Superfund Chemical Impact on Development

超级基金对发展的化学影响

• 批准号: 7434532
• 负责人: Richard Di Giulio
• 金额: $ 256.08万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7434532
• 关键词: Superfund; Chemical; Impact; Development

DESCRIPTION (provided by applicant) The major theme of this proposed Superfund Hazardous Substances Basic Research Program is the elucidation of mechanisms of exposure and toxicity in humans and ecosystems to particular Superfund chemicals selected based upon their potential significance with respect to developmental effects. The major goals of the Program are as follows: 1) to elucidate mechanisms of developmental toxicity of selected Superfund chemicals and chemical mixtures; 2) to facilitate the transfer of mechanistic information obtained across selected invertebrate and vertebrate models relevant to human and/or ecological health; 3) to utilize microarray approaches for assessing gene expression during normal and perturbed development in our models, and enhance the genomic database for these models; 4) to develop highly sensitive and efficient markers for developmental toxicities that can be incorporated into human health and ecological assessments; 5) to elucidate microbial and photolytic transformations of selected Superfund chemicals that augment their environmental fate and effects upon development; 6) to use Geographic Information Systems (GIS) spatial analysis to develop and disseminate preventive risk models for environmental health in North Carolina, with an emphasis on children; 7) to effectively deliver the Program's research results to critical members of the scientific, governmental, business and lay communities; and 8) to enhance interdisciplinary research, and graduate and post-graduate training, in the biomedical and environmental sciences.

描述（由申请人提供） 该提出的超级基金危险物质基础研究计划的主要主题是阐明人类和生态系统中对特定超级基金化学物质的暴露和毒性机制，基于其对发育效果的潜在意义。该计划的主要目标如下：1）阐明选定超级基金化学物质和化学混合物的发育毒性机制； 2）促进与人类和/或生态健康相关的某些无脊椎动物和脊椎动物模型中获得的机械信息的传递； 3）利用微阵列方法来评估我们模型正常和扰动发育过程中基因表达，并增强这些模型的基因组数据库； 4）为发育毒性开发高度敏感和有效的标志物，可以纳入人类健康和生态评估中； 5）阐明所选超基金化学物质的微生物和光解体转化，以增强其环境命运和对发展的影响； 6）使用地理信息系统（GIS）空间分析来开发和传播北卡罗来纳州环境健康的预防风险模型，重点是儿童； 7）有效地将该计划的研究成果提供给科学，政府，商业和外行社区的关键成员； 8）在生物医学和环境科学领域增强跨学科研究，研究生和研究生培训。