fMRI and DTI in Children with PVH/PVL

PVH/PVL 儿童的 fMRI 和 DTI

• 批准号: 7874622
• 负责人: Heidi M. Feldman
• 金额: $ 35.87万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-25 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7874622
• 关键词: 14 year old; Adolescent; Affect; Age; Anisotropy; Axon; Behavior; Behavioral; Brain; Brain Injuries; Brain imaging; Brain region; Case Study; Cessation of life; Child; Cognitive; Cognitive deficits; Communication; Complement; Complex; Comprehension; Control Groups; Cyst; Development; Diffusion; Diffusion Magnetic Resonance Imaging; Dorsal; Fiber; Functional Magnetic Resonance Imaging; Gender; Goals; Hemorrhage; Hypoxia; Image; Imaging Techniques; Individual; Infant; Infarction; Inflammation; Injury; Lateral; Lead; Learning; Lesion; Linguistics; Link; Magnetic Resonance; Measures; Memory; Methods; Modeling; Necrosis; Neurocognitive; Neurodevelopmental Disability; Oligodendroglia; Outcome; Parietal; Participant; Pathway interactions; Pattern; Performance; Periventricular Leukomalacia; Physiological; Premature Birth; Process; Reaction Time; Regression Analysis; Research Personnel; Risk; Saccades; Short-Term Memory; Socioeconomic Status; Structure; Testing; Venous; base; behavior measurement; behavior test; cognitive function; comparison group; frontal lobe function; gray matter; injured; language processing; lateral ventricle; myelination; neural circuit; neural patterning; oculomotor; relating to nervous system; response; skills; white matter; white matter damage; white matter injury

DESCRIPTION (provided by applicant): Children born prematurely are at risk for Periventricular Hemorrhage (PVH) and Periventricular Leukomalacia (PVL), lesions which lead to unilateral and multi-focal white matter damage, respectively. Children with PVH and PVL are at risk for neurodevelopmental disabilities. The goal of this study is to relate the degree and patterns of white matter damage from PVH and PVL to linguistic and cognitive outcomes. Two sophisticated MRI procedures will complement behavioral testing. Diffusion Tensor Imaging (DTI) provides detailed voxel-based quantitative information on the integrity of white matter microstructure; functional Magnetic Resonance Imaging (fMRI) characterizes the patterns of neural activity underlying cognitive skills. fMRI tasks will assess domains known to be supported in mature functioning by widely distributed brain circuitry that may be impaired after white matter injury-comprehension of syntactically complex sentences, which relies on interhemispheric integration, and oculomotor response inhibition and spatial working memory, which rely on occipital-frontal and cortical-subcortical integration. The combination of methods will allow us to link brain structure, brain functioning, and behavioral outcomes. Participants will be 40 adolescents, 9 to 14 years old, with PVH or PVL from preterm delivery. Two control groups (children born prematurely and children born at term) matched for age, gender and socioeconomic status (SES) will clarify the contribution of white matter damage versus other influences, such as age and premature delivery, on outcomes. Regression analyses will evaluate the associations of global and track-specific white matter damage and behavioral outcomes. Models will also consider the contributions of age, gender, SES, and extent of gray matter injury to white matter integrity and outcomes. Patterns of activation on fMRI will be evaluated in relation to the extent and pattern of white matter damage and to scores on the behavioral measures. We will identify cases that reveal important relations between neural structure and function. This study will contribute to understanding the outcomes of PVH and PVL, an important issue because of the large number of affected infants. It will contribute to understanding the importance of white matter connections in the normal development of cognitive processes. It will also contribute to understanding the impact of white matter injury and the development of cortical plasticity after early brain injuries.

描述（由申请人提供）：早产儿有脑室周围出血（PVH）和脑室周围白质软化（PVL）的风险，这两种病变分别导致单侧和多灶性白质损伤。患有 PVH 和 PVL 的儿童有神经发育障碍的风险。本研究的目的是将 PVH 和 PVL 造成的白质损伤的程度和模式与语言和认知结果联系起来。两种复杂的 MRI 程序将补充行为测试。扩散张量成像 (DTI) 提供有关白质微结构完整性的详细的基于体素的定量信息；功能性磁共振成像 (fMRI) 表征了认知技能背后的神经活动模式。功能磁共振成像任务将评估已知由广泛分布的脑回路支持成熟功能的领域，这些脑回路在白质损伤后可能会受损——对句法复杂句子的理解，依赖于大脑半球间的整合，以及动眼反应抑制和空间工作记忆，这依赖于大脑半球间的整合。枕叶-额叶和皮质-皮质下整合。方法的结合将使我们能够将大脑结构、大脑功能和行为结果联系起来。参与者将是 40 名 9 至 14 岁的青少年，患有早产儿 PVH 或 PVL。年龄、性别和社会经济地位 (SES) 匹配的两个对照组（早产儿和足月儿）将阐明白质损伤与其他影响（例如年龄和早产）对结果的影响。回归分析将评估全局和特定轨迹白质损伤与行为结果的关联。模型还将考虑年龄、性别、社会经济地位和灰质损伤程度对白质完整性和结果的影响。将根据白质损伤的程度和模式以及行为测量的分数来评估功能磁共振成像的激活模式。我们将识别揭示神经结构和功能之间重要关系的案例。这项研究将有助于了解 PVH 和 PVL 的结果，由于受影响的婴儿数量众多，这是一个重要问题。它将有助于理解白质连接在认知过程正常发展中的重要性。它还将有助于了解白质损伤的影响以及早期脑损伤后皮质可塑性的发展。

项目成果

Language and reading skills in school-aged children and adolescents born preterm are associated with white matter properties on diffusion tensor imaging.

• DOI: 10.1016/j.neuropsychologia.2012.10.014
• 发表时间: 2012-12
• 期刊: Neuropsychologia
• 影响因子: 2.6
• 作者: Feldman HM;Lee ES;Yeatman JD;Yeom KW
• 通讯作者: Yeom KW

Case series: fractional anisotropy along the trajectory of selected white matter tracts in adolescents born preterm with ventricular dilation.

• DOI: 10.1177/0883073812449693
• 发表时间: 2013-06
• 期刊: Journal of child neurology
• 影响因子: 1.9
• 作者: Myall NJ;Yeom KW;Yeatman JD;Gaman-Bean S;Feldman HM
• 通讯作者: Feldman HM

Case Series: Fractional Anisotropy Profiles of the Cerebellar Peduncles in Adolescents Born Preterm With Ventricular Dilation.

病例系列：早产儿心室扩张青少年小脑脚的分数各向异性轮廓。

• DOI: 10.1177/0883073815592223
• 发表时间: 2016
• 期刊: Journal of child neurology
• 影响因子: 1.9
• 作者: Travis,KatherineE;Leitner,Yael;Ben-Shachar,Michal;Yeom,KristenW;Feldman,HeidiM
• 通讯作者: Feldman,HeidiM

Decreased and Increased Anisotropy along Major Cerebral White Matter Tracts in Preterm Children and Adolescents.

早产儿和青少年主要大脑白质束各向异性的减少和增加。

• DOI: 10.1371/journal.pone.0142860
• 发表时间: 2015
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Travis,KatherineE;Adams,JennaN;Ben-Shachar,Michal;Feldman,HeidiM
• 通讯作者: Feldman,HeidiM

Executive function skills are associated with reading and parent-rated child function in children born prematurely.

执行功能技能与早产儿的阅读和父母评价的儿童功能有关。

• DOI: 10.1016/j.earlhumdev.2011.07.018
• 发表时间: 2012
• 期刊: Early human development
• 影响因子: 2.5
• 作者: Loe,IreneM;Lee,ElianaS;Luna,Beatriz;Feldman,HeidiM
• 通讯作者: Feldman,HeidiM