Core--Informatics and statistical genetics

核心--信息学和统计遗传学

• 批准号: 7844962
• 负责人: NICHOLAS Joseph SCHORK
• 金额: $ 24.11万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7844962
• 关键词: Area; Biochemistry; Bioinformatics; Biological Assay; Blood Pressure; Computational Biology; Computer Simulation; Data Analyses; Databases; Development; Docking; Experimental Designs; Genes; Genetic; Genetic Polymorphism; Genomics; Genotype; Haplotypes; Human; Individual; Informatics; Maps; Methodology; Methods; Molecular; Nature; Neuroeffector Junction; Operative Surgical Procedures; Phenotype; Polymorphism Analysis; Population Genetics; Program Research Project Grants; Proteins; Research; Research Personnel; Research Project Grants; Sampling; Sampling Studies; Sequence Analysis; Stratification; Twin Multiple Birth; assay development; design; human subject; mathematical model; member; novel; research study; web site

The Informatics and Statistical Genetics Core (ISGC) of the Program Project Grant (PPG) research will provide novel methodological developments and guidance in a number of areas of relevance to bioinformatics, computational biology, mathematical modeling, data analysis, and population genetics aspects of the PPG. The ISGC researchers will include members of the research teams involved in the 6 applied projects associated with the Consortium as well as additional Consortium members. The specific aims of the ISGC are to: Provide applied bioinformatics and sequence analysis support to he PPG in conjunction with the Molecular Genomics Core (MGC), by overseeing and implementing a variety of operations, e.g., database searches for polymorphism information, flanking sequence identification for genotyping assay development, homology searches for novel sequence findings, evolutionary analysis of sequence information, etc. Provide computational biology support and in silico analysis of polymorphism in the genes chosen for study. These activities include mapping non-synonymous cSNPs onto proteins, where appropriate, and assessing protein interactions via docking experiments, as well as maintaining a WEB site supplying relevant information detailing these activities in order to serve the PPG research broadly. Provide data analysis support and, in particular, novel data analysis methodology development in areas such as haplotype analysis, epistatic interaction analysis, twin analysis, etc. Provide design, oversight, and interpretation of population genetic assays, most notably those used to assess potential genetic stratification and cryptic sample substructure with the study samples. Although we detail activities of the ISGC below, we want to emphasize that some information provided by the ISGC, as well as additional information of relevance to the ISGC, has been integrated into the descriptions of the MGC, the Human Phenotyping/twins Core, the Biochemistry Core, the Administrative Core (AC), as well as the 6 individual research projects. Given page limitations and the nature of the ISGC activities, we have combined the Preliminary Studies and Experimental Design and Methods Sections (sections C and D) and focus on organization in section B, below, and omit sections on Human Subjects, etc. normally at the end of the proposal.

计划项目赠款（PPG）研究的信息学和统计遗传学核心（ISGC）将在与生物信息学，计算生物学，数学建模，数据分析和人群遗传学方面相关的许多领域提供新的方法论发展和指导。 ISGC研究人员将包括与财团相关的6个应用项目的研究团队的成员以及其他财团成员。 ISGC的具体目的是：通过监督和实施各种操作，例如，通过分子基因组学核心（MGC）提供应用的生物信息学和序列分析支持，例如分子基因组学核心（MGC）。 数据库搜索基因分型测定开发的多态性信息，侧翼序列鉴定，同源性搜索新型序列发现，序列信息的进化分析等。提供计算生物学支持以及在选择用于研究基因的多态性的计算机分析中。这些活动包括在适当的情况下将非同义性CSNP映射到蛋白质上，并通过对接实验评估蛋白质相互作用，以及维护提供相关信息的网站，以详细介绍这些活动，以便广泛地为PPG研究提供服务。提供数据分析支持，尤其是新型数据分析方法论在单倍型分析，上皮相互作用分析，双分析等领域提供了对种群遗传测定的设计，监督和解释，最值得注意的是那些用于评估潜在的遗传分层和与研究样本的潜在遗传分层和隐性样本子结构的方法。尽管我们详细介绍了下面的ISGC的活动，但我们要强调，ISGC提供的一些信息以及与ISGC相关的其他信息已集成到MGC的描述中，人类表型/双胞胎核心，生物化学核心，生物化学核心，行政核心（AC）以及6个个人研究项目。给定页面限制和ISGC活动的性质，我们将初步研究和实验设计和方法组合在一起（C和D节），并关注B节中的组织，并在下面的Bection中进行组织，并省略了有关人类受试者等部分等。通常在提案结束时。