Biomagnetic Nanoparticles for Drug Delivery and Imaging

用于药物输送和成像的生物磁性纳米颗粒

• 批准号: 7436470
• 负责人: VINOD D LABHASETWAR
• 金额: $ 27.53万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7436470
• 关键词: Acute; Affect; Alloys; Animal Model; Antibodies; Antineoplastic Agents; Area; Biocompatible; Biocompatible Materials; Biodistribution; Biology; Blood Circulation; Breast; Breast Cancer Model; Caliber; Cancer cell line; Cardiovascular system; Cells; Cerebral Ischemia; Charge; Condition; Contrast Media; Coupled; Deposition; Detection; Diagnostic; Diffusion; Disease; Dissociation; Dose; Doxorubicin; Drug Carriers; Drug Combinations; Drug Delivery Systems; Drug Formulations; Early Diagnosis; Endothelial Cells; Fever; Figs - dietary; Frequencies; Funding; Gene Delivery; Goals; Half-Life; Hour; Image; Imaging Techniques; In Vitro; Laboratories; Lead; Ligands; Liquid substance; Magnetic Resonance; Magnetic Resonance Imaging; Magnetism; Malignant neoplasm of prostate; Medicine; Modeling; Modification; Monitor; Mus; Nanotechnology; Noble Gases; Oxides; Paclitaxel; Particle Size; Pathologic; Pathology; Pharmaceutical Preparations; Pharmacy (field); Phase; Physical condensation; Physics; Pilot Projects; Pluronics; Principal Investigator; Process; Property; Protocols documentation; Purpose; Radiology Specialty; Range; Rate; Reaction Time; Reagent; Research; Research Personnel; Research Project Grants; Resistance; Resolution; Reticuloendothelial System; Serum; Sorting - Cell Movement; Standards of Weights and Measures; Surface; System; Techniques; Technology; Temperature; Testing; Therapeutic; Therapeutic Effect; Time; Tissues; Water; Work; aqueous; base; bioimaging; biomaterial compatibility; cancer therapy; copolymer; desire; hyperthermia treatment; improved; intravenous administration; iron oxide; magnetic field; malignant breast neoplasm; monocyte; multidisciplinary; nanomaterials; nanometer; nanoparticle; nanoscience; nanostructured; neoplastic cell; next generation; novel; oxidation; particle; physical property; planetary Atmosphere; programs; response; size; surfactant; therapeutic effectiveness; tumor; tumor progression; uptake; vapor

The next generation of nanoparticles for biomedical uses will serve multiple functions using a single formulation: for example, magnetic nanoparticles that allow targeted drug delivery and magnetic imaging. One of the primary reasons magnetic targeting has not fulfilled its promise is that the magnetic moment of a nanoparticle decreases with size. Since the magnetic force on the particle is equal to the product of the externally applied magnetic-field gradient and particle's magnetic moment, developing nanoparticles with significantly greater moment is critical. Our overall goal is to develop novel magnetic nanoparticles with high magnetic moments that simultaneously optimize multiple functionalities i.e. effective drug targeting and increased detection sensitivity via magnetic imaging. The specific objectives of these studies are to fabricate magnetic nanoparticles with materials and compositions optimized to produce higher magnetic moments, formulate these nanoparticles into a water- based system that can be loaded with high doses of anticancer agents, functionalize nanoparticles with antibodies, and evaluate these multifunctional nanoparticles for tumor-specific magnetic drug targeting and early detection of tumor using magnetic resonance imaging. The proposed objectives will be achieved with a multidisciplinary collaborative research effort involving pharmaceutics and drug delivery, physics and biomaterial synthesis, and bioimaging technology. The specific aims of the proposal are: Aim 1: To fabricate superparamagnetic nanoparticle fluids and characterize their magnetic and other physical properties; Aim 2: To study biocompatibility, test different formulation parameters for drug loading and release, and determine antiproliferative effects of the drug-loaded magnetic nanoparticles in vitro; Aim 3: To study biodistribution of magnetic nanoparticles, magnetic targeting in response to an external magnetic field, and demonstrate tumor inhibition in a murine model of breast cancer; Aim 4: To determine the MRI detection threshold of magnetic nanoparticles for early detection of tumor. We anticipate that the novel magnetic nanomaterials developed in this proposal will overcome the major issues in magnetic drug targeting as well as achieve a high degree of sensitivity for early detection of tumor. The materials developed also can be used in other disease conditions for therapeutic and diagnostic purposes. These multifunctional magnetic nanoparticles will serve as platforms for these and other biomedical applications.

用于生物医学用途的下一代纳米粒子将使用单一纳米粒子来提供多种功能 制剂：例如，允许靶向药物输送和磁成像的磁性纳米粒子。 磁靶向未能实现其承诺的主要原因之一是磁矩 纳米颗粒随着尺寸的增加而减小。由于作用在粒子上的磁力等于磁力的乘积 外部施加磁场梯度和粒子磁矩，开发纳米粒子 显着更大的力矩至关重要。我们的总体目标是开发新型磁性纳米颗粒 高磁矩可同时优化多种功能，即有效的药物靶向 并通过磁成像提高检测灵敏度。 这些研究的具体目标是用材料和材料制造磁性纳米粒子 优化组合物以产生更高的磁矩，将这些纳米颗粒配制到水- 基于可装载高剂量抗癌剂的系统，使纳米颗粒功能化 抗体，并评估这些多功能纳米粒子用于肿瘤特异性磁性药物靶向 以及使用磁共振成像早期检测肿瘤。拟议的目标将会实现 通过多学科合作研究，涉及药剂学和药物输送、物理学 以及生物材料合成和生物成像技术。该提案的具体目标是： 目标 1： 制造超顺磁性纳米粒子流体并表征其磁性和其他 物理特性；目标 2：研究生物相容性，测试不同的配方参数 药物负载和释放，并确定载药磁性材料的抗增殖作用 体外纳米颗粒；目标 3：研究磁性纳米颗粒的生物分布、磁性 响应外部磁场进行靶向，并在小鼠中证明肿瘤抑制作用 乳腺癌模型；目标 4：确定磁性的 MRI 检测阈值 纳米粒子用于肿瘤的早期检测。 我们预计本提案中开发的新型磁性纳米材料将克服 磁性药物靶向的主要问题以及实现早期检测的高度灵敏度 的肿瘤。所开发的材料还可用于其他疾病的治疗和治疗 诊断目的。这些多功能磁性纳米粒子将作为这些和 其他生物医学应用。