信号传递随后的功能和死亡率丧失，可以增强潜在干预措施。