COREGISTRATION OF MRI/MRS AND DOS IN HUMAN SUBJECTS

人体受试者中 MRI/MRS 和 DOS 的联合配准

• 批准号: 7722525
• 负责人: ALBERT Edward CERUSSI
• 金额: $ 0.67万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-15 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7722525
• 关键词: Breast Cancer Detection; Characteristics; Clinical Management; Computer Retrieval of Information on Scientific Projects Database; Data; Depth; Diffuse; Funding; Grant; Inflammatory; Institution; Magnetic Resonance Imaging; Measurement; Necrosis; Optics; Patients; Pattern; Research; Research Personnel; Resources; Scanning; Signal Transduction; Site; Slice; Source; Spectrum Analysis; Tissues; Tumor Volume; United States National Institutes of Health; base; indexing; malignant breast neoplasm; tumor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A handheld scanning probe based on broadband Diffuse Optical Spectroscopy (DOS) was used in combination with dynamic contrast enhanced MRI (DCE-MRI) to quantitatively characterize locally-advanced breast cancers in patients. Measurements were performed sequentially using external fiducial markers for co-registration. Tumor patterns were categorized according to MRI morphological data, and 3D DCE-MRI slices were converted into a volumetric matrix with isotropic voxels to generate views that coincided with the DOS scanning plane. Tumor volume and depth at each DOS measurement site were determined, and a tissue optical index (TOI) that reflects both angiogenic and stromal characteristics was derived from broadband DOS data. Optical scans have showed significant TOI contrast corresponding to MRI morphological information. Sharp TOI peaks were recovered for well-circumscribed masses. A reduction in TOI was found inside a tumor with a necrotic center. A broadened peak was observed for a diffuse tumor pattern, and an inflammatory septal case provided two TOI peaks that correlated qualitatively with MRI enhancement. These results provide qualitative confirmation of the common signal origin and complementary information content that can be achieved by combining optical and MR imaging for breast cancer detection and clinical management.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 基于宽带漫反射光谱 (DOS) 的手持式扫描探头与动态对比增强 MRI (DCE-MRI) 相结合，定量表征患者局部晚期乳腺癌。 使用外部基准标记依次进行测量以进行共同配准。 根据 MRI 形态学数据对肿瘤模式进行分类，并将 3D DCE-MRI 切片转换为具有各向同性体素的体积矩阵，以生成与 DOS 扫描平面一致的视图。确定每个 DOS 测量部位的肿瘤体积和深度，并从宽带 DOS 数据得出反映血管生成和基质特征的组织光学指数 (TOI)。 光学扫描显示出与 MRI 形态信息相对应的显着 TOI 对比度。对于界限清楚的质量，恢复了尖锐的 TOI 峰。 在具有坏死中心的肿瘤内部发现 TOI 减少。 观察到弥漫性肿瘤模式的峰变宽，炎症性间隔病例提供了两个与 MRI 增强质量相关的 TOI 峰。这些结果提供了对共同信号​​来源和补充信息内容的定性确认，这些信息内容可以通过结合光学和磁共振成像来实现乳腺癌检测和临床管理。