COREGISTRATION OF MRI/MRS AND DOS IN HUMAN SUBJECTS

人体受试者中 MRI/MRS 和 DOS 的联合配准

• 批准号: 7722525
• 负责人: ALBERT Edward CERUSSI
• 金额: $ 0.67万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-15 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7722525
• 关键词: Breast Cancer Detection; Characteristics; Clinical Management; Computer Retrieval of Information on Scientific Projects Database; Data; Depth; Diffuse; Funding; Grant; Inflammatory; Institution; Magnetic Resonance Imaging; Measurement; Necrosis; Optics; Patients; Pattern; Research; Research Personnel; Resources; Scanning; Signal Transduction; Site; Slice; Source; Spectrum Analysis; Tissues; Tumor Volume; United States National Institutes of Health; base; indexing; malignant breast neoplasm; tumor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A handheld scanning probe based on broadband Diffuse Optical Spectroscopy (DOS) was used in combination with dynamic contrast enhanced MRI (DCE-MRI) to quantitatively characterize locally-advanced breast cancers in patients. Measurements were performed sequentially using external fiducial markers for co-registration. Tumor patterns were categorized according to MRI morphological data, and 3D DCE-MRI slices were converted into a volumetric matrix with isotropic voxels to generate views that coincided with the DOS scanning plane. Tumor volume and depth at each DOS measurement site were determined, and a tissue optical index (TOI) that reflects both angiogenic and stromal characteristics was derived from broadband DOS data. Optical scans have showed significant TOI contrast corresponding to MRI morphological information. Sharp TOI peaks were recovered for well-circumscribed masses. A reduction in TOI was found inside a tumor with a necrotic center. A broadened peak was observed for a diffuse tumor pattern, and an inflammatory septal case provided two TOI peaks that correlated qualitatively with MRI enhancement. These results provide qualitative confirmation of the common signal origin and complementary information content that can be achieved by combining optical and MR imaging for breast cancer detection and clinical management.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 使用基于宽带弥散光谱（DOS）的手持式扫描探针与动态对比度增强的MRI（DCE-MRI）结合使用，以定量地表征患者局部增强乳腺癌的表征。 使用外部基准标记依次进行测量以进行共同注册。 根据MRI形态数据对肿瘤模式进行分类，并将3D DCE-MRI切片转换为具有各向同性体素的体积基质，以生成与DOS扫描平面相吻合的视图。确定了每个DOS测量位点的肿瘤体积和深度，并从宽带DOS数据中得出了反映血管生成和基质特征的组织光学指数（TOI）。 光学扫描显示出与MRI形态信息相对应的显着TOI对比度。回收了尖锐的TOI峰，以占圆形的质量。 在具有坏死中心的肿瘤内发现TOI的降低。 观察到扩展的峰值弥散性肿瘤模式，炎症间隔病例提供了两个与MRI增强质量相关的TOI峰。这些结果提供了对共同信号​​起源和互补信息含量的定性确认，可以通过将光学和MR成像结合起来进行乳腺癌检测和临床管理来实现。