Integrative Analysis of Change in Cognition and Health

认知变化与健康的综合分析

基本信息

批准号：
7932128
负责人：
SCOTT M. HOFER
金额：
$ 37.05万
依托单位：
UNIVERSITY OF VICTORIA
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-15 至 2012-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7932128
关键词：
Accounting Address Affect Age Age-Years Aging Aging-Related Process Attention Behavioral Birth Cardiovascular Diseases Cessation of life Characteristics Code Cognition Cognitive Cognitive aging Collaborations Comorbidity Complex Coupled Data Data Analyses Data Set Databases Dementia Development Diabetes Mellitus Disease Disease Progression Early identification Education Educational workshop Ensure Evaluation Event Exhibits Future Gait Health Health Policy Health Status Health behavior Heterogeneity Horns Hypertension Individual Individual Differences International Intervention Knowledge Lead Life Link Longitudinal Studies Measurement Measures Mediating Mediation Mental Health Modeling Morbidity - disease rate Motivation Multivariate Analysis National Research Council Outcome Paper Patient Self-Report Pattern Performance Persons Population Preventive Intervention Principal Investigator Procedures Process Productivity Protocols documentation Psychological Models Psychological Theory Psychosocial Influences Publishing Recommendation Reporting Research Research Infrastructure Research Personnel Residual state Resources Risk Factors Role Sampling Science Sensitivity and Specificity Sensory Short-Term Memory Signal Transduction Social support Specificity Speed Statistical Methods Structure Techniques Testing Theoretical model Time Time Study Variant Work abstracting age difference age related age related cognitive change aging mind base cerebrovascular cognitive change cognitive function cognitive system depressive symptoms design direct application disease diagnosis expectation functional outcomes grasp improved innovation instrument interest loss of function meetings mortality multidisciplinary population based programs psychosocial research and development respiratory social theories web site

项目摘要

DESCRIPTION (provided by applicant): This program of research focuses on aging-related changes in cognition and health, and in explaining cognitive change in the context of health and health-related change (i.e., morbidity, comorbidity). A key objective is to identify processes of change other than chronological age (i.e., simple passage of time) that account for population and individual-level change in cognitive functions. Identification of processes of change will proceed through detailed consideration of within-person change in health indicators (morbidity and comorbidity) and patterns of change prior to death. Contributions to theory include focused attention on health as a causal factor in aging-related changes and the role of sociodemographic and psychosocial influences in predicting changes in health and moderating the health-cognitive link. Using a within-person perspective, strong tests will be made of psychological theories of cognitive aging (speed and sensory mediation, common cause), developed primarily on the basis of age differences. Methodological features include inference to defined populations of aging individuals conditional on mortality-selection, multivariate analysis of correlated and coupled change, estimation of change-points, and cross-national generalizability. This project brings together multidisciplinary teams of investigators from 21 longitudinal studies on aging. A coordinated and collaborative approach to the integrative understanding of aging, health, and cognition will lead to significant gains in knowledge from these longitudinal studies and permit the identification and reconciliation of differences found across studies in terms of measurement, sampling, demographic, social, and health indicators. This broad collaboration has extensive multidisciplinary expertise and interdisciplinary interests. The diversity of perspectives is maintained in the development of analysis protocols, ensuring generalizability of results and evaluation of the sensitivity of results to decisions regarding measurement harmonization, analysis, and choice of theoretical models, while maximizing data value from each study. The findings from this research program will provide a basis for prevention and intervention efforts and inform health policy by identifying premorbid and subsequent changes associated with morbidity and comorbidity, and sociodemographic and psychosocial moderators of these changes. Potential interventions will be enhanced by early identification of change-points signaling subsequent loss of function and mortality.

描述（由申请人提供）：该研究项目重点关注与衰老相关的认知和健康变化，并解释健康和健康相关变化（即发病率、合并症）背景下的认知变化。一个关键目标是确定除实际年龄（即简单的时间流逝）之外的变化过程，这些变化过程可以解释人口和个体水平的认知功能变化。将通过详细考虑人体内健康指标（发病率和合并症）的变化以及死亡前的变化模式来识别变化过程。对理论的贡献包括关注健康作为衰老相关变化的因果因素，以及社会人口和心理社会影响在预测健康变化和调节健康与认知联系中的作用。将从个人角度出发，对主要基于年龄差异而发展起来的认知衰老心理学理论（速度和感觉中介，共同原因）进行强有力的测试。方法论特征包括以死亡率选择为条件推断确定的老龄化个体群体、相关和耦合变化的多变量分析、变化点的估计以及跨国普遍性。该项目汇集了来自 21 项老龄化纵向研究的多学科研究人员团队。对衰老、健康和认知进行综合理解的协调和协作方法将导致从这些纵向研究中获得知识的显着增长，并允许识别和协调研究中在测量、抽样、人口统计、社会和认知方面发现的差异。健康指标。这种广泛的合作具有广泛的多学科专业知识和跨学科兴趣。在分析方案的制定过程中保持观点的多样性，确保结果的普遍性以及评估结果对有关测量协调、分析和理论模型选择的决策的敏感性，同时最大化每项研究的数据价值。该研究计划的结果将为预防和干预工作提供基础，并通过确定与发病和合并症相关的病前和随后的变化以及这些变化的社会人口和心理社会调节因素来为卫生政策提供信息。通过及早识别预示随后功能丧失和死亡的变化点，可以加强潜在的干预措施。