Mount Sinai Institutes for Clinical and Translational Sciences

西奈山临床和转化科学研究所

• 批准号: 7892500
• 负责人: Hugh A Sampson
• 金额: $ 627.85万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-14 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7892500
• 关键词: Caregivers; Clinical; Clinical Investigator; Clinical Research; Clinical Trials; Clinical Trials Design; Collaborations; Communities; Consultations; Country; Development; Environment; Fostering; Future; General Population; Goals; Grant; Health Benefit; Health Professional; Home environment; Hospitals; Information Networks; Institutes; Institution; Instruction; Laboratories; Mentors; Methodology; Participant; Patients; Procedures; Recruitment Activity; Research; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Resources; Rewards; Scientific Advances and Accomplishments; Scientist; Structure; Technology; Therapeutic; Training; Training Support; Translating; Translational Research; Translations; bench to bedside; career development; clinical practice; improved; interdisciplinary collaboration; medical schools; multidisciplinary; novel; programs; standard of care

Despite great scientific advances over the past decade, the translation of these discoveries to the benefit of patients has been hampered by a number of traditional barriers. The overall goal of the Mount Sinai institutes of Clinical & Translational Sciences is to establish a new research paradigm at Mount Sinai, which will create an integrated multidisciplinary environment that will enable translation of cutting-edge research more quickly and easily from "bench-to-bedside-to-implementation" in the community; train and create an "academic home" for the clinical and translational investigators of tomorrow; and supply the governance, facilities, resources and opportunities needed to elevate the clinical research enterprise so that clinical investigators can take full advantage of Mount Sinai's Translational Research Institutes and potential collaborators in Mount Sinai Hospital and its affiliates, the School of Medicine and partnering institutions, and other CTSA programs around the country. This transformation will be achieved by fulfilling the following Specific Aims: (1) redesign the institutional research enterprise infrastructure and governance by integrating research functions across administrative, departmental and intellectual boundaries, enhancing and promoting interactions between basic scientists and clinical investigators, and streamlining administrative procedures to facilitate the start-up of clinical trials and the dissemination of results; (2) establish a Translational Discoveries Program to facilitate and expedite clinical research by providing consultation, oversight and facilities for clinical and translational research, engaging the surrounding community and our affiliates to rapidly translate health benefits to the general population, and developing new methodologies to improve clinical trial design and reduce participant burden; (3) train and support the translational investigators of tomorrow by overseeing a multi-disciplinary, doctoral degree-granting program in clinical and translational research for all health care professionals, developing a program to recruit, enhance career development and retain clinical and translational researchers, providing an academic home where new collaborations can be formulated; (4) establish an Experimental Therapeutics& Technologies Program to stimulate the development of new methodologies in clinical and translational research by developing an institution-wide mentored program to identify and develop novel clinical and translational research projects; and (5) establish an institution-wide biomedical information infrastructure that can connect basic researchers, clinical researchers, caregivers and laboratories with an integrated network of information. RELEVANCE (See instructions): The establishment ofthe Mount Sinai Institutes of Clinical & Translational Sciences would create an effective, efficient and centralized research administrative structure, foster and reward interdisciplinary collaborations, educate and retain the clinical and translational investigators of the future, enable translation of basic scientific discoveries into clinical practice, and deliver to our diverse community new therapies and a standard of care that would have been unimaginable even five years ago.

尽管过去十年的科学进步巨大，但这些发现的翻译为有益 患者受到许多传统障碍的阻碍。西奈山的总体目标 临床和转化科学学院是在西奈山建立新的研究范式 这将创建一个综合的多学科环境，该环境将使尖端翻译 从社区中的“卧铺到卧铺”更快，更容易地研究；火车和 为明天的临床和翻译调查员创建一个“学术住所”；并提供 提升临床研究企业所需的治理，设施，资源和机会，以便 临床研究人员可以充分利用西奈山的翻译研究所和潜力 西奈山医院及其分支机构，医学院和合作机构的合作者以及 全国其他CTSA计划。通过实现以下内容，将实现这种转变 具体目的：（1）通过整合来重新设计机构研究企业基础设施和治理 跨行政，部门和智力界限的研究功能，增强和 促进基本科学家与临床研究人员之间的互动，并简化行政 促进临床试验启动和结果传播的程序； （2）建立 翻译发现计划，以提供咨询，以促进和加快临床研究， 临床和转化研究的监督和设施，吸引周围社区和我们的 分支机构将健康福利迅速转化为一般人群，并将新方法发展为 改善临床试验设计并减轻参与者负担； （3）训练和支持翻译 明天的调查人员通过监督临床和 所有医疗保健专业人员的翻译研究，制定招聘计划，增强职业 开发和保留临床和转化研究人员，提供了一个新的学术室 可以制定合作； （4）建立一个实验治疗和技术计划 通过开发一种 机构范围内的指导计划，以识别和开发新颖的临床和翻译研究项目； （5）建立一个范围内机构的生物医学信息基础架构，该基础架构可以连接基础研究人员， 具有综合信息网络的临床研究人员，护理人员和实验室。 相关性（请参阅说明）： 西奈山临床和转化科学学院的建立将创造一个 有效，高效和集中的研究行政结构，促进和奖励跨学科 合作，教育和保留未来的临床和翻译调查员，启用翻译 临床实践中的基本科学发现，并将其提供给我们多样化的社区新疗法和 即使五年前，也无法想象的护理标准。