Core--Informatics and statistical genetics

核心--信息学和统计遗传学

• 批准号: 7844962
• 负责人: NICHOLAS Joseph SCHORK
• 金额: $ 24.11万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7844962
• 关键词: Area; Biochemistry; Bioinformatics; Biological Assay; Blood Pressure; Computational Biology; Computer Simulation; Data Analyses; Databases; Development; Docking; Experimental Designs; Genes; Genetic; Genetic Polymorphism; Genomics; Genotype; Haplotypes; Human; Individual; Informatics; Maps; Methodology; Methods; Molecular; Nature; Neuroeffector Junction; Operative Surgical Procedures; Phenotype; Polymorphism Analysis; Population Genetics; Program Research Project Grants; Proteins; Research; Research Personnel; Research Project Grants; Sampling; Sampling Studies; Sequence Analysis; Stratification; Twin Multiple Birth; assay development; design; human subject; mathematical model; member; novel; research study; web site

The Informatics and Statistical Genetics Core (ISGC) of the Program Project Grant (PPG) research will provide novel methodological developments and guidance in a number of areas of relevance to bioinformatics, computational biology, mathematical modeling, data analysis, and population genetics aspects of the PPG. The ISGC researchers will include members of the research teams involved in the 6 applied projects associated with the Consortium as well as additional Consortium members. The specific aims of the ISGC are to: Provide applied bioinformatics and sequence analysis support to he PPG in conjunction with the Molecular Genomics Core (MGC), by overseeing and implementing a variety of operations, e.g., database searches for polymorphism information, flanking sequence identification for genotyping assay development, homology searches for novel sequence findings, evolutionary analysis of sequence information, etc. Provide computational biology support and in silico analysis of polymorphism in the genes chosen for study. These activities include mapping non-synonymous cSNPs onto proteins, where appropriate, and assessing protein interactions via docking experiments, as well as maintaining a WEB site supplying relevant information detailing these activities in order to serve the PPG research broadly. Provide data analysis support and, in particular, novel data analysis methodology development in areas such as haplotype analysis, epistatic interaction analysis, twin analysis, etc. Provide design, oversight, and interpretation of population genetic assays, most notably those used to assess potential genetic stratification and cryptic sample substructure with the study samples. Although we detail activities of the ISGC below, we want to emphasize that some information provided by the ISGC, as well as additional information of relevance to the ISGC, has been integrated into the descriptions of the MGC, the Human Phenotyping/twins Core, the Biochemistry Core, the Administrative Core (AC), as well as the 6 individual research projects. Given page limitations and the nature of the ISGC activities, we have combined the Preliminary Studies and Experimental Design and Methods Sections (sections C and D) and focus on organization in section B, below, and omit sections on Human Subjects, etc. normally at the end of the proposal.

计划项目拨款（PPG）研究的信息学和统计遗传学核心（ISGC）将为与生物信息学、计算生物学、数学建模、数据分析和群体遗传学方面相关的许多领域提供新颖的方法学发展和指导。 PPG。 ISGC研究人员将包括参与与联盟相关的6个应用项目的研究团队成员以及其他联盟成员。 ISGC 的具体目标是： 通过监督和实施各种操作，结合分子基因组学核心 (MGC) 向 PPG 提供应用生物信息学和序列分析支持，例如， 数据库搜索多态性信息、用于基因分型测定开发的侧翼序列鉴定、新序列发现的同源性搜索、序列信息的进化分析等。提供计算生物学支持以及对所选研究基因的多态性进行计算机分析。这些活动包括在适当的情况下将非同义 cSNP 映射到蛋白质上，通过对接实验评估蛋白质相互作用，以及维护提供详细说明这些活动的相关信息的网站，以便广泛服务于 PPG 研究。提供数据分析支持，特别是在单倍型分析、上位相互作用分析、双胞胎分析等领域提供新颖的数据分析方法开发。提供群体遗传分析的设计、监督和解释，尤其是那些用于评估潜在遗传的分析研究样本的分层和神秘样本子结构。尽管我们在下面详细介绍了 ISGC 的活动，但我们要强调的是，ISGC 提供的一些信息以及与 ISGC 相关的其他信息已纳入 MGC、人类表型/双胞胎核心、生物化学核心、行政核心 (AC) 以及 6 个单独的研究项目。鉴于页面限制和 ISGC 活动的性质，我们合并了初步研究和实验设计和方法部分（C 和 D 部分），并重点关注下面 B 部分的组织，并省略了有关人类受试者等的部分。提案结束。