Tissue Core

组织核心

• 批准号: 7866587
• 负责人: BRITT-MARIE E. LJUNG
• 金额: $ 13.34万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7866587
• 关键词: Biological; Biostatistics Core; Classification; Comprehensive Cancer Center; Fresh Tissue; Goals; Human Resources; Image; Immunohistochemistry; Mammary Gland Parenchyma; Mammographic Density; Pathologist; Process; Program Research Project Grants; Research Design; Research Personnel; Sampling; Services; Staining method; Stains; Statistical Data Interpretation; Time; Tissue Donors; Tissues; base; breast density; cancer risk; density; human tissue; insight; malignant breast neoplasm; molecular marker; molecular pathology; programs; tissue processing; Biological; Biostatistics Core; Classification; Comprehensive Cancer Center; Fresh Tissue; Goals; Human Resources; Image; Immunohistochemistry; Mammary Gland Parenchyma; Mammographic Density; Pathologist; Process; Program Research Project Grants; Research Design; Research Personnel; Sampling; Services; Staining method; Stains; Statistical Data Interpretation; Time; Tissue Donors; Tissues; base; breast density; cancer risk; density; human tissue; insight; malignant breast neoplasm; molecular marker; molecular pathology; programs; tissue processing

Mammographic breast density is a strong predictor of breast cancer risk. At this present time, little is known about which attribute(s) of mammographic density also contributes to breast cancer risk. To gain insight into this question this Program Project Grant seeks to use human tissue to explore the biologic connection between mammographic density and molecular markers for breast cancer risk. To accomplish these goals, the Core will provide services that are fundamental to all projects within the Program Project Grant application. The primary goals of the Tissue and Biostatistics Core are to process breast tissue for study by the Program Project Investigators and provide high quality characterization and biostatistical analysis of samples. Core personnel will process fresh tissue from donors in a systematic manner, which will allow correlation of tissue blocks with density images for Projects 1 and 2. The Core will coordinate routine tissue processing, embedding, sectioning and staining through the UCSF Comprehensive Cancer Center Tissue Core. Routine immunohistochemistry stains for Projects 2 and 3 will be coordinated though the UCSF Comprehensive Cancer Center Immunohistochemistry and Molecular Pathology Core. Core pathologists will be responsible for the interpretation of H&E sections and immunohistochemistry stains. The Core biostatistician will be involved in study design and statistical analyses of data obtained by Projects 1, 2, 3, and 4.

乳腺乳房乳房密度是乳腺癌风险的有力预测指标。目前，鲜为人知 乳房X线学密度的哪种属性也有助于乳腺癌的风险。获得见识 在这个问题中，这个计划项目赠款试图使用人体组织探索生物学联系 在乳腺癌风险的乳腺X线摄影密度和分子标记之间。为了实现这些目标， 核心将提供对计划项目赠款中所有项目至关重要的服务 应用。 组织和生物统计学核心的主要目标是处理乳房组织以进行研究 计划项目调查人员，并提供高质量的表征和生物统计分析 样品。核心人员将以系统的方式从捐助者那里处理新鲜组织，这将允许 组织块与项目1和2的密度图像的相关性。核心将协调常规组织 通过UCSF综合癌症中心组织加工，嵌入，切片和染色 核。项目2和3的常规免疫组织化学污渍将通过UCSF协调 综合癌症中心免疫组织化学和分子病理核心。核心病理学家 将负责H＆E部分的解释和免疫组织化学污渍。核心 生物统计学家将参与研究设计和项目1、2、3， 和4。