Training in Environmental Pathology

环境病理学培训

• 批准号: 7232887
• 负责人: Agnes B Kane
• 金额: $ 23.68万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7232887
• 关键词: Pathology; Training

DESCRIPTION (provided by applicant) The objective of this predoctoral and postdoctoral training program is to educate a new generation of environmental pathologists to use the tools of cell biology, molecular biology, and biochemistry to study basic mechanisms of disease related to environmental exposures. The central focus is an independent laboratory research project to explore the pathogenesis of altered reproductive function, adverse developmental and pregnancy outcomes, neurodegenerative disease, or cancer resulting from exposure to industrial wastes and environmental contaminants including metals, plasticizers, pesticide, particulates and fibers. Predoctoral trainees will be recruited with majors in biology, chemistry, toxicology, or environmental sciences and a commitment to basic research on mechanism of disease and environmental health. Postdoctoral trainees may hold a doctoral degree in a basic science discipline, pathology, or toxicology. All predoctoral trainees are required to learn the basic mechanisms and morphologic manifestations of human disease. Training is also required to learn the basic mechanisms and morphologic manifestations of human disease. Training is also provided in molecular pathology, imaging, and environmental toxicology, signal transduction, carcinogenesis, and molecular genetics. All trainees will be instructed in the responsible conduct of research and will have the opportunity to develop their communication and teaching skills at the Sheridan Center for Teaching and Learning at Brown University. Didactic courses are supplemented by weekly research seminars, student journal clubs, career development workshops, and an annual Environmental Pathology Symposium, Strong emphasis is placed on communication skills, grantsmanship, interdisciplinary approaches, and implications of basic research for recognition and prevention of human disease. Opportunities are provided for clinical and translational research collaborations at Rhode Island Hospital and Women & Infants' Hospital, as well as field work and community outreach at existing industrial waste sites and Brownfields in Rhode Island. The eight faculty have active, well-funded research programs ($4.4 million in annual direct costs) and access to modern research facilities equipped for quantitative imaging, laser capture microdissection, genomics and proteomics, flow cytometry, transgenic animals, and access to human tissue and specimen banks. These trainees will be prepared to apply their basic research expertise to the definition, analysis, and solution of complex environmental health problems working together with experts in epidemiology, toxicology, public health, and government and regulatory agencies. BACKGROUND This Training in Environmental Pathology program is in its 14th year of support and is centered in the department of Pathology and Laboratory Medicine in the Division of Biology and Medicine at Brown University. The program enlists eight faculty, five of which are physicians, as mentors that have environmental related research in the areas of pulmonary, hepatic, reproductive and neurological health. The research focuses on mechanistic, translational and public health outcomes from environmental agents and common cofactors. Dr. Agnes Kane MD/PhD has acted as Director of the program since its inception and the Co-Director is Dr. Kim Boekelheide MD/PhD. The application requests funding for five predoctoral and two postdoctoral positions. Recruitment of a new Dean in 2005 with a strong mandate to improve graduate education in the Division of Biology and Medicine was considered an advantageous asset to the Environmental Pathology Training Program. In 2006 the Training Program recruited its largest applicant pool. It was noteworthy that the program has over $4 million in direct cost funding. A major change in the predoctoral curriculum was a reduction in the number of required courses and seminars and transfer of the first research rotation to the first semester. This change was considered to facilitate the trainee's selection of a thesis research mentor at the end of the second semester and to facilitate the trainee's progression to completion of the preliminary examination at the end of the second year. The program has multiple interactive activities with trainees to address the responsible conduct of research. In response to feedback received via internal and external reviews the number of invited speakers representing diverse career pathways has been increased. This application seeks continuing support (years 16-20) for training in the environmental pathology track within the Pathobiology Graduate Program at Brown University. This program is part of the Division of Biology and Medicine and Center for Environmental Studies. Eight preceptors are named in the renewal application, down from ten named in 2001.

描述（由申请人提供） 该博士前和博士后培训项目的目的是教育新一代环境病理学家使用细胞生物学、分子生物学和生物化学的工具来研究与环境暴露相关的疾病的基本机制。 中心重点是一个独立的实验室研究项目，旨在探索由于接触工业废物和环境污染物（包括金属、增塑剂、农药、颗粒物和纤维）而导致的生殖功能改变、不良发育和妊娠结局、神经退行性疾病或癌症的发病机制。 招收生物学、化学、毒理学或环境科学专业的博士前培训生，致力于疾病与环境健康机制的基础研究。 博士后培训生可以拥有基础科学学科、病理学或毒理学博士学位。 所有博士前学员都需要学习人类疾病的基本机制和形态表现。 还需要培训来了解人类疾病的基本机制和形态表现。 还提供分子病理学、成像、环境毒理学、信号转导、致癌作用和分子遗传学方面的培训。 所有学员都将接受负责任地进行研究的指导，并将有机会在布朗大学谢里登教学中心发展他们的沟通和教学技能。 教学课程还辅以每周的研究研讨会、学生期刊俱乐部、职业发展研讨会和年度环境病理学研讨会，重点强调沟通技巧、资助、跨学科方法以及基础研究对识别和预防人类疾病的影响。 提供在罗德岛医院和妇婴医院进行临床和转化研究合作的机会，以及在罗德岛现有工业废物场和棕地进行实地工作和社区外展的机会。 八名教员拥有活跃的、资金充足的研究项目（每年直接费用为 440 万美元），并可使用配备定量成像、激光捕获显微切割、基因组学和蛋白质组学、流式细胞术、转基因动物以及获取人体组织和细胞的现代化研究设施。标本库。 这些学员将准备好与流行病学、毒理学、公共卫生以及政府和监管机构的专家合作，将他们的基础研究专业知识应用于复杂环境健康问题的定义、分析和解决。 背景 该环境病理学培训项目已进入第 14 个年头，以布朗大学生物和医学系病理学和实验医学系为中心。 该项目招募了八名教员，其中五名是医生，作为导师，在肺、肝、生殖和神经健康领域进行环境相关研究。 该研究重点关注环境因素和常见辅助因子的机械、转化和公共卫生结果。 自项目启动以来，Agnes Kane 博士/博士一直担任该项目的主任，联合主任是 Kim Boekelheide 博士/博士。 该申请要求为五个博士前职位和两个博士后职位提供资金。 2005 年聘请了一位新院长，其职责是改善生物学和医学系的研究生教育，这被认为是环境病理学培训计划的有利资产。 2006 年，培训计划招募了最大的申请者。 值得注意的是，该计划有超过 400 万美元的直接成本资金。 博士前课程的一个重大变化是减少了必修课程和研讨会的数量，并将第一次研究轮转转移到第一学期。 这一变化被认为是为了方便学员在第二学期末选择论文研究导师，并方便学员在第二年末完成初步考试。 该计划与学员开展多项互动活动，以解决负责任的研究行为。 为了回应通过内部和外部审查收到的反馈，代表不同职业道路的受邀演讲者数量有所增加。 该申请寻求布朗大学病理生物学研究生项目环境病理学培训的持续支持（16-20 岁）。 该计划是生物和医学部门以及环境研究中心的一部分。 更新申请中任命了 8 名导师，而 2001 年任命的有 10 名。