Leptin Transport across the BBB: The Role of ObR (+) astrocytes

瘦素跨 BBB 运输：ObR ( ) 星形胶质细胞的作用

• 批准号: 8074152
• 负责人: ABBA J KASTIN
• 金额: $ 22.2万
• 依托单位: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-05 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8074152
• 关键词: Address; Adipocytes; Adipose tissue; Adult; Affect; Albumins; Animals; Apical; Astrocytes; Biological Assay; Blood; Blood - brain barrier anatomy; Brain; Cardiovascular system; Cell Communication; Cells; Cerebrum; Chemicals; Coculture Techniques; D Glutamate; Data; Degradation Pathway; Dextrans; Diet; Diffusion; Effector Cell; Endocytosis; Endosomes; Endothelial Cells; Exocytosis; Fatty acid glycerol esters; Generations; Golgi Apparatus; Grant; Half-Life; High Pressure Liquid Chromatography; Homeostasis; Hormones; Hyperlipidemia; Hypothalamic structure; In Vitro; Injection of therapeutic agent; Kinetics; Knockout Mice; Label; Laboratories; Leptin; Link; Location; Lysosomes; Membrane; Messenger RNA; Metabolic; Metabolic syndrome; Modeling; Morbid Obesity; Mus; Mutation; Neurons; Neurosecretory Systems; Nutrient; Obesity; Paper; Pathway interactions; Permeability; Phenotype; Play; Prevalence; Process; Proteins; Recycling; Regulation; Reporting; Role; Series; Serine; Side; Signal Transduction; Sleep Apnea Syndromes; Specificity; System; Testing; Tight Junctions; Time; Tissues; Up-Regulation; Work; abstracting; adipokines; astrogliosis; cancer complication; combat; dextran; fluorocitrate; immunocytochemistry; in vitro Model; in vivo; inhibitor/antagonist; leptin receptor; monolayer; mouse model; multicatalytic endopeptidase complex; mutant; new therapeutic target; novel; overexpression; public health relevance; receptor; response; uptake