DIET INDUCED OBESITY IN PAPIO: PALATABLE HIGH-FAT HIGH-FRUCTOSE DIET

狒狒饮食引起的肥胖：可口的高脂肪高果糖饮食

• 批准号: 7957921
• 负责人: RAUL A BASTARRACHEA
• 金额: $ 1.05万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-06 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7957921
• 关键词: Adult; Animals; Atherogenic Diet; Blood specimen; Body Weight; Body fat; Carbohydrates; Cholesterol; Coconut Oil; Comorbidity; Computer Retrieval of Information on Scientific Projects Database; Coronary heart disease; Development; Diet; Egg Yolk; Fat-Restricted Diet; Fatty acid glycerol esters; Food; Fructose; Funding; Glucose; Grant; Housing; Individual; Institution; Lipids; Measurement; Measures; Modeling; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Papio; Pilot Projects; Powder dose form; Predisposition; Primates; Research; Research Personnel; Resources; Risk Factors; Site; Societies; Source; United States National Institutes of Health; Vitamins; Water; Weight Gain; Work; drinking; fast food; feeding; glucose metabolism; lard; nonhuman primate; sugar

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aim of this pilot project is to establish a non-human primate model of diet induced obesity (DIO). We intend to assess the extent of accelerated development of body fat accumulation in lean baboons maintained for an extended period on a highly palatable obesogenic diet (high cholesterol; high fat; high simple carbohydrates). It has now been clearly demonstrated that obesity represents a major (and preventable) risk factor for the development of Coronary Heart Disease (CHD) and Type 2 Diabetes (T2D), primarily through its pathological effects on lipid and glucose metabolism. Our own work over the past decade here at SFBR has clearly shown that some baboons are susceptible to the development of spontaneous obesity even while being maintained on a standard chow diet (low fat; low simple carbohydrates). Given this apparent susceptibility of baboons to weight gain, we hypothesize that we can accelerate the development of obesity and its associated comorbidities (CHD and T2D) by dietary manipulation. Specifically by increasing both the fat and simple carbohydrate content of the diet to make it more representative of the diets increasingly consumed by most individuals in westernized societies we can predictably induce obesity in baboons. This study will use approximately 20 animals that will be challenged with a palatable high fat-high calorie dense diet (fed ad libitum). Half of them will also be given access to a sugar-enriched drink (using high fructose corn syrup) every day for six months. The final 10 animals (30 total) will serve as controls having been maintained on regular water and the standard chow diet offered ad libitum. The challenge will be conducted over a six month period. Anthropometric measurements will be recorded and blood samples will be drawn at baseline and every two months through the course of the study. Body fat composition will also be measured every two months. In summary, we are proposing to feed 20 animals with an "obesogenic-highly palatable-atherogenic" diet which will mimic the dietary composition of a typical fast food meal (e.g., a hamburger, large fries and large soda) but which can be fed under the normal housing conditions for our colony. The ingredients to prepare the palatable pellets are: Lard, High Fructose Corn Syrup, Crisco, Hydrog. coconut oil, Cholesterol in powder, Salt, Vitamin mixture, and Egg yolk and these pellets will be produced on site using the diet kitchen. The pellets will be baked to add palatability to the food source. Therefore the specific aim of the current pilot study will be to formulate a highly palatable obesogenic diet and maintain a group of adult baboons on this diet for six months to evaluate its effects on body weight as well as lipid and glucose status.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该试点项目的目的是建立饮食诱发肥胖症（DIO）的非人类灵长类动物模型。我们打算评估在高度可口的肥胖饮食（高胆固醇；高脂肪;高脂肪碳水化合物）上长时间维持体内脂肪积累的加速发展程度。现在已经清楚地证明，肥胖代表了冠状动脉疾病（CHD）和2型糖尿病（T2D）发展的主要（且可预防的）风险因素，主要是通过其对脂质和葡萄糖代谢的病理影响。 SFBR过去十年来，我们自己的工作清楚地表明，即使在标准的Chow饮食（低脂；低简单的碳水化合物）时，有些狒狒也容易受到自发肥胖的发展。 鉴于狒狒对体重增加的这种明显敏感性，我们假设我们可以通过饮食操纵来加速肥胖及其相关的合并症（CHD和T2D）的发展。特别是通过增加饮食中脂肪和简单的碳水化合物含量，使其更能代表西方社会中大多数人越来越多地消耗的饮食，我们可以预见，我们可以预测地诱导狒狒的肥胖症。这项研究将使用大约20只动物，这些动物将受到可口的高脂肪高热量饮食（喂养）的挑战。六个月的时间，他们中的一半也将每天获得富含糖的饮料（使用高果糖玉米糖浆）。最后的10只动物（总共30只动物）将作为对照在常规水上维持的对照，并随意提供标准的饮食。挑战将在六个月内进行。 将记录人体测量值，并在研究过程中每两个月和每两个月绘制血液样本。体内脂肪成分也将每两个月测量一次。总而言之，我们提议用“肥胖的可口元素源性”饮食喂食20只动物，这些饮食将模仿典型的快餐粉的饮食组成（例如，汉堡包，大型薯条和大苏打水），但可以在我们群体的正常住房条件下喂食。准备可口的颗粒的成分是：猪油，高果糖玉米糖浆，CRISCO，氢。椰子油，粉末，盐，维生素混合物和蛋黄的胆固醇以及这些颗粒将在现场使用减肥厨房生产。颗粒将被烘烤，以增加食物来源的可口性。因此，当前的试点研究的具体目的是制定高度可口的肥胖饮食，并在这种饮食上维持一组成年狒狒，以评估其对体重以及脂质和葡萄糖状态的影响。