IMAGING CORE

成像核心

• 批准号: 7624803
• 负责人: Michael A Weiner
• 金额: $ 12.43万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7624803
• 关键词: 3-Dimensional; Affect; Age; Alzheimer' s Disease; American; Anisotropy; Arts; Blood flow; Brain; Brain Mapping; Brain region; Cerebrospinal Fluid; Characteristics; Clinical; Data; Data Analyses; Databases; Dementia; Diagnosis; Diffusion; Disease; Early Diagnosis; Elderly; Exhibits; Fiber; Frontotemporal Dementia; Frontotemporal Lobar Degenerations; Functional Magnetic Resonance Imaging; Future; Gender; Goals; Heterogeneity; Hippocampus (Brain); Image; Impaired cognition; Incidence; Instruction; Investigation; Lead; Lesion; Lewy Body Disease; MRI Scans; Magnetic Resonance; Magnetic Resonance Imaging; Measures; Medical center; Metabolic; Methods; Neurodegenerative Disorders; Patients; Pattern; Perfusion; Prevalence; Process; Recruitment Activity; Research Design; Research Personnel; Resolution; Rest; Spin Labels; Staging; Structure; System; Techniques; Thick; Tissues; Vascular Dementia; Vascular Diseases; Weight; Work; base; expectation; gray matter; image processing; interest; member; normal aging; novel strategies; white matter

Seeinstructions): The overall long term goal of this Imaging Core is to identify structural, perfusion, and metabolic changes in the brain that predict future cognitive decline and conversion to dementia. The overall approach will be to initially study healthy elders ands age/gender matched patients with well-characterized dementia associated with Alzheimer's disease and Frontotemporal dementia using a newly acquired 4 Tesla Bruker/Siemens MRI/MRS scanner, which will be optimized for investigation of neurodegenerative disease. These initial studies will provide imaging characteristics of established dementia. We will also study a group of subjects with MCl-Peterson criteria. In subsequent years we will study increasing numbers of subjects with MCI subtypes and MCl-Peterson who likely represent early stages of AD and FTD and who are expected to ultimately convert to dementia. All subjects will be recruited and evaluated by the Clinical Core. RELEVANCE (See instructions): Alzheimer's disease affects millions of Americans, and the incidence and prevalence are growing as people get older. MRI imaging provides unique information concerning the changes in the brain which occur in demented subjects, as well as in the early stages of the disease. Imaging also helps identify other processes which lead to cognitive impairment. Thus, state of the art imaging is a critical aspect of this ADRC.

see Instructions）： 该成像核心的总体长期目标是确定结构，灌注和代谢变化 预测未来认知能力下降和转变为痴呆症的大脑。总体方法将是 最初研究健康的长老和年龄/性别与特征痴呆相关的患者 使用新获得的4种特斯拉·布鲁克/西门子，患有阿尔茨海默氏病和额颞痴呆 MRI/SCANNER夫人，将优化用于研究神经退行性疾病。这些最初 研究将提供既定痴呆症的成像特征。我们还将研究一组主题 带有MCL-Peterson标准。在随后的几年中，我们将研究越来越多的MCI受试者 亚型和MCL-Peterson可能代表AD和FTD的早期阶段，并且有望 最终转化为痴呆症。所有受试者将由临床核心招募和评估。 相关性（请参阅说明）： 阿尔茨海默氏病影响数百万美国人，随着人们的发病率和流行率正在增长 变老。 MRI成像提供了有关大脑变化发生的独特信息 痴呆的受试者以及疾病的早期阶段。成像还有助于识别其他过程 导致认知障碍。因此，最新成像的状态是该ADRC的关键方面。