2008-2011Metals in Biology Gordon Research Conference and Associated Graduate Res

2008-2011戈登生物学金属研究会议及相关研究生研究

• 批准号: 7751210
• 负责人: Julia A Kovacs
• 金额: $ 0.4万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-01-10 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7751210
• 关键词: Address; Anabolism; Antibiotics; Area; Bioinorganic Chemistry; Biology; Catalysis; Chemicals; Chemistry; Collaborations; Communities; Complex; DNA; Detection; Drug Metabolic Detoxication; Electron Transport; Electrons; Enzymes; Evolution; Fostering; Future; Goals; Health; Hormones; Ions; Iron; Leukotrienes; Ligands; Metals; Molecular; Neurotransmitters; Oxidative Stress; Participant; Pathway interactions; Physics; Play; Process; Protons; Reactive Oxygen Species; Request for Proposals; Research; Role; Steroids; Sulfur; abstracting; catalyst; meetings; member; metalloenzyme; posters; programs; symposium

DESCRIPTION (provided by applicant): Abstract: This proposal requests three years of partial support for the Metals in Biology Gordon Research Conference (MIB GRC) and its descendent, the Gordon-Kenan Bioinorganic Graduate Research Seminar (MIB GK-GRS), to be held annually in Ventura, CA in late January. Metal ions play critical roles in over one third of all enzymes, and are involved in a number of important health related biosynthetic pathways including the conversion of electrochemical to chemical energy, and the biosynthesis of antibiotics, DNA, neurotransmitters, steroids, leukotrienes, and hormones. The molecular level details regarding metalloenzyme function emerge from several complementary lines of study, at the interface of chemistry, biology, and physics. The broad and long term goal of these conferences are to foster discussion and collaborations in a highly interdisciplinary area of research, and nurture the younger members of our community by providing them with their own sense of community, and allowing the future leaders of our field to emerge. The significance of this application is that the MIB GRC provides the principal forum for the discussion of research at the forefront of bioinorganic chemistry. The specific aims of this meeting will be to convene ~27 speakers that represent critical areas of metal ions in biology research with a total of 150 participants for a five day conference in a relatively isolated setting. The program will have a keynote address and nine sessions that broadly address current issues in proton-coupled electron transfer, the assembly and evolution of iron sulfur clusters as electron transport agents and catalysts for complex multi electron processes, the role played by sulfur ligands in promoting metalloenzyme function, metal ion-promoted 0-0 bond formation and cleavage, the detection and detoxification of reactive oxygen species formed under oxidative stress, and bioinspired catalysis. In addition, two evening poster sessions will permit all of the conferees to contribute to the discussion of these topics. Metal ions play critical roles in over one third of all enzymes, and are involved in a number of important biosynthetic pathways including the conversion of electrochemical to chemical energy, and the biosynthesis of antibiotics, DNA, neurotransmitters, steroids, leukotrienes, and hormones. The molecular level details regarding metalloenzyme function emerge from several complementary lines of study, at the interface of chemistry, biology, and physics. Both the formal and informal discussions associated with the MIB GRC meeting are critical to the advancement of the field, and fostering collaborations in this highly interdisciplinary area of research.

描述（由申请人提供）： 摘要：该提案要求为戈登生物学金属研究会议 (MIB GRC) 及其衍生项目戈登-凯南生物无机研究生研究研讨会 (MIB GK-GRS) 提供三年的部分支持，每年一月下旬在加利福尼亚州文图拉举行。 金属离子在超过三分之一的酶中发挥着关键作用，并参与许多与健康相关的重要生物合成途径，包括电化学能到化学能的转化，以及抗生素、DNA、神经递质、类固醇、白三烯和激素的生物合成。有关金属酶功能的分子水平细节来自于化学、生物学和物理学交叉领域的几个互补的研究领域。 这些会议的广泛和长期目标是促进高度跨学科研究领域的讨论和合作，并通过为我们社区的年轻成员提供自己的社区意识来培养他们，并让我们领域的未来领导者能够出现。 该应用的意义在于，MIB GRC 为生物无机化学前沿研究的讨论提供了主要论坛。 本次会议的具体目标是召集约 27 位代表生物学研究中金属离子关键领域的发言人，总共 150 名与会者，在相对孤立的环境中举行为期五天的会议。 该计划将有一个主题演讲和九场会议，广泛讨论质子耦合电子转移、铁硫簇作为复杂多电子过程的电子传输剂和催化剂的组装和演化、硫配体在促进金属酶功能、金属离子促进的0-0键形成和裂解、氧化应激下形成的活性氧的检测和解毒以及仿生催化。此外，晚上举行的两次海报会议将允许所有与会者为这些主题的讨论做出贡献。金属离子在超过三分之一的酶中发挥着关键作用，并参与许多重要的生物合成途径，包括电化学能到化学能的转化，以及抗生素、DNA、神经递质、类固醇、白三烯和激素的生物合成。 有关金属酶功能的分子水平细节来自于化学、生物学和物理学交叉领域的几个互补的研究领域。 与 MIB GRC 会议相关的正式和非正式讨论对于该领域的进步以及促进这一高度跨学科研究领域的合作至关重要。