New Approaches to Assess and Forestall Osteoarthritis in Injured Joints

评估和预防受伤关节骨关节炎的新方法

• 批准号: 7677869
• 负责人: JOSEPH A. BUCKWALTER
• 金额: $ 148.81万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-10 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7677869
• 关键词: New; Approaches; Assess; Forestall; Osteoarthritis

DESCRIPTION (provided by applicant): The goal of the University of Iowa CORT is to develop new methods of forestalling post-traumatic osteoarthritis (PTOA) through a multi-disciplinary translational approach including basic science, bioengineering, imaging, and clinical research. The central theme is that joint injuries initiate a sequence of biologic events that lead to PTOA and that new treatments of joint injuries will minimize these deleterious events and promote joint healing. The specific aims are to: 1) advance understanding of the pathogenesis of PTOA, 2) develop and refine reliable quantitative measures of severity of joint injuries, including measures of structural damage and biologic response to joint injury, and 3) apply the advances in understanding of the pathogenesis of PTOA and assessment of joint injury to new methods of forestalling PTOA. The four CORT projects are: 1. Cartilage Extracellular Matrix Fragments and Trauma-Induced Chondrolysis, an in vitro study that will identify pathways responsible for propagation of cell damage following injury; 2. Acute versus Chronic Mechanical Damage in the Etiology of PTOA, an experimental study that will define the role of loading of injured joints in causing OA, and new methods for preventing OA in injured joints; 3. Validation and Application of MRI Biomarkers in Assessing Articular Cartilage Health, a clinical and experimental study of non-fracture cartilage injury that will help define the ability of non-invasive measures to assess the severity of cartilage damage, that will identify which synovial fluid markers of acute joint injury reflect that damage, and that will test the hypothesis that decreased loading accelerates restoration of injured joint surfaces; and 4. Quantifying Injury Severity to Assess the Risk for Post-Traumatic OA, a clinical study of intra-articular fractures that will examine the hypothesis that new quantitative measures of the severity of structural joint injury predict clinical outcomes. This project also will conduct a multi-center study of the severity of joint injury, in preparation for clinical trials of molecular interventions to minimize the risk of OA following joint injury. The four projects will be supported by an administrative-biostatistics core, a biomechanics-imaging core, and a tissue and experimental modeling core. Relevance to Public Health: Osteoarthritis (OA) is the most common joint disease and is among the most important causes of pain, disability, and economic loss. About 12% of OA arises following joint trauma. The risk of OA ranges from 20% to 50% or more following many common joint injuries; and, despite evolving surgical methods of treating joint injuries, this risk has not decreased appreciably in the last 20 years. The basic science, bioengineering and clinical research in this CORT will lead to new biologic and improved minimally invasive operative treatments of joint injury that will forestall OA and thereby improve the lives of hundreds of thousands of people.

描述（由申请人提供）：爱荷华大学科特大学的目标是通过多学科翻译方法（包括基础科学，生物工程，成像，成像和临床研究）开发新的阻止创伤后骨关节炎（PTOA）的方法。中心主题是，联合伤害引发了一系列生物事件，这些事件导致PTOA，新的关节损伤治疗将使这些有害事件最小化并促进关节愈合。具体目的是：1）提前了解PTOA的发病机理，2）开发和完善可靠的关节损伤严重程度的定量定量测量，包括对关节损伤的结构损害和生物学反应的度量，以及3）在了解PTOA的病原体以及对新方法的关节损伤的情况下，将其应用进展。四个CORT项目是：1。软骨细胞外基质片段和创伤引起的软骨溶解，这是一项体外研究，该研究将确定负责损伤后细胞损伤传播的途径； 2。PTOA病因中的急性与慢性机械损伤，这项实验研究将定义受伤关节在引起OA中的负载的作用，以及防止受伤关节中OA的新方法； 3。MRI生物标志物在评估关节软骨健康中的验证和应用，这是对非骨折软骨损伤的临床和实验研究4。量化损伤严重程度以评估创伤后OA的风险，这是对关节内骨折的临床研究，该研究将研究以下假设：结构性关节损伤严重程度的新定量测量可以预测临床结果。该项目还将对关节损伤的严重程度进行多中心研究，以准备分子干预的临床试验，以最大程度地减少关节损伤后OA的风险。这四个项目将由行政生物统计学核心，生物力学成像核心以及组织和实验建模核心提供支持。 与公共卫生有关：骨关节炎（OA）是最常见的关节疾病，是疼痛，残疾和经济损失的最重要原因之一。联合创伤后约有12％的OA出现。在许多常见的联合伤害之后，OA的风险范围从20％到50％或更多。而且，尽管进化于治疗关节损伤的手术方法，但在过去的20年中，这种风险并未明显降低。该Cort的基础科学，生物工程和临床研究将导致新的生物学和改进的关节损伤的最低侵入性手术治疗方法，从而可以阻止OA，从而改善成千上万人的生活。